FR2378768A1 - 2,6-methano-3-benzazocines et leur utilisation comme medicaments - Google Patents
2,6-methano-3-benzazocines et leur utilisation comme medicamentsInfo
- Publication number
- FR2378768A1 FR2378768A1 FR7803369A FR7803369A FR2378768A1 FR 2378768 A1 FR2378768 A1 FR 2378768A1 FR 7803369 A FR7803369 A FR 7803369A FR 7803369 A FR7803369 A FR 7803369A FR 2378768 A1 FR2378768 A1 FR 2378768A1
- Authority
- FR
- France
- Prior art keywords
- methano
- benzazocines
- medicinal products
- alkyl
- octahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne de nouvelles 3 - R1 - 6 (eq) - R4 - 7 - R2 '' - 8 - R2 - 9 - R2 '- 10 - R2 '' - 11(ax - R3 - 11(eq) - CH2 CH2 COR5 - 2,6 - méthano - 3 - benzozacines où R5 est un groupement (alkylthio inférieur) alkyle inférieur, (alcoxy inférieur)-alkyle inférieur, alcoxy inférieur, cycloalkyle, cycloalkylalkyle inférieur, 2- ou 3-furyle ou 2- ou -3-furyl-(CH2 )m- où m vaut de 2 à 4. On les obtient par acylation d'un octahydro-2,5-méthanobenzoØqõquinoléine-3-carboxylate d'alkyle ou carboxylation d'une octahydro-2,5-méthanobenzoØgõquinoléine. Les composés obtenus ont une activité analgésique et antagoniste de narcotiques.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72537176A | 1976-09-22 | 1976-09-22 | |
US78574677A | 1977-04-08 | 1977-04-08 | |
US05/818,713 US4119628A (en) | 1976-09-22 | 1977-07-25 | Process for preparing hexahydro-11 (eq)-CH2 CH2 COR5 -2,6-methano-3-benzazocines |
DE19782811849 DE2811849A1 (de) | 1976-09-22 | 1978-03-17 | 2,6-methano-3-benzazocine, verfahren zu deren herstellung und arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2378768A1 true FR2378768A1 (fr) | 1978-08-25 |
FR2378768B1 FR2378768B1 (fr) | 1981-05-29 |
Family
ID=27432292
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7728584A Granted FR2375216A1 (fr) | 1976-09-22 | 1977-09-22 | 2,5-methanobenzo (g) quinoleine-3-carboxylates (esters) |
FR7803369A Granted FR2378768A1 (fr) | 1976-09-22 | 1978-02-07 | 2,6-methano-3-benzazocines et leur utilisation comme medicaments |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7728584A Granted FR2375216A1 (fr) | 1976-09-22 | 1977-09-22 | 2,5-methanobenzo (g) quinoleine-3-carboxylates (esters) |
Country Status (10)
Country | Link |
---|---|
US (2) | US4119628A (fr) |
JP (1) | JPS5340777A (fr) |
BE (1) | BE858866A (fr) |
CA (1) | CA1095905A (fr) |
CH (2) | CH624939A5 (fr) |
DE (1) | DE2742715A1 (fr) |
FR (2) | FR2375216A1 (fr) |
GB (1) | GB1551562A (fr) |
LU (1) | LU78162A1 (fr) |
NL (1) | NL187630C (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4255579A (en) * | 1974-05-20 | 1981-03-10 | Sterling Drug Inc. | 11-Substituted hexahydro-2,6-methano-3-benzazocines |
BE864950A (fr) * | 1976-09-22 | 1978-09-18 | Sterling Drug Inc | 2,6-methano-3-benzazocines |
EP0019056A1 (fr) * | 1979-03-26 | 1980-11-26 | Sterling Drug Inc. | Procédé de préparation de 11-alkoxy inférieur et alkylthio inférieur 3-oxo alkyl inférieur-hexahydro-2,6-méthane-3-benzazocines |
US4912114A (en) * | 1988-03-18 | 1990-03-27 | Sandoz Ltd. | Morphinan derivatives |
CA2890655A1 (fr) * | 2012-11-09 | 2014-05-15 | Purdue Pharma L.P. | Analogues de benzomorphane et leur utilisation |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932422A (en) * | 1974-05-20 | 1976-01-13 | Sterling Drug Inc. | 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones |
-
1977
- 1977-07-25 US US05/818,713 patent/US4119628A/en not_active Expired - Lifetime
- 1977-09-19 CA CA286,972A patent/CA1095905A/fr not_active Expired
- 1977-09-19 GB GB38944/77A patent/GB1551562A/en not_active Expired
- 1977-09-20 BE BE1008388A patent/BE858866A/fr not_active IP Right Cessation
- 1977-09-20 NL NLAANVRAGE7710325,A patent/NL187630C/xx not_active IP Right Cessation
- 1977-09-22 CH CH1161877A patent/CH624939A5/fr not_active IP Right Cessation
- 1977-09-22 DE DE19772742715 patent/DE2742715A1/de active Granted
- 1977-09-22 FR FR7728584A patent/FR2375216A1/fr active Granted
- 1977-09-22 LU LU78162A patent/LU78162A1/xx unknown
- 1977-09-22 CH CH81881A patent/CH626882A5/fr not_active IP Right Cessation
- 1977-09-22 JP JP11452077A patent/JPS5340777A/ja active Granted
-
1978
- 1978-02-07 FR FR7803369A patent/FR2378768A1/fr active Granted
- 1978-02-16 US US05/878,308 patent/US4148794A/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932422A (en) * | 1974-05-20 | 1976-01-13 | Sterling Drug Inc. | 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones |
Also Published As
Publication number | Publication date |
---|---|
BE858866A (fr) | 1978-03-20 |
JPS6224424B2 (fr) | 1987-05-28 |
CA1095905A (fr) | 1981-02-17 |
DE2742715A1 (de) | 1978-03-23 |
GB1551562A (en) | 1979-08-30 |
CH624939A5 (fr) | 1981-08-31 |
JPS5340777A (en) | 1978-04-13 |
LU78162A1 (fr) | 1978-06-01 |
CH626882A5 (fr) | 1981-12-15 |
FR2378768B1 (fr) | 1981-05-29 |
FR2375216A1 (fr) | 1978-07-21 |
AU2903077A (en) | 1979-03-29 |
FR2375216B1 (fr) | 1980-09-19 |
NL7710325A (nl) | 1978-03-28 |
US4119628A (en) | 1978-10-10 |
NL187630C (nl) | 1991-12-02 |
NL187630B (nl) | 1991-07-01 |
US4148794A (en) | 1979-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |