FR2386529A1 - 7-aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2h-indazoles et leur utilisation comme anti-inflammatoire - Google Patents

7-aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2h-indazoles et leur utilisation comme anti-inflammatoire

Info

Publication number
FR2386529A1
FR2386529A1 FR7810141A FR7810141A FR2386529A1 FR 2386529 A1 FR2386529 A1 FR 2386529A1 FR 7810141 A FR7810141 A FR 7810141A FR 7810141 A FR7810141 A FR 7810141A FR 2386529 A1 FR2386529 A1 FR 2386529A1
Authority
FR
France
Prior art keywords
indazoles
diaryl
hexahydro
aminoalkyl
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7810141A
Other languages
English (en)
Other versions
FR2386529B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2386529A1 publication Critical patent/FR2386529A1/fr
Application granted granted Critical
Publication of FR2386529B1 publication Critical patent/FR2386529B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/683—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des nouveaux composés ainsi que leurs sels pharmaceutiquement acceptables. Ces composés répondent à la formule :
FR7810141A 1977-04-07 1978-04-05 7-aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2h-indazoles et leur utilisation comme anti-inflammatoire Granted FR2386529A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/785,396 US4085280A (en) 1977-04-07 1977-04-07 7-Aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2H-indazoles

Publications (2)

Publication Number Publication Date
FR2386529A1 true FR2386529A1 (fr) 1978-11-03
FR2386529B1 FR2386529B1 (fr) 1980-08-14

Family

ID=25135386

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7810141A Granted FR2386529A1 (fr) 1977-04-07 1978-04-05 7-aminoalkyl-3,7-diaryl-3,3a,4,5,6,7-hexahydro-2h-indazoles et leur utilisation comme anti-inflammatoire

Country Status (6)

Country Link
US (1) US4085280A (fr)
JP (1) JPS53127469A (fr)
CA (1) CA1090339A (fr)
DE (1) DE2814948A1 (fr)
FR (1) FR2386529A1 (fr)
GB (1) GB1597555A (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4835025B2 (ja) * 2005-04-14 2011-12-14 トヨタ自動車株式会社 蓄電装置の製造方法
US10526323B2 (en) 2015-01-30 2020-01-07 Vanderbilt University Indazole and azaindazole substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2024099393A1 (fr) * 2022-11-09 2024-05-16 中国科学院上海药物研究所 Composé amine contenant un aryle, son procédé de préparation et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3926988A (en) * 1974-05-06 1975-12-16 Squibb & Sons Inc Substituted pyrazoles

Also Published As

Publication number Publication date
FR2386529B1 (fr) 1980-08-14
GB1597555A (en) 1981-09-09
DE2814948A1 (de) 1978-10-12
US4085280A (en) 1978-04-18
JPS53127469A (en) 1978-11-07
CA1090339A (fr) 1980-11-25

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Legal Events

Date Code Title Description
ST Notification of lapse