TW289733B - Process for preparing round pellets of Omeprazole for oral administration - Google Patents
Process for preparing round pellets of Omeprazole for oral administrationInfo
- Publication number
- TW289733B TW289733B TW84104486A TW84104486A TW289733B TW 289733 B TW289733 B TW 289733B TW 84104486 A TW84104486 A TW 84104486A TW 84104486 A TW84104486 A TW 84104486A TW 289733 B TW289733 B TW 289733B
- Authority
- TW
- Taiwan
- Prior art keywords
- omeprazole
- solution
- ammonia
- binder
- ethanol
- Prior art date
Links
Abstract
A process for preparing round pellets for oral administration containing Omeprazole, which process includes: (1) dissolving Omeprazole and a part of a excipient in a solution comprising ethanol, water, ammonia and binder; (2) preparing a core from white sugar, starch or microcrystalline cellulose, spraying the solution of step (1) onto the core, and adding granulating materials followed by granulating and drying; (3) conducting a sub-coating treatment by dissolving a part of the excipient to a solution comprising ethanol, water, ammonia and binder, spraying the solution to the medicine-containing granules of step (2), mixing evenly with a granulating materials followed by drying; (4) intestinal-coating the granules coated with a sub-coating layer in step (3); characterized by that the ethanol to water ratio in steps (1) and (3) is 70-80:30-20 wt.% and ammonia 0.5-10 wt.% and binder 2-10 wt.% are added.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW84104486A TW289733B (en) | 1995-05-05 | 1995-05-05 | Process for preparing round pellets of Omeprazole for oral administration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW84104486A TW289733B (en) | 1995-05-05 | 1995-05-05 | Process for preparing round pellets of Omeprazole for oral administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW289733B true TW289733B (en) | 1996-11-01 |
Family
ID=51398180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW84104486A TW289733B (en) | 1995-05-05 | 1995-05-05 | Process for preparing round pellets of Omeprazole for oral administration |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW289733B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
| WO2006066932A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution |
-
1995
- 1995-05-05 TW TW84104486A patent/TW289733B/en active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5997905A (en) * | 1998-09-04 | 1999-12-07 | Mcneil-Ppc | Preparation of pharmaceutically active particles |
| US6149943A (en) * | 1998-09-04 | 2000-11-21 | Mcneil-Ppc, Inc. | Microcrystalline cellulose particles having active core |
| WO2006066932A1 (en) * | 2004-12-24 | 2006-06-29 | Lek Pharmaceuticals D.D. | Stable pharmaceutical composition comprising an active substance in the form of solid solution |
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