FR2370722B1 - - Google Patents

Info

Publication number
FR2370722B1
FR2370722B1 FR7733970A FR7733970A FR2370722B1 FR 2370722 B1 FR2370722 B1 FR 2370722B1 FR 7733970 A FR7733970 A FR 7733970A FR 7733970 A FR7733970 A FR 7733970A FR 2370722 B1 FR2370722 B1 FR 2370722B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7733970A
Other versions
FR2370722A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2370722A1 publication Critical patent/FR2370722A1/fr
Application granted granted Critical
Publication of FR2370722B1 publication Critical patent/FR2370722B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
FR7733970A 1976-11-12 1977-11-10 Nouveaux benzamides trans-n-(2-aminocycloaliphatiques), leur procede de preparation et medicament les contenant Granted FR2370722A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/741,467 US4098904A (en) 1976-11-12 1976-11-12 Analgesic n-(2-aminocycloaliphatic)benzamides

Publications (2)

Publication Number Publication Date
FR2370722A1 FR2370722A1 (fr) 1978-06-09
FR2370722B1 true FR2370722B1 (fr) 1981-12-04

Family

ID=24980833

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7733970A Granted FR2370722A1 (fr) 1976-11-12 1977-11-10 Nouveaux benzamides trans-n-(2-aminocycloaliphatiques), leur procede de preparation et medicament les contenant

Country Status (12)

Country Link
US (4) US4098904A (fr)
JP (1) JPS5363352A (fr)
AU (1) AU515054B2 (fr)
BE (1) BE860727A (fr)
CA (1) CA1072558A (fr)
CH (1) CH643817A5 (fr)
DE (1) DE2749984A1 (fr)
ES (1) ES463877A1 (fr)
FR (1) FR2370722A1 (fr)
GB (1) GB1588460A (fr)
NL (1) NL7711934A (fr)
ZA (1) ZA776240B (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179501A (en) * 1976-11-12 1979-12-18 The Upjohn Company Analgesic N-(2-aminocycloaliphatic)azidobenzamides
US4217362A (en) * 1976-11-30 1980-08-12 The Upjohn Company Anilide derivatives as antidepressants
US4212878A (en) * 1978-01-26 1980-07-15 The Upjohn Company Phenylacetamide derivative analgesics
US4346101A (en) * 1980-12-08 1982-08-24 The Upjohn Company Benzamide derivative analgesics
US4460600A (en) * 1981-04-09 1984-07-17 The Upjohn Company Adjacently substituted ketal derivatives of cycloalkane-amide analgesics
US4466977A (en) * 1981-04-09 1984-08-21 The Upjohn Company N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics
US4359476A (en) * 1981-04-09 1982-11-16 The Upjohn Company Adjacently substituted cycloalkane-amide analgesics
US4360531A (en) * 1981-04-09 1982-11-23 The Upjohn Company Substituted cycloalkanes
US4540690A (en) * 1982-02-09 1985-09-10 The Upjohn Company 2-(Phenylmethylene)cycloalkylamines and -azetidines
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US4652559A (en) * 1982-08-16 1987-03-24 The Upjohn Company 2-(Phenylmethylene)cycloalkyl-azetidines
AT376669B (de) * 1982-11-26 1984-12-27 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thienylessigsaeureamid-derivate und pharmazeutisch vertraeglicher saeureadditionssalze davon
US4598088A (en) * 1983-05-18 1986-07-01 The Upjohn Company 2-pyrrolyl-cycloalkyl-amide analgesics
ZA842753B (en) * 1983-05-18 1984-11-28 Upjohn Co 2-dihydropyrrolyl-cycloalkyl-amide analgesics
US4560767A (en) * 1983-06-17 1985-12-24 The Upjohn Company N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom
US4579863A (en) * 1983-12-06 1986-04-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4598087A (en) * 1983-12-06 1986-07-01 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4588591A (en) * 1984-05-25 1986-05-13 The Upjohn Company Analgesic 2-oxa-spirocyclic compounds
US4632935A (en) * 1984-05-30 1986-12-30 The Upjohn Company Omega-(hydroxy-, ether and ester)-alkyl-2-amino-cycloalkyl- and cycloalkenyl amides as analgesics
US4677122A (en) * 1984-11-13 1987-06-30 Warner-Lambert Company Substituted trans-1,2-diaminocyclohexyl amide compounds
US4737493A (en) 1985-07-01 1988-04-12 Warner-Lambert Company 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents
US4663343A (en) * 1985-07-19 1987-05-05 Warner-Lambert Company Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds
US4663335A (en) * 1985-10-25 1987-05-05 The Upjohn Company Trans-(+)-2-(3,4-dichlorophenyl)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]ac
DE3668268D1 (de) * 1985-10-25 1990-02-22 Upjohn Co Verwendung von cis-n-(2-aminocycloaliphatische) benzen acetamid und benzamid zur herstellung von antikrampfmittel.
US4801604A (en) * 1985-10-25 1989-01-31 The Upjohn Company Cis-N-(2-aminocycloaliphatic)benzamide anti-convulsants
FR2592879B1 (fr) * 1986-01-13 1988-04-29 Roussel Uclaf Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant
ZA876778B (en) * 1986-09-10 1989-05-30 Du Pont Benzo-fused cycloalkane and oxa-and thia-,cycloalkane trans-1,2-diamine derivatives
US4876269A (en) * 1986-09-10 1989-10-24 E. I. Du Pont De Nemours And Company Benoz-fused cycloalkane trans-1,2-diamine derivatives
US5043350A (en) * 1986-09-10 1991-08-27 Du Pont Merck Pharmaceutical Company Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,2-diamine derivatives
FR2608598B1 (fr) * 1986-12-23 1989-04-14 Roussel Uclaf Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
US5051428A (en) * 1988-12-06 1991-09-24 Warner-Lambert Company 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
FR2674849B1 (fr) * 1991-04-02 1994-12-23 Logeais Labor Jacques Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
US5475019A (en) * 1993-02-08 1995-12-12 East Carolina University Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds
US6750216B2 (en) * 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6303611B1 (en) 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5688955A (en) * 1996-03-08 1997-11-18 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6057323A (en) * 1996-03-08 2000-05-02 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
USRE38133E1 (en) * 1996-03-08 2003-06-03 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
JP2003502296A (ja) * 1999-06-15 2003-01-21 ロディア・シミ スルホニルアミド及びカルボキサミド並びに不斉触媒作用におけるそれらの使用
FR2795070A1 (fr) * 1999-06-15 2000-12-22 Rhodia Chimie Sa Nouveaux composes de type diamine mono- ou poly- fluore, sulfonyle ou carbonyle, leur procede de preparation et leur application en catalyse asymetrique
FR2800371B1 (fr) * 1999-10-29 2003-04-25 Rhodia Chimie Sa Nouveaux composes de type diamine mono- ou poly- fluore, sulfonyle ou carbonyle, leur procede de preparation et leur application en catalyse asymetrique
CA2315815A1 (fr) 2000-07-19 2002-01-19 Peter R. Ford Composition et support d'analgesique topique
CA2459364A1 (fr) * 2001-09-13 2003-03-20 F. Hoffmann-La Roche Ag Antagonistes v du recepteur ccr-3
US6852713B2 (en) * 2003-04-16 2005-02-08 Adolor Corporation Lactam derivatives and methods of their use
US6992193B2 (en) 2003-06-10 2006-01-31 Adolor Corporation Sulfonylamino phenylacetamide derivatives and methods of their use
US7034051B2 (en) * 2003-08-28 2006-04-25 Adolor Corporation Fused bicyclic carboxamide derivatives and methods of their use
US7160902B2 (en) * 2003-11-14 2007-01-09 Adolor Corporation Amide derivatives and methods of their use
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US8080541B2 (en) * 2009-08-27 2011-12-20 Hoffman-La Roche Inc. Carbocyclic GlyT-1 receptor antagonists
CN102531918B (zh) * 2012-01-18 2013-10-02 安阳工学院 一种对映纯对称反式二烷基环己胺的合成方法
CN102731316B (zh) * 2012-05-21 2014-04-16 南通市华峰化工有限责任公司 一种1，2-n，n`二甲基环己二胺的生产方法
CN106631815B (zh) * 2016-10-13 2018-10-09 上海瀚鸿科技股份有限公司 一种合成反式环己二胺的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3499033A (en) * 1967-01-06 1970-03-03 Upjohn Co Ethers of alpha-phenyl-2-aminocycloalkanemethanols
US3373195A (en) * 1967-03-07 1968-03-12 Squibb & Sons Inc 2-substituted aminomethylcyclooctyl amides of alkyl substituted acetic acid
US3510492A (en) * 1968-05-13 1970-05-05 Upjohn Co 2-anilino and 2-anilinomethyl cycloalkylamines
US3647804A (en) * 1970-02-27 1972-03-07 Upjohn Co Cycloalkanecarboxamides
US3847982A (en) * 1970-07-15 1974-11-12 Upjohn Co Oxygenated n-benzoyl-n,2,3,3-tetramethyl-exo-2-norbornanamines
US3825595A (en) * 1971-03-12 1974-07-23 Univ Toledo N-cyclopentyl-n-2-hydroxyalkyl-ring-substituted benzamides
US3975443A (en) * 1972-06-06 1976-08-17 Allen & Hanburys Limited 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine
SE404186B (sv) * 1975-06-09 1978-09-25 Astra Laekemedel Ab Forfarande for framstellning av cyklopropanolderivat

Also Published As

Publication number Publication date
CH643817A5 (de) 1984-06-29
CA1072558A (fr) 1980-02-26
GB1588460A (en) 1981-04-23
AU2984077A (en) 1979-04-26
US4098904A (en) 1978-07-04
US4153717A (en) 1979-05-08
ZA776240B (en) 1978-07-26
BE860727A (fr) 1978-05-10
FR2370722A1 (fr) 1978-06-09
ES463877A1 (es) 1978-12-16
NL7711934A (nl) 1978-05-17
US4152459A (en) 1979-05-01
DE2749984A1 (de) 1978-05-18
DE2749984C2 (fr) 1988-04-14
AU515054B2 (en) 1981-03-12
US4148914A (en) 1979-04-10
JPS5363352A (en) 1978-06-06
JPS6148494B2 (fr) 1986-10-24

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Legal Events

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ST Notification of lapse