FR2404633A1 - Cyanocarboxamidines et quinazolines et leur procede de fabrication - Google Patents

Cyanocarboxamidines et quinazolines et leur procede de fabrication

Info

Publication number
FR2404633A1
FR2404633A1 FR7827628A FR7827628A FR2404633A1 FR 2404633 A1 FR2404633 A1 FR 2404633A1 FR 7827628 A FR7827628 A FR 7827628A FR 7827628 A FR7827628 A FR 7827628A FR 2404633 A1 FR2404633 A1 FR 2404633A1
Authority
FR
France
Prior art keywords
cyanocarboxamidines
quinazolines
manufacturing process
cyanocarboxamidine
halohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7827628A
Other languages
English (en)
Other versions
FR2404633B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2404633A1 publication Critical patent/FR2404633A1/fr
Application granted granted Critical
Publication of FR2404633B1 publication Critical patent/FR2404633B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/21—Radicals derived from sulfur analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)

Abstract

L'invention concerne des cyanocarboxamidines et des quinazolines et leur procédé de fabrication. Les cyanocarboxamidines de l'invention sont obtenues en traitant les urées ou thiourées correspondantes avec un agent d'alkylation pour obtenir l'intermédiaire halohydrate correspondant, à faire réagir ce dernier avec de la cyanamide et les quinazolines de l'invention sont obtenues en cyclisant une cyanocarboxamidine ainsi obtenue. Les composés de l'invention sont utiles comme intermédiaires dans d'autres synthèses chimiques
FR7827628A 1977-09-30 1978-09-27 Cyanocarboxamidines et quinazolines et leur procede de fabrication Granted FR2404633A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/838,417 US4138561A (en) 1977-09-30 1977-09-30 Cyanocarboxamidines and quinazoline process

Publications (2)

Publication Number Publication Date
FR2404633A1 true FR2404633A1 (fr) 1979-04-27
FR2404633B1 FR2404633B1 (fr) 1983-05-13

Family

ID=25277044

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7827628A Granted FR2404633A1 (fr) 1977-09-30 1978-09-27 Cyanocarboxamidines et quinazolines et leur procede de fabrication

Country Status (13)

Country Link
US (1) US4138561A (fr)
JP (1) JPS5459292A (fr)
BE (1) BE870763A (fr)
CA (1) CA1121816A (fr)
CH (1) CH641172A5 (fr)
DK (1) DK429378A (fr)
FR (1) FR2404633A1 (fr)
GB (1) GB2036001B (fr)
IE (1) IE47569B1 (fr)
IT (1) IT1107496B (fr)
NL (1) NL7809799A (fr)
SE (1) SE7904690L (fr)
WO (1) WO1979000166A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381046A1 (fr) * 1977-02-22 1978-09-15 Bristol Myers Co Quinazoline et medicaments en contenant

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI57751C (fi) * 1977-10-25 1980-10-10 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner med blodtryckssaenkande verkan
EP0022481A1 (fr) * 1979-06-21 1981-01-21 Mitsubishi Yuka Pharmaceutical Co., Ltd. Dérivés de la 5,6-alcoylènepyrimidine, procédés pour leur préparation et préparations pharmaceutiques
DE3014353A1 (de) * 1980-04-15 1982-01-21 Bayer Ag, 5090 Leverkusen Trisubstituierte cyanguanidine, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
JPS5791987A (en) * 1980-11-26 1982-06-08 Sankyo Co Ltd Aminoquinazoline derivative and its preparation
US4367335A (en) * 1981-08-03 1983-01-04 Mead Johnson & Company Thiazolidinylalkylene piperazine derivatives
DE3336409A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Chinazolinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3375395D1 (en) * 1983-11-22 1988-02-25 Heumann Ludwig & Co Gmbh Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt
US4713382A (en) * 1985-05-30 1987-12-15 Syntex (U.S.A.) Inc. N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents
AT384218B (de) * 1985-12-04 1987-10-12 Gerot Pharmazeutika Verfahren zur herstellung von neuen chinazolin-derivaten
YU70890A (en) * 1989-04-21 1992-05-28 Egyt Gyogyszervegyeszeti Gyar Process for obtaining quinazoline derivatives
CA2077252C (fr) * 1992-08-31 2001-04-10 Khashayar Karimian Methodes de fabrication d'urees et de guanidines et composes intermediaires servant a ces syntheses
US5776962A (en) * 1994-08-03 1998-07-07 Cell Pathways, Inc. Lactone compounds for treating patient with precancerous lesions
US5696159A (en) * 1994-08-03 1997-12-09 Cell Pathways, Inc. Lactone compounds for treating patients with precancerous lesions
US6262059B1 (en) 1995-06-07 2001-07-17 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with quinazoline derivatives
US5874440A (en) * 1995-06-07 1999-02-23 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives
US6200980B1 (en) 1995-06-07 2001-03-13 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl purinone derivatives
US6060477A (en) * 1995-06-07 2000-05-09 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
US6046216A (en) * 1995-06-07 2000-04-04 Cell Pathways, Inc. Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
US6046206A (en) * 1995-06-07 2000-04-04 Cell Pathways, Inc. Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
US6232312B1 (en) 1995-06-07 2001-05-15 Cell Pathways, Inc. Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides
CA2238283C (fr) * 1997-05-30 2002-08-20 Cell Pathways, Inc. Methode d'identification de composes visant a inhiber les lesions neoplasiques, compositions pharmaceutiques a prtir de ces composes et compositions pour traiter les lesions neoplasiques
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US5852035A (en) * 1997-12-12 1998-12-22 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines
US6046199A (en) * 1998-01-14 2000-04-04 Cell Pathways, Inc. Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
US5942520A (en) * 1998-01-27 1999-08-24 Cell Pathways, Inc. Method for inhibiting neoplastic cells by exposure to substituted N-cycloalkylmethyl-1-H-pyrazolo (3,4-B) quinolone-4 amines
US6313294B1 (en) 1998-02-04 2001-11-06 Development Center For Biotechnology Process for preparing amides
US5990117A (en) * 1998-04-15 1999-11-23 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to quinazoline derivatives
US6180629B1 (en) 1998-08-14 2001-01-30 Cell Pathways, Inc. [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
US6268372B1 (en) 1998-09-11 2001-07-31 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
US6124303A (en) * 1998-09-11 2000-09-26 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
US6200771B1 (en) 1998-10-15 2001-03-13 Cell Pathways, Inc. Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
US6130053A (en) * 1999-08-03 2000-10-10 Cell Pathways, Inc. Method for selecting compounds for inhibition of neoplastic lesions
US6133271A (en) * 1998-11-19 2000-10-17 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
US6187779B1 (en) 1998-11-20 2001-02-13 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6486155B1 (en) 1998-11-24 2002-11-26 Cell Pathways Inc Method of inhibiting neoplastic cells with isoquinoline derivatives
US6077842A (en) * 1998-11-24 2000-06-20 Cell Pathways, Inc. Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) * 1999-02-19 2000-02-01 Cell Pathways, Inc. Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
US6555547B1 (en) 2000-02-28 2003-04-29 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
US6569638B1 (en) 2000-03-03 2003-05-27 Cell Pathways, Inc Method for screening compounds for the treatment of neoplasia
US20070086958A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Formation of medically useful gels comprising microporous particles and methods of use
US20070087061A1 (en) * 2005-10-14 2007-04-19 Medafor, Incorporated Method and composition for creating and/or activating a platelet-rich gel by contact with a porous particulate material, for use in wound care, tissue adhesion, or as a matrix for delivery of therapeutic components

