FR2381784A1 - Proteinase de trypanosomes, son procede de preparation et son application therapeutique - Google Patents

Proteinase de trypanosomes, son procede de preparation et son application therapeutique

Info

Publication number
FR2381784A1
FR2381784A1 FR7805547A FR7805547A FR2381784A1 FR 2381784 A1 FR2381784 A1 FR 2381784A1 FR 7805547 A FR7805547 A FR 7805547A FR 7805547 A FR7805547 A FR 7805547A FR 2381784 A1 FR2381784 A1 FR 2381784A1
Authority
FR
France
Prior art keywords
proteinase
trypanosome
preparation process
therapeutic application
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7805547A
Other languages
English (en)
Other versions
FR2381784B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of FR2381784A1 publication Critical patent/FR2381784A1/fr
Application granted granted Critical
Publication of FR2381784B1 publication Critical patent/FR2381784B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/005—Trypanosoma antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention est relative à une protéinase obtenue à partir de Trypanosoma cruzi, caractérisée par : a. un poids moléculaire moyen de 200 000 + 40 000; b. un point isoélectrique à un pH de 5,3 + 0,2; c. une constante de Michaelis avec le substrat p-nitroanilide d' alpha -N-benzoyle-arginine de 1,22 x 10**-4 M +- 0,05; d. un optimum réactionnel avec le nitroanilide d' alpha -N-benzoyl-arginine comme substrat à un pH de 8,5 +- 1,5 et une température de 40 degrés C +- 10 degrés C. Cette protéinase est utilisable comme principe actif d'un médicament
FR7805547A 1977-02-26 1978-02-27 Proteinase de trypanosomes, son procede de preparation et son application therapeutique Granted FR2381784A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772708384 DE2708384A1 (de) 1977-02-26 1977-02-26 Proteinasen aus trypanosomen, verfahren zu deren herstellung sowie ihre verwendung

Publications (2)

Publication Number Publication Date
FR2381784A1 true FR2381784A1 (fr) 1978-09-22
FR2381784B1 FR2381784B1 (fr) 1980-06-20

Family

ID=6002224

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7805547A Granted FR2381784A1 (fr) 1977-02-26 1978-02-27 Proteinase de trypanosomes, son procede de preparation et son application therapeutique

Country Status (4)

Country Link
AR (1) AR227868A1 (fr)
DE (1) DE2708384A1 (fr)
FR (1) FR2381784A1 (fr)
GB (1) GB1592535A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187721A2 (fr) * 1985-01-11 1986-07-16 E.I. Du Pont De Nemours And Company Préparation de substrats peptidiques pour les protéases virus-spécifiées

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911097A (en) * 1973-08-07 1975-10-07 Research Corp Antigenic preparation suitable for diagnosis of chronic chagas disease
US3993743A (en) * 1973-08-07 1976-11-23 Research Corporation Method for diagnosis of Chagas' disease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3911097A (en) * 1973-08-07 1975-10-07 Research Corp Antigenic preparation suitable for diagnosis of chronic chagas disease
US3993743A (en) * 1973-08-07 1976-11-23 Research Corporation Method for diagnosis of Chagas' disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1978 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187721A2 (fr) * 1985-01-11 1986-07-16 E.I. Du Pont De Nemours And Company Préparation de substrats peptidiques pour les protéases virus-spécifiées
EP0187721A3 (fr) * 1985-01-11 1988-11-23 E.I. Du Pont De Nemours And Company Préparation de substrats peptidiques pour les protéases virus-spécifiées

Also Published As

Publication number Publication date
AR227868A1 (es) 1982-12-30
DE2708384A1 (de) 1978-09-07
GB1592535A (en) 1981-07-08
FR2381784B1 (fr) 1980-06-20

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Legal Events

Date Code Title Description
ST Notification of lapse