FR2403999A1 - Derives de fluoro-uracile et procede de leur preparation ainsi que leur application pharmaceutique - Google Patents

Derives de fluoro-uracile et procede de leur preparation ainsi que leur application pharmaceutique

Info

Publication number
FR2403999A1
FR2403999A1 FR7826922A FR7826922A FR2403999A1 FR 2403999 A1 FR2403999 A1 FR 2403999A1 FR 7826922 A FR7826922 A FR 7826922A FR 7826922 A FR7826922 A FR 7826922A FR 2403999 A1 FR2403999 A1 FR 2403999A1
Authority
FR
France
Prior art keywords
derivatives
preparation
fluoruracil
well
pharmaceutical application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826922A
Other languages
English (en)
Other versions
FR2403999B1 (fr
Inventor
Koichi Matsumura
Osamu Miyashita
Hiroshi Shimadzu
Naoto Hashimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2403999A1 publication Critical patent/FR2403999A1/fr
Application granted granted Critical
Publication of FR2403999B1 publication Critical patent/FR2403999B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention a pour objet des dérivés de fluoro-acile et un procédé de leur préparation. Les composés de l'invention répondent à la formule :
FR7826922A 1977-09-22 1978-09-20 Derives de fluoro-uracile et procede de leur preparation ainsi que leur application pharmaceutique Granted FR2403999A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11419377A JPS5446791A (en) 1977-09-22 1977-09-22 Fluorouracil derivative

Publications (2)

Publication Number Publication Date
FR2403999A1 true FR2403999A1 (fr) 1979-04-20
FR2403999B1 FR2403999B1 (fr) 1982-07-30

Family

ID=14631520

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826922A Granted FR2403999A1 (fr) 1977-09-22 1978-09-20 Derives de fluoro-uracile et procede de leur preparation ainsi que leur application pharmaceutique

Country Status (7)

Country Link
US (1) US4190656A (fr)
JP (1) JPS5446791A (fr)
CH (1) CH633537A5 (fr)
DE (1) DE2841379A1 (fr)
FR (1) FR2403999A1 (fr)
GB (1) GB2004545B (fr)
IT (1) IT1099129B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913780A (ja) * 1982-07-13 1984-01-24 Takeda Chem Ind Ltd フルオロウラシル誘導体および抗腫瘍剤
JP2640664B2 (ja) * 1988-03-31 1997-08-13 クミアイ化学工業株式会社 ピリミジン誘導体及び除草剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3277092A (en) 1963-05-02 1966-10-04 Hoffmann La Roche 5, 6-substituted dihydro-5-fluoropyrimidines
US3360523A (en) * 1964-06-17 1967-12-26 Du Pont 3, 5, 6-substituted hydrouracils
US3406023A (en) * 1966-10-31 1968-10-15 Du Pont Herbicidal method
US3954758A (en) * 1970-05-27 1976-05-04 Pcr, Inc. Process for fluorinating uracil and derivatives thereof
CH553195A (de) * 1971-03-19 1974-08-30 Sandoz Ag Verfahren zur herstellung neuer 2,6-dichlor-benzaldoximo-(s-triazinyl-(6))-aether.
US3987045A (en) * 1971-05-03 1976-10-19 Basf Aktiengesellschaft Disperse dyes based on isoindolene derivatives
US3954759A (en) * 1972-07-13 1976-05-04 Pcr, Inc. Process for preparation of 6-substituted 5-fluorouracil derivatives
DE2401619C2 (de) * 1974-01-14 1986-04-03 Kailash Kumar Prof. Dr. 2359 Lentföhrden Gauri Fungistatisch wirksame Uracilderivate und Verfahren zu ihrer Herstellung
DE2602175B2 (de) * 1975-01-22 1978-05-03 Asahi Kasei Kogyo K.K., Osaka (Japan) 1 -Alkanoyl-5-fluor-uracilderivate und ihre Verwendung
US4071519A (en) * 1975-11-05 1978-01-31 Mitsui Toatsu Chemicals, Incorporated 1-Carbamoyl-5-fluorouracil derivatives
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
GB2004545B (en) 1982-04-07
FR2403999B1 (fr) 1982-07-30
JPS6145619B2 (fr) 1986-10-08
US4190656A (en) 1980-02-26
CH633537A5 (fr) 1982-12-15
IT1099129B (it) 1985-09-18
GB2004545A (en) 1979-04-04
JPS5446791A (en) 1979-04-12
DE2841379A1 (de) 1979-03-29
IT7827934A0 (it) 1978-09-21

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Legal Events

Date Code Title Description
ST Notification of lapse