FR2359125A1 - NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM - Google Patents

NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Info

Publication number
FR2359125A1
FR2359125A1 FR7703076A FR7703076A FR2359125A1 FR 2359125 A1 FR2359125 A1 FR 2359125A1 FR 7703076 A FR7703076 A FR 7703076A FR 7703076 A FR7703076 A FR 7703076A FR 2359125 A1 FR2359125 A1 FR 2359125A1
Authority
FR
France
Prior art keywords
preparation process
product containing
medicinal product
prostaglandin derivatives
new prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7703076A
Other languages
French (fr)
Other versions
FR2359125B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2359125A1 publication Critical patent/FR2359125A1/en
Application granted granted Critical
Publication of FR2359125B1 publication Critical patent/FR2359125B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)

Abstract

L'invention concerne de nouveaux dérivés de prostaglandine (PG1 ) à fonction 9-déoxy-6,9-époxy ainsi que 5-iodo. Les nouveaux dérives de l'Invention sont doués d'activité pharmacologique.The invention relates to novel 9-deoxy-6,9-epoxy-functional prostaglandin (PG1) derivatives as well as 5-iodo. The new drifts of the invention are endowed with pharmacological activity.

FR7703076A 1976-02-04 1977-02-03 NOVEL PROSTAGLANDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Expired FR2359125B1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65511076A 1976-02-04 1976-02-04
US71696976A 1976-08-23 1976-08-23
US71677176A 1976-08-23 1976-08-23
US71696076A 1976-08-23 1976-08-23
US71697276A 1976-08-23 1976-08-23
US71677076A 1976-08-23 1976-08-23
US72554876A 1976-09-22 1976-09-22

Publications (2)

Publication Number Publication Date
FR2359125A1 true FR2359125A1 (en) 1978-02-17
FR2359125B1 FR2359125B1 (en) 1985-11-15

Family

ID=27569874

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7703076A Expired FR2359125B1 (en) 1976-02-04 1977-02-03 NOVEL PROSTAGLANDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM
FR7732282A Granted FR2362833A1 (en) 1976-02-04 1977-10-26 NEW PROSTAGLANDIN 5 DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR7732283A Granted FR2362834A1 (en) 1976-02-04 1977-10-26 NEW 6-HEMICETAL OR 6-CETO DERIVATIVES OF PROSTAGLANDIN, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7732282A Granted FR2362833A1 (en) 1976-02-04 1977-10-26 NEW PROSTAGLANDIN 5 DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR7732283A Granted FR2362834A1 (en) 1976-02-04 1977-10-26 NEW 6-HEMICETAL OR 6-CETO DERIVATIVES OF PROSTAGLANDIN, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Country Status (13)

Country Link
JP (1) JPS5936911B2 (en)
BE (1) BE851122A (en)
CA (3) CA1160627A (en)
CH (2) CH632245A5 (en)
DE (1) DE2702553C2 (en)
FR (3) FR2359125B1 (en)
GB (1) GB1554044A (en)
HK (1) HK9385A (en)
IL (1) IL51189A (en)
MX (1) MX4811E (en)
NL (2) NL185515C (en)
NZ (1) NZ183050A (en)
SE (1) SE435281B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401141A1 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW HALOGEN DERIVATIVES OF PROSTAGLANDINS AND MEDICINES CONTAINING THEM

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
IT1079025B (en) * 1976-05-11 1985-05-08 Wellcome Found IMPROVEMENT IN THE PREPARATION OF ETERI
GB1595056A (en) * 1976-10-12 1981-08-05 Wellcome Found Pharmaceutical combination
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues
FI71138C (en) * 1976-12-31 1986-11-24 Erba Farmitalia FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds
JPS6022710B2 (en) * 1977-09-16 1985-06-03 小野薬品工業株式会社 Prostaglandin-like compounds
DE2743283A1 (en) * 1977-09-27 1979-04-05 Hoechst Ag NEW PROSTACYCLIN ANALOG
IT1088036B (en) 1977-11-25 1985-06-04 Erba Carlo Spa 15-EPI-PROSTACYCLINE AND ANALOG PROSTACYCLINE
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
IT1099575B (en) * 1978-07-20 1985-09-18 Erba Carlo Spa 20-METHYL-13,14-DEHYDRO-PGI2 'ITS SALTS AND ITS 16S- AND 16R-METHYL DERIVATIVES
DE2834248A1 (en) * 1978-08-04 1980-02-28 Hoechst Ag NEW PROSTAGLAND DERIVATIVES IN THE DELTA 2-PGF TIEF 2 AND DELTA 2-PGE TIEF 2 SERIES
US4180657A (en) * 1978-08-14 1979-12-25 The Upjohn Company Acyl-substituted phenyl esters of prostacyclin-type compounds
JPS56122372A (en) * 1980-03-03 1981-09-25 Toray Ind Inc Prostaglandin i2 derivative
DE3029984C2 (en) * 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octane derivatives and medicinal products containing them
CH648556A5 (en) * 1981-03-11 1985-03-29 Hoffmann La Roche FLUORPROSTACYCLINE.
JPS595155A (en) * 1982-06-30 1984-01-12 Ono Pharmaceut Co Ltd Prostaglandin d-mimic compound, its preparation and antitumor agent containing the same
CA1324129C (en) * 1987-04-30 1993-11-09 Ryuzo Ueno Prostaglandins of the f series
US5221763A (en) * 1987-04-30 1993-06-22 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5591887A (en) * 1987-04-30 1997-01-07 R-Tech Ueno, Ltd. Prostaglandins of the F series
US5185374A (en) * 1988-05-11 1993-02-09 K.K. Ueno Seiyaku Oyo Kenkyujo Use of 15-ketoprostaglandin E or F compounds for uterine contraction
AU619543B2 (en) * 1988-05-11 1992-01-30 Sucampo Ag Use of 15-ketoprostaglandin e or f compounds for uterine contraction
JP5652397B2 (en) 2009-07-28 2015-01-14 小野薬品工業株式会社 Bicyclic compounds and their pharmaceutical uses
JP5835236B2 (en) 2011-01-27 2015-12-24 小野薬品工業株式会社 Bicyclic compounds and their pharmaceutical uses
CN116143742A (en) * 2023-02-27 2023-05-23 广州楷石生物科技有限公司 Epoprostenol nitric oxide donor drugs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (en) * 1975-10-21 1977-12-09 Wellcome Found Prostaglandin derivs.
FR2351113A1 (en) * 1976-05-11 1977-12-09 Wellcome Found PROSTAGLANDIN DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
FR2353543A1 (en) * 1976-06-01 1977-12-30 Upjohn Co ANALOGUES OF 5,6-DIHYDRO-PROSTACYCLINE AND THEIR PREPARATION

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU511711B2 (en) * 1976-12-30 1980-09-04 Upjohn Company, The 6-Oxo and 5, 6-Dihalo prostaglandin analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351112A1 (en) * 1975-10-21 1977-12-09 Wellcome Found Prostaglandin derivs.
FR2351113A1 (en) * 1976-05-11 1977-12-09 Wellcome Found PROSTAGLANDIN DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES
FR2353543A1 (en) * 1976-06-01 1977-12-30 Upjohn Co ANALOGUES OF 5,6-DIHYDRO-PROSTACYCLINE AND THEIR PREPARATION

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401141A1 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW HALOGEN DERIVATIVES OF PROSTAGLANDINS AND MEDICINES CONTAINING THEM
FR2401139A2 (en) * 1977-03-07 1979-03-23 Upjohn Co NEW D5 DERIVATIVES OF PROSTAGLANDINS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
IL51189A (en) 1985-08-30
CA1160627A (en) 1984-01-17
NL7700896A (en) 1977-08-08
SE7701045L (en) 1977-08-05
NL185515C (en) 1990-05-01
NZ183050A (en) 1979-06-08
DE2702553C2 (en) 1986-02-20
GB1554044A (en) 1979-10-17
FR2362833B1 (en) 1980-08-08
FR2362833A1 (en) 1978-03-24
CA1160628A (en) 1984-01-17
FR2359125B1 (en) 1985-11-15
FR2362834A1 (en) 1978-03-24
SE435281B (en) 1984-09-17
NL8300921A (en) 1983-07-01
JPS5936911B2 (en) 1984-09-06
IL51189A0 (en) 1977-02-28
HK9385A (en) 1985-02-08
CH632245A5 (en) 1982-09-30
JPS5295644A (en) 1977-08-11
MX4811E (en) 1982-10-19
NL185515B (en) 1989-12-01
DE2702553A1 (en) 1977-08-18
BE851122A (en) 1977-08-04
CA1179335A (en) 1984-12-11
FR2362834B1 (en) 1980-08-08
CH637949A5 (en) 1983-08-31

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Legal Events

Date Code Title Description
ST Notification of lapse