FR2364915A1 - NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID - Google Patents

NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID

Info

Publication number
FR2364915A1
FR2364915A1 FR7628273A FR7628273A FR2364915A1 FR 2364915 A1 FR2364915 A1 FR 2364915A1 FR 7628273 A FR7628273 A FR 7628273A FR 7628273 A FR7628273 A FR 7628273A FR 2364915 A1 FR2364915 A1 FR 2364915A1
Authority
FR
France
Prior art keywords
thenoyl
dichloro
preparation
new process
phenoxyacetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7628273A
Other languages
French (fr)
Other versions
FR2364915B1 (en
Inventor
Jacqueline Suzanne Laforest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Albert Rolland SA
Original Assignee
Laboratoires Albert Rolland SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Albert Rolland SA filed Critical Laboratoires Albert Rolland SA
Priority to FR7628273A priority Critical patent/FR2364915A1/en
Priority to CA286,002A priority patent/CA1083161A/en
Priority to IL52880A priority patent/IL52880A/en
Priority to IT27348/77A priority patent/IT1086082B/en
Priority to PT67034A priority patent/PT67034B/en
Priority to GR54373A priority patent/GR63644B/en
Priority to PL20093577A priority patent/PL200935A1/en
Priority to JP11389977A priority patent/JPS5340757A/en
Priority to ES462471A priority patent/ES462471A1/en
Priority to CH1151077A priority patent/CH623049A5/en
Priority to HU77RO944A priority patent/HU173515B/en
Publication of FR2364915A1 publication Critical patent/FR2364915A1/en
Application granted granted Critical
Publication of FR2364915B1 publication Critical patent/FR2364915B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This compound, also called tienilic acid, is a diuretic and uricosuric agent used in therapy. It is obtained in the very pure state in a single operation by oxidising a compound of formula I, in which Z is a -CH2OH, -CHOH-CH2OH or -CHO group, by means of an inorganic oxidising agent in a solvent at a temperature from -15 to 75 DEG C. The oxidising agent can be potassium permanganate, potassium chromate or sodium periodate.
FR7628273A 1976-09-21 1976-09-21 NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID Granted FR2364915A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR7628273A FR2364915A1 (en) 1976-09-21 1976-09-21 NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID
CA286,002A CA1083161A (en) 1976-09-21 1977-09-01 Process for the preparation of 2,3-dichloro-4-(2- thenoyl) phenoxyacetic acid
IL52880A IL52880A (en) 1976-09-21 1977-09-02 Process for the preparation of 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid and some novel intermediates therefor
IT27348/77A IT1086082B (en) 1976-09-21 1977-09-07 PERFECTED PROCEDURE FOR THE PREPARATION OF 2,3-DICHLORO-4- (2-TENOIL) PHENOXYCETIC ACID
PT67034A PT67034B (en) 1976-09-21 1977-09-15 New process for the preparation of 2,3-dichloro-4-(2-thenoyl) phenoxyacetic acid
PL20093577A PL200935A1 (en) 1976-09-21 1977-09-19 METHOD FOR THE PRODUCTION OF 2,3-DICHLORO-4- / 2-TENOYL / PHENOXYOCIC ACID
GR54373A GR63644B (en) 1976-09-21 1977-09-19 New process for preparation of 2,3-dicloro-4-(2-thenoyl)phenoxyaxetic acid
JP11389977A JPS5340757A (en) 1976-09-21 1977-09-20 Novel method of preparation of 2*33dichloroo 44*22thenoyl*phenoxyacetic acid
ES462471A ES462471A1 (en) 1976-09-21 1977-09-20 Novel method of preparation of 2*33dichloroo 44*22thenoyl*phenoxyacetic acid
CH1151077A CH623049A5 (en) 1976-09-21 1977-09-20 Process for the preparation of 2,3-dichloro-4-(2-thenoyl)phenoxyacetic acid
HU77RO944A HU173515B (en) 1976-09-21 1977-09-20 Process for preparing /2,3-dichloro-phenyl/-2-thienyl/-ketone derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7628273A FR2364915A1 (en) 1976-09-21 1976-09-21 NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID

Publications (2)

Publication Number Publication Date
FR2364915A1 true FR2364915A1 (en) 1978-04-14
FR2364915B1 FR2364915B1 (en) 1982-02-12

Family

ID=9177880

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7628273A Granted FR2364915A1 (en) 1976-09-21 1976-09-21 NEW PROCESS FOR THE PREPARATION OF DICHLORO-2,3 (THENOYL-2) -4 PHENOXYACETIC ACID

Country Status (11)

Country Link
JP (1) JPS5340757A (en)
CA (1) CA1083161A (en)
CH (1) CH623049A5 (en)
ES (1) ES462471A1 (en)
FR (1) FR2364915A1 (en)
GR (1) GR63644B (en)
HU (1) HU173515B (en)
IL (1) IL52880A (en)
IT (1) IT1086082B (en)
PL (1) PL200935A1 (en)
PT (1) PT67034B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407925A1 (en) * 1977-11-02 1979-06-01 Smithkline Corp PROCESS FOR THE PREPARATION OF 2,3 DICHLORO-4- (2-THENOYL) PHENOXYACETIC ACID

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1505328A (en) * 1964-06-04 1967-12-15 Merck & Co Inc Process for the preparation of carboxylic acids by oxidation
FR1568718A (en) * 1963-12-03 1969-05-30

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1568718A (en) * 1963-12-03 1969-05-30
FR1505328A (en) * 1964-06-04 1967-12-15 Merck & Co Inc Process for the preparation of carboxylic acids by oxidation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2407925A1 (en) * 1977-11-02 1979-06-01 Smithkline Corp PROCESS FOR THE PREPARATION OF 2,3 DICHLORO-4- (2-THENOYL) PHENOXYACETIC ACID

Also Published As

Publication number Publication date
FR2364915B1 (en) 1982-02-12
PT67034B (en) 1979-02-15
GR63644B (en) 1979-11-28
CH623049A5 (en) 1981-05-15
JPS5340757A (en) 1978-04-13
CA1083161A (en) 1980-08-05
PL200935A1 (en) 1978-05-22
ES462471A1 (en) 1978-07-16
IL52880A (en) 1981-11-30
HU173515B (en) 1979-05-28
IT1086082B (en) 1985-05-28
PT67034A (en) 1977-10-01
IL52880A0 (en) 1977-11-30

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Legal Events

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