FR2384757A1 - Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid - Google Patents

Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid

Info

Publication number
FR2384757A1
FR2384757A1 FR7708972A FR7708972A FR2384757A1 FR 2384757 A1 FR2384757 A1 FR 2384757A1 FR 7708972 A FR7708972 A FR 7708972A FR 7708972 A FR7708972 A FR 7708972A FR 2384757 A1 FR2384757 A1 FR 2384757A1
Authority
FR
France
Prior art keywords
sulphonyl
amino
sodium ethoxide
imidazole
antifungal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7708972A
Other languages
French (fr)
Other versions
FR2384757B1 (en
Inventor
Daniel Frehel
Jean-Pierre Maffrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Priority to FR7708972A priority Critical patent/FR2384757A1/en
Publication of FR2384757A1 publication Critical patent/FR2384757A1/en
Application granted granted Critical
Publication of FR2384757B1 publication Critical patent/FR2384757B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sulphonylamin imidazoles of formula (I) and their salts are new: (where Rl is alkyl, cycloalkyl, alkenyl, alkadienyl, alkynyl, or dialkylaminoalkyl, or it is aralkyl opt. substd. by halogen, alkyl or alkoxy; R2 is H or methyl; X is H, halogen, alkyl, amino or acylamino). The cpds. are antibacterials, antifungal agents and hypoglycemics for human and veterinary use. A typical prod. is 2-cyclohexyl-5-methyl-2-p-toluene sulphonamide imidazole methane sulphonate obtd. by treating 1-cyclo-hexyl 3-(2-propynyl)-2-p-toluene sulphonyl guanidine soln. in ethanol with sodium ethoxide in ethanol, refluxing and converting the extd. prod. to the methane sulphonate.
FR7708972A 1977-03-25 1977-03-25 Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid Granted FR2384757A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7708972A FR2384757A1 (en) 1977-03-25 1977-03-25 Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7708972A FR2384757A1 (en) 1977-03-25 1977-03-25 Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid

Publications (2)

Publication Number Publication Date
FR2384757A1 true FR2384757A1 (en) 1978-10-20
FR2384757B1 FR2384757B1 (en) 1979-07-20

Family

ID=9188582

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7708972A Granted FR2384757A1 (en) 1977-03-25 1977-03-25 Antibacterial, antifungal, hypoglycaemic sulphonyl-amino imidazole(s) - prepd. by cyclising sulphonyl-amino guanidine with sodium ethoxide or formic acid

Country Status (1)

Country Link
FR (1) FR2384757A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7635774B2 (en) 2001-10-09 2009-12-22 Amgen Inc. Benzimidazole derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB521821A (en) * 1938-11-28 1940-05-31 May & Baker Ltd The preparation of new therapeutically useful heterocyclic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB521821A (en) * 1938-11-28 1940-05-31 May & Baker Ltd The preparation of new therapeutically useful heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7635774B2 (en) 2001-10-09 2009-12-22 Amgen Inc. Benzimidazole derivatives

Also Published As

Publication number Publication date
FR2384757B1 (en) 1979-07-20

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