FR2381784A1 - Proteinase de trypanosomes, son procede de preparation et son application therapeutique - Google Patents
Proteinase de trypanosomes, son procede de preparation et son application therapeutiqueInfo
- Publication number
- FR2381784A1 FR2381784A1 FR7805547A FR7805547A FR2381784A1 FR 2381784 A1 FR2381784 A1 FR 2381784A1 FR 7805547 A FR7805547 A FR 7805547A FR 7805547 A FR7805547 A FR 7805547A FR 2381784 A1 FR2381784 A1 FR 2381784A1
- Authority
- FR
- France
- Prior art keywords
- proteinase
- trypanosome
- preparation process
- therapeutic application
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/005—Trypanosoma antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention est relative à une protéinase obtenue à partir de Trypanosoma cruzi, caractérisée par : a. un poids moléculaire moyen de 200 000 + 40 000; b. un point isoélectrique à un pH de 5,3 + 0,2; c. une constante de Michaelis avec le substrat p-nitroanilide d' alpha -N-benzoyle-arginine de 1,22 x 10**-4 M +- 0,05; d. un optimum réactionnel avec le nitroanilide d' alpha -N-benzoyl-arginine comme substrat à un pH de 8,5 +- 1,5 et une température de 40 degrés C +- 10 degrés C. Cette protéinase est utilisable comme principe actif d'un médicament
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772708384 DE2708384A1 (de) | 1977-02-26 | 1977-02-26 | Proteinasen aus trypanosomen, verfahren zu deren herstellung sowie ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2381784A1 true FR2381784A1 (fr) | 1978-09-22 |
FR2381784B1 FR2381784B1 (fr) | 1980-06-20 |
Family
ID=6002224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7805547A Granted FR2381784A1 (fr) | 1977-02-26 | 1978-02-27 | Proteinase de trypanosomes, son procede de preparation et son application therapeutique |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR227868A1 (fr) |
DE (1) | DE2708384A1 (fr) |
FR (1) | FR2381784A1 (fr) |
GB (1) | GB1592535A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0187721A2 (fr) * | 1985-01-11 | 1986-07-16 | E.I. Du Pont De Nemours And Company | Préparation de substrats peptidiques pour les protéases virus-spécifiées |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3911097A (en) * | 1973-08-07 | 1975-10-07 | Research Corp | Antigenic preparation suitable for diagnosis of chronic chagas disease |
US3993743A (en) * | 1973-08-07 | 1976-11-23 | Research Corporation | Method for diagnosis of Chagas' disease |
-
1977
- 1977-02-26 DE DE19772708384 patent/DE2708384A1/de not_active Withdrawn
-
1978
- 1978-02-24 AR AR271212A patent/AR227868A1/es active
- 1978-02-24 GB GB7448/78A patent/GB1592535A/en not_active Expired
- 1978-02-27 FR FR7805547A patent/FR2381784A1/fr active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3911097A (en) * | 1973-08-07 | 1975-10-07 | Research Corp | Antigenic preparation suitable for diagnosis of chronic chagas disease |
US3993743A (en) * | 1973-08-07 | 1976-11-23 | Research Corporation | Method for diagnosis of Chagas' disease |
Non-Patent Citations (1)
Title |
---|
CA1978 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0187721A2 (fr) * | 1985-01-11 | 1986-07-16 | E.I. Du Pont De Nemours And Company | Préparation de substrats peptidiques pour les protéases virus-spécifiées |
EP0187721A3 (fr) * | 1985-01-11 | 1988-11-23 | E.I. Du Pont De Nemours And Company | Préparation de substrats peptidiques pour les protéases virus-spécifiées |
Also Published As
Publication number | Publication date |
---|---|
AR227868A1 (es) | 1982-12-30 |
DE2708384A1 (de) | 1978-09-07 |
GB1592535A (en) | 1981-07-08 |
FR2381784B1 (fr) | 1980-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |