FR2364914A1 - PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID - Google Patents

PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID

Info

Publication number
FR2364914A1
FR2364914A1 FR7628272A FR7628272A FR2364914A1 FR 2364914 A1 FR2364914 A1 FR 2364914A1 FR 7628272 A FR7628272 A FR 7628272A FR 7628272 A FR7628272 A FR 7628272A FR 2364914 A1 FR2364914 A1 FR 2364914A1
Authority
FR
France
Prior art keywords
thenoyl
dichloro
phenoxy
preparation
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7628272A
Other languages
French (fr)
Other versions
FR2364914B1 (en
Inventor
Jacqueline Suzanne Laforest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Albert Rolland SA
Original Assignee
Laboratoires Albert Rolland SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Albert Rolland SA filed Critical Laboratoires Albert Rolland SA
Priority to FR7628272A priority Critical patent/FR2364914A1/en
Priority to CA286,001A priority patent/CA1089475A/en
Priority to IL52879A priority patent/IL52879A/en
Priority to IT27347/77A priority patent/IT1086081B/en
Priority to PT67033A priority patent/PT67033B/en
Priority to PL20093677A priority patent/PL200936A1/en
Priority to GR54372A priority patent/GR63627B/en
Priority to HU77RO943A priority patent/HU173514B/en
Priority to CH1150977A priority patent/CH623048A5/en
Priority to JP11389877A priority patent/JPS5340756A/en
Priority to ES462470A priority patent/ES462470A1/en
Publication of FR2364914A1 publication Critical patent/FR2364914A1/en
Application granted granted Critical
Publication of FR2364914B1 publication Critical patent/FR2364914B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

This compound, also called tienilic acid, is a diuretic and uricosuric agent used in therapeutics. According to the invention, it is obtained in the very pure state in a single operation by decarboxylating, by heating, a compound of formula I in which R is a hydrogen atom or an alkyl group. When R is an alkyl group, the phenoxyacetic ester obtained is hydrolysed.
FR7628272A 1976-09-21 1976-09-21 PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID Granted FR2364914A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR7628272A FR2364914A1 (en) 1976-09-21 1976-09-21 PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID
CA286,001A CA1089475A (en) 1976-09-21 1977-09-01 Process for the preparation of 2,3-dichloro-4-(2-thenoyl) phenoxyacetic acid
IL52879A IL52879A (en) 1976-09-21 1977-09-02 Process for the preparation of 2,3-dichloro-4-(2-thenoyl) phenoxyacetic acid and 2,3-dichloro-4-(2-thenoyl)phenoxy malonic acid derivatives as intermediates therefor
IT27347/77A IT1086081B (en) 1976-09-21 1977-09-07 PROCEDURE FOR THE PREPARATION OF 2,3-DICHLORO-4- (2-TENOIL) PHENOXYAETHETIC ACID
PT67033A PT67033B (en) 1976-09-21 1977-09-15 Process for the preparation of 2,3-dicloro-4-(2-thenoyl) phenoxyacetic acid
GR54372A GR63627B (en) 1976-09-21 1977-09-19 Process for preparation of 2,3-dichloro-4-(2-thenoyl)phenoxy acetic acid
PL20093677A PL200936A1 (en) 1976-09-21 1977-09-19 METHOD FOR THE PRODUCTION OF 2,3-DICHLORO-4- / 2-TENOYL / -PHENOXYACIC ACID
HU77RO943A HU173514B (en) 1976-09-21 1977-09-20 Process for preparing 2,3-dichloro-4-/2-tenoyl/-phenoxy-malonic acid derivatives
CH1150977A CH623048A5 (en) 1976-09-21 1977-09-20 Process for the preparation of 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
JP11389877A JPS5340756A (en) 1976-09-21 1977-09-20 Preparation of 2*33dichloroo44 *22thenoyl*phenoxyacetic acid
ES462470A ES462470A1 (en) 1976-09-21 1977-09-20 Preparation of 2*33dichloroo44 *22thenoyl*phenoxyacetic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7628272A FR2364914A1 (en) 1976-09-21 1976-09-21 PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID

Publications (2)

Publication Number Publication Date
FR2364914A1 true FR2364914A1 (en) 1978-04-14
FR2364914B1 FR2364914B1 (en) 1980-07-25

Family

ID=9177879

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7628272A Granted FR2364914A1 (en) 1976-09-21 1976-09-21 PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXY-ACETIC ACID

Country Status (11)

Country Link
JP (1) JPS5340756A (en)
CA (1) CA1089475A (en)
CH (1) CH623048A5 (en)
ES (1) ES462470A1 (en)
FR (1) FR2364914A1 (en)
GR (1) GR63627B (en)
HU (1) HU173514B (en)
IL (1) IL52879A (en)
IT (1) IT1086081B (en)
PL (1) PL200936A1 (en)
PT (1) PT67033B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029740A1 (en) * 1979-11-27 1981-06-03 Farmos-Yhtyma Oy Process for the preparation of a therapeutically active substituted phenoxyacetic acid and a novel acid anhydride for use therein

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0632887B2 (en) * 1986-08-29 1994-05-02 株式会社日立製作所 Chamfering method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793212A1 (en) * 1967-08-31 1972-03-30 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of 2,3-dichloro-4-butyryl-phenoxyacetic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1793212A1 (en) * 1967-08-31 1972-03-30 Egyt Gyogyszervegyeszeti Gyar Process for the preparation of 2,3-dichloro-4-butyryl-phenoxyacetic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029740A1 (en) * 1979-11-27 1981-06-03 Farmos-Yhtyma Oy Process for the preparation of a therapeutically active substituted phenoxyacetic acid and a novel acid anhydride for use therein

Also Published As

Publication number Publication date
HU173514B (en) 1979-05-28
PL200936A1 (en) 1978-05-22
GR63627B (en) 1979-11-27
CH623048A5 (en) 1981-05-15
IT1086081B (en) 1985-05-28
IL52879A0 (en) 1977-11-30
JPS5340756A (en) 1978-04-13
CA1089475A (en) 1980-11-11
FR2364914B1 (en) 1980-07-25
IL52879A (en) 1981-09-13
PT67033A (en) 1977-10-01
ES462470A1 (en) 1978-07-16
PT67033B (en) 1979-02-15

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Legal Events

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