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935213A (en) * 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/70 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381046A1 (fr) * 1977-02-22 1978-09-15 Bristol Myers Co Quinazoline et medicaments en contenant

Also Published As

Publication number Publication date
IE47569B1 (en) 1984-05-02
JPS5459292A (fr) 1979-05-12
IT1107496B (it) 1985-11-25
CA1121816A (fr) 1982-04-13
US4138561A (en) 1979-02-06
NL7809799A (nl) 1979-04-03
IE781958L (en) 1979-03-30
IT7851318A0 (it) 1978-09-29
DK429378A (da) 1979-03-31
CH641172A5 (de) 1984-02-15
WO1979000166A1 (fr) 1979-04-05
GB2036001A (en) 1980-06-25
SE7904690L (sv) 1979-05-29
FR2404633B1 (fr) 1983-05-13
GB2036001B (en) 1982-07-07
BE870763A (fr) 1979-03-26

Similar Documents

Publication Publication Date Title
FR2404633A1 (fr) Cyanocarboxamidines et quinazolines et leur procede de fabrication
FR2361902A1 (fr) Derives de la glucosamine et leur procede de fabrication
BR8200553A (pt) Processo de obtencao de compostos com grupos isocianuricos monomeros ou polimeros por ciclotrimerizacao catalitica de isocianatos;processo de obtencao de poliisocianato-poliisocianurato;por ciclotrimerizacao de di isocianato alifatico ou cicloalifatico e compostos contendo grupos isocianuricos
FR2393818A1 (fr) Procede de preparation de polyimides cycliques lineaires
FI882418A (fi) Menetelmä valmistaa terapeuttisesti aktiivisia syklisiä amiinijohdannaisia
BE890862A (fr) Procede de recuit continu pour la producton de tole d'acier doux laminee a froid
FR2426051A1 (fr) Nouvelles 3-aryloxy-substitue-aminopyridines et procedes pour leur production
FR2386532A1 (fr) Nouvelles (thio)urees substituees, leur procede de preparation et leur application comme insecticides.
DE68923103T2 (de) Verfahren zur Herstellung von 2-Amino-4,6-dichloro-Pyrimidin.
BE852583A (fr) Procede de fabrication directe d'acier brut
IT1079052B (it) Procedimento per la produzione di acido 8 ammino 1 nafto 3,6 disolfonico
FR2388844A1 (fr) Procede d'obtention en discontinu de polymeres derives de para-phenylenediamine
ES8106126A1 (es) Procedimiento para obtencion de intermediarios para la pro- duccion de penicilinas
FR2463781B1 (fr) Procede pour la production de polypropylene ayant une aptitude a l'etirage amelioree
FR2358387A1 (fr) Nouveaux oxime-carbamates de cetones fluorees, leur procede de preparation et leur application comme insecticides, acaricides et nematicides
FR2406647A1 (fr) Procede de preparation de liants deposables a la cathode
FR2374314A1 (fr) Procede de production d'acide cyanurique a partir d'uree et nouveau produit ainsi obtenu
BR9603728A (pt) Processo para a produção de um composto
FR2405313A1 (fr) Procede de production de files de polyamide a auto-plissement ou auto-ondulation et nouveaux produits ainsi obtenus
FR2381741A1 (fr) 1-arylamino-2,4-dinitronaphtalenes, leur procede de preparation et leur application comme pesticides
EP0248220A3 (fr) Procédé de préparation d'urées cycliques
BE894424A (fr) Procede de fabrication de tole ou de feuillard d'acier d'emboutissage lamine a froid
EP0171811A3 (fr) Production d'acétal amide bicyclique
US4245102A (en) Processes for the preparation of tetramisole
CA1135270A (fr) Procedes d'obtention de tetramisole et nouveaux intermediaires

Legal Events

Date Code Title Description
ST Notification of lapse