FR2387991A1 - Complexes peptidiques d'organismes contenant des acides desoxyribonucleiques et leur application pharmaceutique - Google Patents

Complexes peptidiques d'organismes contenant des acides desoxyribonucleiques et leur application pharmaceutique

Info

Publication number
FR2387991A1
FR2387991A1 FR7811484A FR7811484A FR2387991A1 FR 2387991 A1 FR2387991 A1 FR 2387991A1 FR 7811484 A FR7811484 A FR 7811484A FR 7811484 A FR7811484 A FR 7811484A FR 2387991 A1 FR2387991 A1 FR 2387991A1
Authority
FR
France
Prior art keywords
acid
peptide complexes
aspargic
organisms containing
content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811484A
Other languages
English (en)
Other versions
FR2387991B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
R & Z Vermoegensverw GmbH
Original Assignee
R & Z Vermoegensverw GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772717476 external-priority patent/DE2717476A1/de
Priority claimed from DE19772717475 external-priority patent/DE2717475A1/de
Priority claimed from DE19772749554 external-priority patent/DE2749554A1/de
Application filed by R & Z Vermoegensverw GmbH filed Critical R & Z Vermoegensverw GmbH
Publication of FR2387991A1 publication Critical patent/FR2387991A1/fr
Application granted granted Critical
Publication of FR2387991B1 publication Critical patent/FR2387991B1/fr
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6025—Nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/821—Separation of nucleic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/822—Protozoa
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/823—Lower fungi, e.g. mold
    • Y10S530/824—Yeasts
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention a pour objet des complexes peptidiques préparés à partir d'organismes contenant de l'acide désoxyribonucléique. Elle est caractérisée en ce que ces complexes peptidiques possèdent les propriétés suivantes : a. Un poids moléculaire inférieur à 5 000; b. Une liaison avec acide ribonucléique d'un poids moléculaire moyen, qui donne une bande typique par électrophorèse de gel et par électrophorèse sur feuille d'acétate; c. Un comportement de préférence intracellulaire; d. Une teneur en calcium; e. Une réaction de précipitation avec des ions Terbium III; f. Une très bonne solubilité dans l'eau; g. Une teneur moyenne en acide aspargique et glutaminique d'environ 30 % moles (rapportée à la teneur totale en aminoacides); h. Un rapport molaire (acide aspargique + acide glutamique)/(Lysine + Arginine) supérieure à 1; i. Une composition spécifique en aminoacides; k. Un effet antigène; et l. Un effet d'augmentation de résistance. Elle concerne des médicaments contenant lesdits complexes peptidiques.
FR7811484A 1977-04-20 1978-04-19 Complexes peptidiques d'organismes contenant des acides desoxyribonucleiques et leur application pharmaceutique Granted FR2387991A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19772717476 DE2717476A1 (de) 1977-04-20 1977-04-20 Peptidkomplex mit fuer mycobacterium tuberculosis und mycobacterium leprae spezifischen antigendeterminanten, zur diagnostischen, prophylaktischen und therapeutischen anwendung
DE19772717475 DE2717475A1 (de) 1977-04-20 1977-04-20 Peptidkomplex mit resistenzsteigernder wirkung gegen eine infektion mit bordetella pertussis keimen, seine verwendung zu impfstoffzubereitungen und diagnostischen zwecken
DE19772749554 DE2749554A1 (de) 1977-11-05 1977-11-05 Peptidkomplexe aus desoxyribonucleinsaeurehaltigen organismen mit jeweils spezifischen antigendeterminanten fuer den organismus, aus dem sie gewonnen werden, zur diagnostischen, prophylaktischen und therapeutischen anwendung

Publications (2)

Publication Number Publication Date
FR2387991A1 true FR2387991A1 (fr) 1978-11-17
FR2387991B1 FR2387991B1 (fr) 1982-07-23

Family

ID=27187175

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811484A Granted FR2387991A1 (fr) 1977-04-20 1978-04-19 Complexes peptidiques d'organismes contenant des acides desoxyribonucleiques et leur application pharmaceutique

Country Status (17)

Country Link
US (1) US4228068A (fr)
JP (1) JPS5417108A (fr)
AT (1) AT374928B (fr)
CA (1) CA1128860A (fr)
CH (1) CH639667A5 (fr)
DK (1) DK168078A (fr)
EG (1) EG14174A (fr)
ES (1) ES468918A1 (fr)
FI (1) FI781194A (fr)
FR (1) FR2387991A1 (fr)
GB (1) GB1603189A (fr)
IE (1) IE46618B1 (fr)
IT (1) IT1112622B (fr)
NL (1) NL7803973A (fr)
NO (1) NO151153C (fr)
PT (1) PT67916B (fr)
SE (1) SE7804098L (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8402861L (sv) * 1984-05-28 1985-11-29 Stefan Svenson Rening av biologiskt material
US5013720A (en) * 1986-05-06 1991-05-07 Abbott Laboratories SAP-6-Val proteins and methods
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
US5371112A (en) * 1992-01-23 1994-12-06 The Sherwin-Williams Company Aqueous coating compositions from polyethylene terephthalate
MD3942C2 (ro) * 2009-01-22 2010-02-28 Институт Химии Академии Наук Молдовы Complecşi ai fierului şi cobaltului cu acidul furan-2-carboxilic cu proprietăţi antituberculoase
CN103351352B (zh) * 2013-07-15 2015-10-21 南通市华峰化工有限责任公司 一种5-苯基四氮唑新合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2741653A (en) * 1954-03-19 1956-04-10 Univ California Method of isolating nucleoproteins
US3862109A (en) * 1968-10-12 1975-01-21 Hitachi Ltd Method for obtaining a protein isolate from hydrocarbon assimilating microbial cells
US4007088A (en) * 1972-06-14 1977-02-08 Ceskoslovenska Akademie Ved Process of manufacturing native microbial protein with a low content of nucleic acids
SU473720A1 (ru) * 1972-09-15 1975-06-14 Институт Биологически Активных Веществ Дальневосточного Научного Центра Способ совместного получени протамин-сульфата и дезоксирибонуклеиновой кислоты
US3887431A (en) * 1972-11-29 1975-06-03 Anheuser Busch Yeast protein isolate with reduced nucleic acid content and process of making same
SE7401668L (fr) * 1974-02-07 1975-08-08 Scp Exploatering Ab
US3991215A (en) * 1974-02-11 1976-11-09 Anheuser-Busch, Incorporated Manufacture of yeast protein isolate having a reduced nucleic acid content by a thermal process

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1969 *
CA1972 *

Also Published As

Publication number Publication date
AT374928B (de) 1984-06-12
DK168078A (da) 1978-10-21
NO151153C (no) 1985-02-20
EG14174A (en) 1983-03-31
NO151153B (no) 1984-11-12
JPS5417108A (en) 1979-02-08
FR2387991B1 (fr) 1982-07-23
IT7822501A0 (it) 1978-04-20
IE780767L (en) 1978-10-20
ES468918A1 (es) 1979-08-16
ATA260878A (de) 1983-10-15
NO781360L (no) 1978-10-23
IT1112622B (it) 1986-01-20
SE7804098L (sv) 1978-10-21
CA1128860A (fr) 1982-08-03
PT67916B (de) 1979-11-14
US4228068A (en) 1980-10-14
IE46618B1 (en) 1983-08-10
CH639667A5 (de) 1983-11-30
FI781194A (fi) 1978-10-21
NL7803973A (nl) 1978-10-24
GB1603189A (en) 1981-11-18
PT67916A (de) 1978-05-01

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