FR2396078A1 - Procede de production de substances inhibant la b lactamase et plus specialement de la mc 696 sy-2a - Google Patents
Procede de production de substances inhibant la b lactamase et plus specialement de la mc 696 sy-2aInfo
- Publication number
- FR2396078A1 FR2396078A1 FR7820095A FR7820095A FR2396078A1 FR 2396078 A1 FR2396078 A1 FR 2396078A1 FR 7820095 A FR7820095 A FR 7820095A FR 7820095 A FR7820095 A FR 7820095A FR 2396078 A1 FR2396078 A1 FR 2396078A1
- Authority
- FR
- France
- Prior art keywords
- soln
- salt
- contg
- beta
- lactamase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ce procédé de production consiste à cultiver une souche MC 696 SY 2 Streptomyces fulvoridis (identifié comme FERM-P 1504 on ATCC 21954), afin de produire et d'accumuler la substance MC 696 - SY 2A dans le milieu de culture puis à récupérer cette substance du bouillon de culture contenant la substance MC 696 - SY 2A, alors que cette substance est maintenue sous forme de sel de la substance MC 696 - SY 2A, après avoir converti, dans une phase appropriée antérieure du processus de récupération et de purification ladite substance en son sel.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7655777A JPS5414594A (en) | 1977-06-29 | 1977-06-29 | Preparation of beta-lactamase inhibiting substance |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2396078A1 true FR2396078A1 (fr) | 1979-01-26 |
FR2396078B1 FR2396078B1 (fr) | 1980-11-14 |
Family
ID=13608545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7820095A Granted FR2396078A1 (fr) | 1977-06-29 | 1978-06-27 | Procede de production de substances inhibant la b lactamase et plus specialement de la mc 696 sy-2a |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5414594A (fr) |
ES (1) | ES471250A1 (fr) |
FR (1) | FR2396078A1 (fr) |
IT (1) | IT1103066B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0008885A1 (fr) * | 1978-09-09 | 1980-03-19 | Beecham Group Plc | Composés de bêta-lactame, leur préparation et application |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4988570A (en) * | 1985-09-11 | 1991-01-29 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Process for forming a film |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2106582A1 (fr) * | 1970-09-17 | 1972-05-05 | Beecham Group Ltd | |
FR2265398A1 (fr) * | 1974-03-28 | 1975-10-24 | Beecham Group Ltd |
-
1977
- 1977-06-29 JP JP7655777A patent/JPS5414594A/ja active Pending
-
1978
- 1978-06-27 FR FR7820095A patent/FR2396078A1/fr active Granted
- 1978-06-28 IT IT789512A patent/IT1103066B/it active
- 1978-06-29 ES ES471250A patent/ES471250A1/es not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2106582A1 (fr) * | 1970-09-17 | 1972-05-05 | Beecham Group Ltd | |
FR2265398A1 (fr) * | 1974-03-28 | 1975-10-24 | Beecham Group Ltd |
Non-Patent Citations (1)
Title |
---|
NV2321/77 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0008885A1 (fr) * | 1978-09-09 | 1980-03-19 | Beecham Group Plc | Composés de bêta-lactame, leur préparation et application |
Also Published As
Publication number | Publication date |
---|---|
FR2396078B1 (fr) | 1980-11-14 |
ES471250A1 (es) | 1979-10-01 |
JPS5414594A (en) | 1979-02-02 |
IT1103066B (it) | 1985-10-14 |
IT7809512A0 (it) | 1978-06-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |