FR2363325A2 - Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively - Google Patents

Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively

Info

Publication number
FR2363325A2
FR2363325A2 FR7626323A FR7626323A FR2363325A2 FR 2363325 A2 FR2363325 A2 FR 2363325A2 FR 7626323 A FR7626323 A FR 7626323A FR 7626323 A FR7626323 A FR 7626323A FR 2363325 A2 FR2363325 A2 FR 2363325A2
Authority
FR
France
Prior art keywords
fenspiride
pyribedil
cough
mixt
binding agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7626323A
Other languages
French (fr)
Other versions
FR2363325B2 (en
Inventor
Claude Mony
Genevieve Costes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Priority to FR7626323A priority Critical patent/FR2363325A2/en
Priority to GR54224A priority patent/GR61695B7/en
Priority to IL7752864A priority patent/IL52864A/en
Priority to BE180605A priority patent/BE858310R/en
Publication of FR2363325A2 publication Critical patent/FR2363325A2/en
Application granted granted Critical
Publication of FR2363325B2 publication Critical patent/FR2363325B2/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Abstract

Prepn. of dry, oral, prolonged-release compsns. by incorporation of fenspiride, pyribedil or their salts with on or more water-insol. inert diluents having a low compressibility index, and a cellulose ether binding agent which is insoluble in water and non-polar organic solvents, in presence of a solvent or solvent mixt. in which the binding agent is soluble, then converting the mixt. into the final dosage form. Progressive liberation of active constituents, over periods of more than five hrs. Fenspiride gives long-acting control of cough and pyribedil controls disorders of peripheral circulation. A typical coated tablet contained 80 mg. of fenspiride hydrochloride mixed with talc and ethyl cellulose which was granulated with ethanol and dried. The granules were mixed with Mg stearate, compressed and the tablet cores were coated and wax polished.
FR7626323A 1973-05-02 1976-09-01 Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively Granted FR2363325A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7626323A FR2363325A2 (en) 1976-09-01 1976-09-01 Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively
GR54224A GR61695B7 (en) 1973-05-02 1977-08-24 Process for obtaining medicinal preparations orally
IL7752864A IL52864A (en) 1973-05-09 1977-08-31 Process for producing oral pharmaceutical compositions having delayed action
BE180605A BE858310R (en) 1976-09-01 1977-08-31 PROCEDURE FOR DISCLOSURE OF DELAY PHARMACEUTICAL FORMS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7626323A FR2363325A2 (en) 1976-09-01 1976-09-01 Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively

Publications (2)

Publication Number Publication Date
FR2363325A2 true FR2363325A2 (en) 1978-03-31
FR2363325B2 FR2363325B2 (en) 1979-03-02

Family

ID=9177296

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7626323A Granted FR2363325A2 (en) 1973-05-02 1976-09-01 Delayed-release tablets - of fenspiride or pyribedil for control of cough or vascular disorders respectively

Country Status (2)

Country Link
BE (1) BE858310R (en)
FR (1) FR2363325A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054670A2 (en) * 2000-01-28 2001-08-02 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001054670A2 (en) * 2000-01-28 2001-08-02 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms
WO2001054670A3 (en) * 2000-01-28 2002-04-18 Boehringer Ingelheim Pharma Method for coating pharmaceutical dosage forms
US6503535B2 (en) 2000-01-28 2003-01-07 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms
US6753012B2 (en) 2000-01-28 2004-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. Method for coating pharmaceutical dosage forms

Also Published As

Publication number Publication date
FR2363325B2 (en) 1979-03-02
BE858310R (en) 1978-02-28

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