FR2373549A1 - Procede de transformation de 3-methylenecephalosporines en 3-heterothiomethylcephalosporines - Google Patents

Procede de transformation de 3-methylenecephalosporines en 3-heterothiomethylcephalosporines

Info

Publication number
FR2373549A1
FR2373549A1 FR7736436A FR7736436A FR2373549A1 FR 2373549 A1 FR2373549 A1 FR 2373549A1 FR 7736436 A FR7736436 A FR 7736436A FR 7736436 A FR7736436 A FR 7736436A FR 2373549 A1 FR2373549 A1 FR 2373549A1
Authority
FR
France
Prior art keywords
methylenecephalosporins
heterothiomethylcephalosporins
transformation
heterothiomethylcephalosporanic
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7736436A
Other languages
English (en)
Other versions
FR2373549B1 (fr
Inventor
William A Slusarchyk
Eric M Gordon
William H Koster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2373549A1 publication Critical patent/FR2373549A1/fr
Application granted granted Critical
Publication of FR2373549B1 publication Critical patent/FR2373549B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la préparation d'esters d'acides 3-hétérothiométhylcéphalosporaniques de formule :
FR7736436A 1976-12-08 1977-12-02 Procede de transformation de 3-methylenecephalosporines en 3-heterothiomethylcephalosporines Granted FR2373549A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/748,426 US4129731A (en) 1976-12-08 1976-12-08 Process for converting 3-methylene cephalosporins to 3-heterothiomethyl cephalosporins

Publications (2)

Publication Number Publication Date
FR2373549A1 true FR2373549A1 (fr) 1978-07-07
FR2373549B1 FR2373549B1 (fr) 1980-12-05

Family

ID=25009398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7736436A Granted FR2373549A1 (fr) 1976-12-08 1977-12-02 Procede de transformation de 3-methylenecephalosporines en 3-heterothiomethylcephalosporines

Country Status (11)

Country Link
US (1) US4129731A (fr)
JP (1) JPS5373597A (fr)
AU (1) AU511186B2 (fr)
BE (1) BE861639A (fr)
CA (1) CA1087169A (fr)
CH (1) CH626089A5 (fr)
DE (1) DE2754742C2 (fr)
FR (1) FR2373549A1 (fr)
GB (1) GB1591460A (fr)
IE (1) IE46175B1 (fr)
NL (1) NL7712900A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4311837A (en) * 1979-05-01 1982-01-19 Eli Lilly And Company Certain heterocyclic thiomethyl derivatives of 7-(dihalogenated phenylthioacetamido)cephalosporanic acids useful in the treatment of infections caused by _Streptococcus faecalis
NL8005041A (nl) * 1980-09-05 1982-04-01 Gist Brocades Nv Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275626A (en) * 1962-07-31 1966-09-27 Lilly Co Eli Penicillin conversion via sulfoxide
US3929775A (en) * 1970-12-08 1975-12-30 Takeda Chemical Industries Ltd Process for producing cephalosporin derivatives
US3932393A (en) * 1971-02-25 1976-01-13 Eli Lilly And Company 3-Methylenecephalosporins and process for production thereof
JPS515396B1 (fr) * 1971-04-05 1976-02-19
US3883518A (en) * 1972-05-15 1975-05-13 Merck & Co Inc 3-Methylene cephalosporins
US3962227A (en) * 1973-02-23 1976-06-08 Eli Lilly And Company 3-halo cephalosporins
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
US3941779A (en) * 1973-11-12 1976-03-02 E. R. Squibb & Sons, Inc. Method for producing 2-(substituted thio)-3-cephem derivatives
US3968109A (en) * 1973-11-23 1976-07-06 E. R. Squibb & Sons, Inc. Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4039534A (en) * 1975-11-17 1977-08-02 E. R. Squibb & Sons, Inc. 4-Thio substituted-Δ2 -cephalosporin intermediates

Also Published As

Publication number Publication date
DE2754742C2 (de) 1986-04-30
CH626089A5 (fr) 1981-10-30
JPS5373597A (en) 1978-06-30
AU3038677A (en) 1979-05-17
DE2754742A1 (de) 1978-06-15
JPS6118554B2 (fr) 1986-05-13
US4129731A (en) 1978-12-12
CA1087169A (fr) 1980-10-07
IE46175L (en) 1978-06-08
FR2373549B1 (fr) 1980-12-05
NL7712900A (nl) 1978-06-12
GB1591460A (en) 1981-06-24
AU511186B2 (en) 1980-07-31
IE46175B1 (en) 1983-03-23
BE861639A (fr) 1978-06-08

Similar Documents

Publication Publication Date Title
FR2421874A1 (fr) Carboxyalkylacylamino-acides utiles comme agents hypotenseurs
FR2422637A1 (fr) Nouveaux derives de l'acide 2(4-thio-2-oxo-azetidin-1-yl)-3-methylene-butyrique et procede de preparation
FR2371449A1 (fr) Acide 1-carba-2-penem-3-carboxylique
FR2379506A1 (fr) Nouveaux esters d'acide cycloproprane carboxylique d'alcools benzyliques halogenes, leur procede de preparation et leur application comme insecticides et acaricides
FR2416218A1 (fr) Procede de preparation de n-(p-aminobenzoyl) glutamates de dialkyle
FR2383907A1 (fr) Procede de preparation de derives de l'acide acetique et derives obtenus par ce procede
BE865124A (fr) Procede de preparation d'esters d'acides butane-dicarboxyliques
FR2355796A1 (fr) Procede de preparation de fluorures d'acides perfluoro-alcoxy-propioniques
FR2372817A1 (fr) Derives d'acides thiazolidinecarboxyliques et d'acides apparentes, utiles comme agents anti-hypertension
FR2433504A1 (fr) Procede de preparation de derives du biphenyle
FR2445834A1 (fr) Derives heterobicycliques de l'acide 7-acylamido-3-cephem-4-carboxylique insature, procedes de preparation de ceux-ci et utilisation en therapeutique
FR2383158A1 (fr) Procede de production d'acides dihalogenovinyl-cyclopropane-carboxyliques et leurs esters
FR2375253A1 (fr) Preparations de g-lactones d'acides 7x-(alcoxycarbonyl)-6x -alkyl/halog 17-hydroxy-3-oxo-17a -pregn-4-ene-21-carboxyliques, des acides 21-carboxyliques correspondants, de leurs sels et esters, et leur utilisation therapeutique comme diuretiques
FR2377367A1 (fr) Procede de preparation d'alcoxy-cetones
FR2361341A1 (fr) Procede de preparation d'esters de l'acide anthranilique
FR2375230A1 (fr) Preparation d'esters de l'acide bromo-5 nicotinique
FR2354339A1 (fr) Procede de preparation d'acides 1-aminoalcane-1,1-diphosphoniques
FR2373549A1 (fr) Procede de transformation de 3-methylenecephalosporines en 3-heterothiomethylcephalosporines
FR2446841A1 (fr) Procede de preparation de 1a,3b-dihydroxy-d5-steroides
FR2372835A1 (fr) Nouveaux derives d'acide polyparabanique et leur procede de preparation
FR2433009A1 (fr) Procede pour la preparation de dicyclopentylene(2,2'-bis(4-alkyl-6-t-butylphenols))
FR2397427A1 (fr) Derives de steroide et leur procede de preparation
FR2429211A1 (fr) Procede de production de derives de n-methylbenzothiazolone substitues en position 4
FR2364923A1 (fr) Nouveaux amides d'esters phosphorique, leur procede de preparation et leur application comme insecticides et acaricides
FR2359133A1 (fr) Procede de preparation de (vinyl 2,2-disubstitue)-g-butyrolactones

Legal Events

Date Code Title Description
ST Notification of lapse