FR2373516A1 - Nouveaux derives de l'inhibiteur de trypsine et de kallicreine d'organes de boeuf a effet antiproteolytique et anti-inflammatoire, leur procede de preparation et medicaments les contenant - Google Patents
Nouveaux derives de l'inhibiteur de trypsine et de kallicreine d'organes de boeuf a effet antiproteolytique et anti-inflammatoire, leur procede de preparation et medicaments les contenantInfo
- Publication number
- FR2373516A1 FR2373516A1 FR7735774A FR7735774A FR2373516A1 FR 2373516 A1 FR2373516 A1 FR 2373516A1 FR 7735774 A FR7735774 A FR 7735774A FR 7735774 A FR7735774 A FR 7735774A FR 2373516 A1 FR2373516 A1 FR 2373516A1
- Authority
- FR
- France
- Prior art keywords
- trypsin
- inhibitor
- derivatives
- kallicrein
- antiproteolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004142 Trypsin Human genes 0.000 title abstract 2
- 108090000631 Trypsin Proteins 0.000 title abstract 2
- 210000000056 organ Anatomy 0.000 title abstract 2
- 239000012588 trypsin Substances 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 230000000636 anti-proteolytic effect Effects 0.000 title 1
- 235000015278 beef Nutrition 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 101000984722 Bos taurus Pancreatic trypsin inhibitor Proteins 0.000 abstract 4
- 125000000751 azo group Chemical group [*]N=N[*] 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 101000975003 Homo sapiens Kallistatin Proteins 0.000 abstract 1
- 101001077723 Homo sapiens Serine protease inhibitor Kazal-type 6 Proteins 0.000 abstract 1
- 229940122920 Kallikrein inhibitor Drugs 0.000 abstract 1
- 102100023012 Kallistatin Human genes 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19762654124 DE2654124A1 (de) | 1976-11-29 | 1976-11-29 | Derivate des trypsin-kallikrein-inhibitors aus rinderorganen (bpti) mit proteasenhemmwirkung und antiphlogistischer wirkung, ihre herstellung und ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2373516A1 true FR2373516A1 (fr) | 1978-07-07 |
| FR2373516B1 FR2373516B1 (cg-RX-API-DMAC7.html) | 1980-06-13 |
Family
ID=5994225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7735774A Granted FR2373516A1 (fr) | 1976-11-29 | 1977-11-28 | Nouveaux derives de l'inhibiteur de trypsine et de kallicreine d'organes de boeuf a effet antiproteolytique et anti-inflammatoire, leur procede de preparation et medicaments les contenant |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4153687A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5368701A (cg-RX-API-DMAC7.html) |
| BE (1) | BE861267A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2654124A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK526077A (cg-RX-API-DMAC7.html) |
| ES (1) | ES464571A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2373516A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1557599A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7713091A (cg-RX-API-DMAC7.html) |
| SE (1) | SE7713436L (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2748294A1 (de) * | 1977-10-27 | 1979-05-03 | Bayer Ag | Neue derivate des bpti, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2748295A1 (de) * | 1977-10-27 | 1979-05-03 | Bayer Ag | Neue derivate des bpti |
| RU2054180C1 (ru) * | 1991-08-21 | 1996-02-10 | Жирнов Олег Петрович (н/п) | Способ лечения вирусных респираторных инфекций |
| CA2180950C (en) * | 1994-01-11 | 2005-03-29 | William Markland | Kallikrein-inhibiting "kunitz domain" proteins and analogues thereof |
| US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| PT737207E (pt) * | 1994-01-11 | 2005-02-28 | Dyax Corp | Inibidores de plasmina humana derivados de dominios kunitz |
| US20040054082A1 (en) * | 2001-12-03 | 2004-03-18 | Bank David H | Toughened polymer blends with improved surface properties |
| EP2298278B1 (en) | 2002-06-07 | 2015-11-11 | Dyax Corp. | Prevention and reduction of blood loss and inflammatory response |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| ES2395014T3 (es) | 2002-08-28 | 2013-02-07 | Dyax Corp. | Métodos para conservar órganos y tejidos |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| US7276480B1 (en) | 2005-12-30 | 2007-10-02 | Dyax Corp. | Prevention and reduction of blood loss |
| JP2009529542A (ja) * | 2006-03-10 | 2009-08-20 | ダイアックス コーポレーション | エカランチドに関する配合物 |
| AU2010203712A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| ES2905545T3 (es) | 2010-01-06 | 2022-04-11 | Takeda Pharmaceuticals Co | Proteínas de unión a calicreína plasmática |
| CN105713092B (zh) | 2011-01-06 | 2019-09-10 | 戴埃克斯有限公司 | 血浆前激肽释放酶结合蛋白 |
| WO2012170945A2 (en) | 2011-06-10 | 2012-12-13 | Isis Pharmaceuticals, Inc. | Methods for modulating kallikrein (klkb1) expression |
| CA2840614A1 (en) | 2011-06-29 | 2013-01-03 | Isis Pharmaceuticals, Inc. | Methods for modulating kallikrein (klkb1) expression |
| RU2712559C9 (ru) | 2013-08-28 | 2020-10-08 | Ионис Фармасьютикалз, Инк. | Модуляция экспрессии прекалликреина (пкк) |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| EP4534092A3 (en) | 2014-05-01 | 2025-07-02 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating pkk expression |
| BR112018011622A2 (pt) | 2015-12-11 | 2018-11-27 | Dyax Corp | método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae |
-
1976
- 1976-11-29 DE DE19762654124 patent/DE2654124A1/de active Pending
-
1977
- 1977-11-02 US US05/847,886 patent/US4153687A/en not_active Expired - Lifetime
- 1977-11-25 JP JP14083877A patent/JPS5368701A/ja active Pending
- 1977-11-25 GB GB49159/77A patent/GB1557599A/en not_active Expired
- 1977-11-28 SE SE7713436A patent/SE7713436L/ unknown
- 1977-11-28 BE BE182978A patent/BE861267A/xx unknown
- 1977-11-28 FR FR7735774A patent/FR2373516A1/fr active Granted
- 1977-11-28 NL NL7713091A patent/NL7713091A/xx not_active Application Discontinuation
- 1977-11-28 DK DK526077A patent/DK526077A/da unknown
- 1977-11-29 ES ES464571A patent/ES464571A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2654124A1 (de) | 1978-06-01 |
| DK526077A (da) | 1978-05-30 |
| GB1557599A (en) | 1979-12-12 |
| JPS5368701A (en) | 1978-06-19 |
| NL7713091A (nl) | 1978-05-31 |
| FR2373516B1 (cg-RX-API-DMAC7.html) | 1980-06-13 |
| US4153687A (en) | 1979-05-08 |
| BE861267A (fr) | 1978-05-29 |
| SE7713436L (sv) | 1978-05-30 |
| ES464571A1 (es) | 1978-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |