FR2370472A2 - Amino-alcool heterocyclique, son sel et son procede de preparation - Google Patents
Amino-alcool heterocyclique, son sel et son procede de preparationInfo
- Publication number
- FR2370472A2 FR2370472A2 FR7634001A FR7634001A FR2370472A2 FR 2370472 A2 FR2370472 A2 FR 2370472A2 FR 7634001 A FR7634001 A FR 7634001A FR 7634001 A FR7634001 A FR 7634001A FR 2370472 A2 FR2370472 A2 FR 2370472A2
- Authority
- FR
- France
- Prior art keywords
- substd
- phenyl
- alkyl
- alkanoyl
- mono
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 Heterocyclic aminoalcohol Chemical class 0.000 title abstract 3
- 230000002048 spasmolytic effect Effects 0.000 title abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Polymers 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- VMZUJJGAJWYSBO-UHFFFAOYSA-N 1-(3,4-dihydro-2h-thiochromen-6-yl)propan-1-one Chemical compound S1CCCC2=CC(C(=O)CC)=CC=C21 VMZUJJGAJWYSBO-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000002785 anti-thrombosis Effects 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000000812 cholinergic antagonist Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- IOQPZZOEVPZRBK-UHFFFAOYSA-N octan-1-amine Chemical compound CCCCCCCCN IOQPZZOEVPZRBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000810 peripheral vasodilating agent Substances 0.000 abstract 1
- 229960002116 peripheral vasodilator Drugs 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/08—Six-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7634001A FR2370472A2 (fr) | 1976-11-10 | 1976-11-10 | Amino-alcool heterocyclique, son sel et son procede de preparation |
| NO763917A NO147748C (no) | 1975-11-18 | 1976-11-17 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive aminoalkoholderivater |
| OA56080A OA05578A (fr) | 1976-08-31 | 1977-02-19 | Dérivés d'amino-alcools, composition pharmaceutique à base de ces dérivés ainsi que leur procédé de préparation et leur utilisation. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7634001A FR2370472A2 (fr) | 1976-11-10 | 1976-11-10 | Amino-alcool heterocyclique, son sel et son procede de preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2370472A2 true FR2370472A2 (fr) | 1978-06-09 |
| FR2370472B2 FR2370472B2 (cs) | 1982-01-08 |
Family
ID=9179774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7634001A Granted FR2370472A2 (fr) | 1975-11-18 | 1976-11-10 | Amino-alcool heterocyclique, son sel et son procede de preparation |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2370472A2 (cs) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062919A1 (de) * | 1981-04-13 | 1982-10-20 | Schering Aktiengesellschaft | Neue Indol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate, die diese Verbindungen enthalten |
| EP0099766A1 (fr) * | 1982-06-03 | 1984-02-01 | Roussel-Uclaf | Nouveaux dérivés de la 1,3-dihydro 4-(1-hydroxy 2-aminoéthyl) 2H-indol-2-one, leurs sels, procédé de préparation, application à titre de médicaments et compositions les renfermant |
| US4521606A (en) * | 1983-06-30 | 1985-06-04 | American Home Products Corp. | 5-Indolyl substituted aminoethanols |
| US4562200A (en) * | 1983-06-30 | 1985-12-31 | American Home Products Corporation | 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives |
| US4622399A (en) * | 1983-06-30 | 1986-11-11 | American Home Products Corporation | Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives |
| WO1987002359A1 (en) * | 1985-10-14 | 1987-04-23 | Maggioni-Winthrop S.P.A. | Dihydrobenzothiophene and thiochromane aminoalcohols |
| EP0177245A3 (en) * | 1984-09-28 | 1987-07-01 | Nippon Chemiphar Co., Ltd. | Amino-alcohol derivatives and processes for their preparation |
| WO1996003396A1 (en) * | 1994-07-27 | 1996-02-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1997017324A1 (fr) * | 1995-11-10 | 1997-05-15 | Rhodia Chimie | Procede d'acylation d'un thioether aromatique |
| US5656661A (en) * | 1994-07-27 | 1997-08-12 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5672620A (en) * | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1998008834A1 (fr) * | 1996-08-29 | 1998-03-05 | Synthelabo | Derives de benzylamine, leur preparation et leur application en therapeutique |
| FR2752840A1 (fr) * | 1996-08-29 | 1998-03-06 | Synthelabo | Derives de benzothiophene, leur preparation et leur application en therapeutique |
-
1976
- 1976-11-10 FR FR7634001A patent/FR2370472A2/fr active Granted
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062919A1 (de) * | 1981-04-13 | 1982-10-20 | Schering Aktiengesellschaft | Neue Indol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Präparate, die diese Verbindungen enthalten |
| EP0099766A1 (fr) * | 1982-06-03 | 1984-02-01 | Roussel-Uclaf | Nouveaux dérivés de la 1,3-dihydro 4-(1-hydroxy 2-aminoéthyl) 2H-indol-2-one, leurs sels, procédé de préparation, application à titre de médicaments et compositions les renfermant |
| US4521606A (en) * | 1983-06-30 | 1985-06-04 | American Home Products Corp. | 5-Indolyl substituted aminoethanols |
| US4562200A (en) * | 1983-06-30 | 1985-12-31 | American Home Products Corporation | 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives |
| US4622399A (en) * | 1983-06-30 | 1986-11-11 | American Home Products Corporation | Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives |
| EP0177245A3 (en) * | 1984-09-28 | 1987-07-01 | Nippon Chemiphar Co., Ltd. | Amino-alcohol derivatives and processes for their preparation |
| WO1987002359A1 (en) * | 1985-10-14 | 1987-04-23 | Maggioni-Winthrop S.P.A. | Dihydrobenzothiophene and thiochromane aminoalcohols |
| US5674891A (en) * | 1994-07-27 | 1997-10-07 | The Procter & Gamble Company | Dihydrobenzothiophene compounds useful as anti-inflammatory agents |
| US5656661A (en) * | 1994-07-27 | 1997-08-12 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1996003396A1 (en) * | 1994-07-27 | 1996-02-08 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1997017324A1 (fr) * | 1995-11-10 | 1997-05-15 | Rhodia Chimie | Procede d'acylation d'un thioether aromatique |
| FR2741067A1 (fr) * | 1995-11-10 | 1997-05-16 | Rhone Poulenc Chimie | Procede d'acylation d'un thioether aromatique |
| US5672620A (en) * | 1996-02-01 | 1997-09-30 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| US5684031A (en) * | 1996-02-01 | 1997-11-04 | The Procter & Gamble Company | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
| WO1998008834A1 (fr) * | 1996-08-29 | 1998-03-05 | Synthelabo | Derives de benzylamine, leur preparation et leur application en therapeutique |
| FR2752840A1 (fr) * | 1996-08-29 | 1998-03-06 | Synthelabo | Derives de benzothiophene, leur preparation et leur application en therapeutique |
| US6060508A (en) * | 1996-08-29 | 2000-05-09 | Synthelabo | Benzylamine derivatives, their preparation and their application in therapeutics |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2370472B2 (cs) | 1982-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property |