FR2399999A1 - Prostane derivs. - useful as contraceptives or for control of the oestrus cycle in animals - Google Patents
Prostane derivs. - useful as contraceptives or for control of the oestrus cycle in animalsInfo
- Publication number
- FR2399999A1 FR2399999A1 FR7822821A FR7822821A FR2399999A1 FR 2399999 A1 FR2399999 A1 FR 2399999A1 FR 7822821 A FR7822821 A FR 7822821A FR 7822821 A FR7822821 A FR 7822821A FR 2399999 A1 FR2399999 A1 FR 2399999A1
- Authority
- FR
- France
- Prior art keywords
- formula
- prostane
- derivs
- contraceptives
- animals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241001465754 Metazoa Species 0.000 title abstract 2
- 229940124558 contraceptive agent Drugs 0.000 title abstract 2
- 239000003433 contraceptive agent Substances 0.000 title abstract 2
- UKVVPDHLUHAJNZ-PMACEKPBSA-N prostane Chemical compound CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC UKVVPDHLUHAJNZ-PMACEKPBSA-N 0.000 title abstract 2
- 230000012173 estrus Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000009079 Bronchial Spasm Diseases 0.000 abstract 1
- 208000014181 Bronchial disease Diseases 0.000 abstract 1
- 206010006482 Bronchospasm Diseases 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010000210 abortion Diseases 0.000 abstract 1
- 231100000176 abortion Toxicity 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000005529 alkyleneoxy group Chemical group 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000004211 gastric acid Anatomy 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000003529 luteolytic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prostane derivs. of formula (I) are new. In the formula, the gp. (II) is of formula (III) to (VI); R1 is 1-10C opt. branched alkyl, alkoxyalkyl or haloalkyl, 1-6C omega-carboxyalkyl, phenyl or naphthyl opt. substd. by one or more halo, nitro phenyl, 1-5C alkyl, alkoxy or haloalkyl. R2-4 are each H or 1-5C alkyl; X is ethylene or trans-vinylene; Y is 1-6C alkyleneoxy where the O atom is bonded to R5, 1-6C alkylene or a direct bond; R5 is phenyl or naphthyl opt. substd. as above; n is 1-4; and m is 0 or 1. (I) possess high luteolytic activity and are therefore useful as contraceptives or for control of the oestrous cycle in animals. Some (I) also possess high activity in preventing blood platelet aggregation. (I) may be used to induce labour or early abortion, or as hypotensives for the relief of broncho-spasm or the inhibition of gastric acid production.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3392077 | 1977-08-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2399999A1 true FR2399999A1 (en) | 1979-03-09 |
| FR2399999B1 FR2399999B1 (en) | 1980-10-31 |
Family
ID=10359131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7822821A Granted FR2399999A1 (en) | 1977-08-12 | 1978-08-02 | Prostane derivs. - useful as contraceptives or for control of the oestrus cycle in animals |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS5432458A (en) |
| DE (1) | DE2835538A1 (en) |
| FR (1) | FR2399999A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62223262A (en) * | 1986-03-26 | 1987-10-01 | Mitsubishi Gas Chem Co Inc | Polyamide resin composition for molding material |
| JP5507181B2 (en) | 2009-09-29 | 2014-05-28 | 富士フイルム株式会社 | Radiographic imaging apparatus and method of operating radiographic imaging apparatus |
| KR101845405B1 (en) | 2009-11-27 | 2018-04-05 | 미쯔비시 가스 케미칼 컴파니, 인코포레이티드 | Copolymerized polyamide resin, method for producing same, resin composition, and molded article formed from the copolymerized polyamide resin or the resin composition |
| JP4779148B1 (en) * | 2010-11-26 | 2011-09-28 | 千治 佐藤 | Ratchet type cycle machine |
| WO2013038846A1 (en) | 2011-09-12 | 2013-03-21 | 三菱瓦斯化学株式会社 | Thin-walled molding |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2322587A1 (en) * | 1975-08-22 | 1977-04-01 | Ici Ltd | PROSTANE DERIVATIVES |
-
1978
- 1978-08-02 FR FR7822821A patent/FR2399999A1/en active Granted
- 1978-08-11 JP JP9811478A patent/JPS5432458A/en active Pending
- 1978-08-14 DE DE19782835538 patent/DE2835538A1/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2322587A1 (en) * | 1975-08-22 | 1977-04-01 | Ici Ltd | PROSTANE DERIVATIVES |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2835538A1 (en) | 1979-02-22 |
| FR2399999B1 (en) | 1980-10-31 |
| JPS5432458A (en) | 1979-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |