FR2373290A1 - Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique - Google Patents

Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique

Info

Publication number
FR2373290A1
FR2373290A1 FR7737046A FR7737046A FR2373290A1 FR 2373290 A1 FR2373290 A1 FR 2373290A1 FR 7737046 A FR7737046 A FR 7737046A FR 7737046 A FR7737046 A FR 7737046A FR 2373290 A1 FR2373290 A1 FR 2373290A1
Authority
FR
France
Prior art keywords
physiological solution
charged cells
mass
preparation
suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7737046A
Other languages
English (en)
Other versions
FR2373290B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungszentrum Juelich GmbH
Original Assignee
Kernforschungsanlage Juelich GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kernforschungsanlage Juelich GmbH filed Critical Kernforschungsanlage Juelich GmbH
Publication of FR2373290A1 publication Critical patent/FR2373290A1/fr
Application granted granted Critical
Publication of FR2373290B1 publication Critical patent/FR2373290B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/18—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

a. Procédé pour la préparation d'une masse de cellules chargées en suspension dans une solution physiologique. b. On ajoute à la solution physiologique prévue pour l'échange de matières des substances magnétiques dont le diamètre est compris entre 1 et 20 nm et qui sont destinées à être reçues à l'intérieur des cellules chargées, en même temps que les matières et les cellules présentant une membrane cellulaire à perméabilité élevée, la quantité de substances magnétiques ajoutées étant telle que les cellules chargées sont maintenues par un champ magnétique extérieur agissant sur elles en un endroit déterminé de la solution physiologique. c. Médecine.
FR7737046A 1976-12-11 1977-12-08 Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique Granted FR2373290A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2656317A DE2656317C2 (de) 1976-12-11 1976-12-11 Verfahren zur Herstellung einer Suspension von beladenen Erythrocyten

Publications (2)

Publication Number Publication Date
FR2373290A1 true FR2373290A1 (fr) 1978-07-07
FR2373290B1 FR2373290B1 (fr) 1983-09-23

Family

ID=5995351

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7737046A Granted FR2373290A1 (fr) 1976-12-11 1977-12-08 Procede pour la preparation d'une masse de cellules chargees en suspension dans une solution physiologique

Country Status (8)

Country Link
US (1) US4269826A (fr)
JP (1) JPS5396382A (fr)
CH (1) CH632412A5 (fr)
DE (1) DE2656317C2 (fr)
FR (1) FR2373290A1 (fr)
GB (1) GB1560166A (fr)
IL (1) IL53595A (fr)
SE (1) SE445423B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2529463A1 (fr) * 1982-07-05 1984-01-06 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4345588A (en) * 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
JPS5661992A (en) * 1979-10-24 1981-05-27 Kibun Kk Fermentation and/or aging method
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4392040A (en) * 1981-01-09 1983-07-05 Rand Robert W Induction heating apparatus for use in causing necrosis of neoplasm
US4558690A (en) * 1982-01-26 1985-12-17 University Of Scranton Method of administration of chemotherapy to tumors
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US4622952A (en) * 1983-01-13 1986-11-18 Gordon Robert T Cancer treatment method
US4545368A (en) * 1983-04-13 1985-10-08 Rand Robert W Induction heating method for use in causing necrosis of neoplasm
US4590922A (en) * 1983-08-19 1986-05-27 Gordon Robert T Use of ferromagnetic, paramagnetic and diamagnetic particles in the treatment of infectious diseases
US4829984A (en) * 1983-12-15 1989-05-16 Gordon Robert T Method for the improvement of transplantation techniques and for the preservation of tissue
US4610241A (en) * 1984-07-03 1986-09-09 Gordon Robert T Atherosclerosis treatment method
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
US4983159A (en) * 1985-03-25 1991-01-08 Rand Robert W Inductive heating process for use in causing necrosis of neoplasms at selective frequencies
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US5019372A (en) * 1986-06-27 1991-05-28 The Children's Medical Center Corporation Magnetically modulated polymeric drug release system
US4770183A (en) * 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
US4950221A (en) * 1986-07-18 1990-08-21 Gordon Robert T Process for affecting molecules in tissue
US4996991A (en) * 1986-07-18 1991-03-05 Gordon Robert T Method for following the distribution of particles in neurological or neuromuscular tissue and cells
US4923437A (en) * 1986-07-18 1990-05-08 Gordon Robert T Process for applying a localized magnetic or electric field
US4869247A (en) * 1988-03-11 1989-09-26 The University Of Virginia Alumni Patents Foundation Video tumor fighting system
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
US4935223A (en) * 1988-08-04 1990-06-19 Board Of Regents, The University Of Texas System Labeled cells for use in imaging
DE3925680A1 (de) * 1989-08-03 1991-02-07 Kruess Gmbh Wissenschaftliche Verfahren zur herstellung vitaler wirkstoff-beladener humanerythrozyten
US5304382A (en) * 1989-08-18 1994-04-19 Monsanto Company Ferritin analogs
SU1722256A3 (ru) * 1989-11-02 1992-03-23 Viktor A Volkonskij Cпocoб пoлучehия maгhиtoупpabляemoй диcпepcии
US5125888A (en) * 1990-01-10 1992-06-30 University Of Virginia Alumni Patents Foundation Magnetic stereotactic system for treatment delivery
US5443813A (en) * 1991-06-06 1995-08-22 Associated Universities, Inc. Loading and conjugating cavity biostructures
US6374670B1 (en) * 1995-03-13 2002-04-23 University Of Washington Non-invasive gut motility monitor
US6447499B2 (en) 1995-07-28 2002-09-10 James R. Gray Use of a polarized field to modify the efficacy of a bioactive agent
US6815063B1 (en) 1996-11-16 2004-11-09 Nanomagnetics, Ltd. Magnetic fluid
US20060003163A1 (en) * 1996-11-16 2006-01-05 Nanomagnetics Limited Magnetic fluid
US6713173B2 (en) * 1996-11-16 2004-03-30 Nanomagnetics Limited Magnetizable device
US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
GB2319253A (en) 1996-11-16 1998-05-20 Eric Leigh Mayes Composition, for use in a device, comprising a magnetic layer of domain-separated magnetic particles
EP0882448B1 (fr) * 1997-05-05 2005-01-12 DIDECO S.r.l. Méthode d'encapsulation d'agents biologiquement actifs dans des erythrocytes et appareil
US6135118A (en) * 1997-05-12 2000-10-24 Dailey; James P. Treatment with magnetic fluids
US6203487B1 (en) * 1997-12-31 2001-03-20 Thomas Jefferson University Use of magnetic particles in the focal delivery of cells
WO2000006244A2 (fr) * 1998-07-30 2000-02-10 Hainfeld James F Particules metalliques de chargement dans des vesicules membranaires cellulaires et particule metallique utilisee pour l'imagerie et la therapie
US20060041182A1 (en) * 2003-04-16 2006-02-23 Forbes Zachary G Magnetically-controllable delivery system for therapeutic agents
US6972095B1 (en) 2003-05-07 2005-12-06 Electric Power Research Institute Magnetic molecules: a process utilizing functionalized magnetic ferritins for the selective removal of contaminants from solution by magnetic filtration
US8986736B2 (en) * 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
AU2004249172A1 (en) * 2003-06-24 2004-12-29 Baxter International Inc. Specific delivery of drugs to the brain
KR20060135729A (ko) * 2004-01-29 2006-12-29 백스터 인터내셔널 인코포레이티드 중추신경계 전달 증가를 위한 항레트로바이러스제의나노현탁액
US20070100457A1 (en) * 2004-03-04 2007-05-03 Hyde Edward R Jr Paramagnetic liquid interface
KR20070037444A (ko) * 2004-06-15 2007-04-04 백스터 인터내셔널 인코포레이티드 고체 미립자성 치료제의 생체외 적용방법
DE102004054536A1 (de) * 2004-11-06 2006-05-11 Capsulution Nanoscience Ag Multimodal veränderte Zellen als zellulare Darreichungsformen für aktive Substanzen und als diagnostische Zellpartikel
EP1849482A1 (fr) * 2006-04-25 2007-10-31 Capsulution Nanoscience AG Cellules multi-modalement modifiées comme formes pour l' administration de substances actives et comme particules diagnostiques
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
GB0621894D0 (en) * 2006-11-02 2006-12-13 Iti Scotland Ltd Magnetic recognition system
EP2259798B1 (fr) 2008-03-05 2013-12-11 Baxter International Inc. Compositions et procédés d administration de médicament
GB0808090D0 (en) * 2008-05-02 2008-06-11 Iti Scotland Ltd Use of magnetic proteins in medicine
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
US20120061317A1 (en) * 2010-09-13 2012-03-15 Beng Joo Reginald Thio Magnetic Pollen Grains as Sorbents for Organic Pollutants in Aqueous Media

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474777A (en) * 1966-02-10 1969-10-28 Amp Inc Method of administering therapeutic agents
FR2230722A1 (fr) * 1973-05-23 1974-12-20 Kernforschungsanlage Juelich

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700555A (en) * 1970-10-12 1972-10-24 Technicon Instr Method and apparatus for lymphocyte separation from blood
US3709791A (en) * 1971-04-13 1973-01-09 Technicon Instr Method and apparatus for lymphocyte separation from blood
US3887698A (en) * 1973-03-12 1975-06-03 Univ Leland Stanford Junior Sacs with epitopic sites on walls enclosing stable free radicals

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474777A (en) * 1966-02-10 1969-10-28 Amp Inc Method of administering therapeutic agents
FR2230722A1 (fr) * 1973-05-23 1974-12-20 Kernforschungsanlage Juelich

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1974 *
CA1977 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2529463A1 (fr) * 1982-07-05 1984-01-06 Centre Nat Rech Scient Procede et dispositif pour l'encapsulation dans les erythrocytes d'au moins une substance a activite biologique, notamment des effecteurs allosteriques de l'hemoglobine et erythrocytes ainsi obtenus
EP0101341A1 (fr) * 1982-07-05 1984-02-22 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Procédé et dispositif pour l'encapsulation dans les érythrocytes d'au moins une substance à activité biologique, notamment des effecteurs allostériques de l'hémoglobine et érythrocytes ainsi obtenus

Also Published As

Publication number Publication date
GB1560166A (en) 1980-01-30
DE2656317A1 (de) 1978-06-22
JPS5396382A (en) 1978-08-23
DE2656317C2 (de) 1986-06-19
FR2373290B1 (fr) 1983-09-23
IL53595A (en) 1981-06-29
SE445423B (sv) 1986-06-23
US4269826A (en) 1981-05-26
SE7713945L (sv) 1978-06-12
CH632412A5 (de) 1982-10-15

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