FR2351112A1 - Prostaglandin derivs. - Google Patents
Prostaglandin derivs.Info
- Publication number
- FR2351112A1 FR2351112A1 FR7714201A FR7714201A FR2351112A1 FR 2351112 A1 FR2351112 A1 FR 2351112A1 FR 7714201 A FR7714201 A FR 7714201A FR 7714201 A FR7714201 A FR 7714201A FR 2351112 A1 FR2351112 A1 FR 2351112A1
- Authority
- FR
- France
- Prior art keywords
- cpds
- healing
- alpha
- derivs
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(5Z)-5,6-Didehydro-9-deoxy-6,9 alpha-epoxyprostaglandin F1 alpha derivs. of formula (I) are novel cpds. In (I) R=H or a pharmacologically acceptable cation (esp. Na) and Z1, Z2=H or a blocking radical e.g. acyl or trialkylsilyl.(I) (R, Z1Z2=H) (known as prostacycline), and its salts is a useful intermediate for the synthesis of cpds. analogous to prostaglandins and has a strong antiaggreation effect on blood platelets, and is used in the prophylaxis and treatment of thromboses. Protacycline also inhibits and controls excessive gastric, secretion (avoiding or attenuating gastro-intestinal ulcers and lesions and accelerating their healing), is a vasodilator used particularly as an antihypertensive and favours the healing of wounds.The cpds. are usually administered parenterally (intravenously, sub-cutaneously or intramuscularly) in doses of 0.01-200 mg/kg, pref.0.01-10 mg/kg
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/624,486 US3984400A (en) | 1975-10-21 | 1975-10-21 | 11-Desoxy-16-aryl-ω-tetranorprostaglandins |
FR7631769A FR2361871A1 (en) | 1975-10-21 | 1976-10-21 | Antihypertensive, antiulcer prostaglandins |
FR7710593A FR2351111A1 (en) | 1976-05-11 | 1977-04-07 | 2- (2B-ETHYNYL-CYCLOPENT-1A-YL) ACETALDEHYDES METHYLACETALS AND THEIR PREPARATION |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2351112A1 true FR2351112A1 (en) | 1977-12-09 |
FR2351112B1 FR2351112B1 (en) | 1981-05-29 |
Family
ID=27250686
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7714201A Granted FR2351112A1 (en) | 1975-10-21 | 1977-05-10 | Prostaglandin derivs. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2351112A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2359125A1 (en) * | 1976-02-04 | 1978-02-17 | Upjohn Co | NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
FR2378777A1 (en) * | 1977-01-31 | 1978-08-25 | Ono Pharmaceutical Co | NEW ANALOGUES OF PROSTAGLANDINS |
FR2401139A2 (en) * | 1977-03-07 | 1979-03-23 | Upjohn Co | NEW D5 DERIVATIVES OF PROSTAGLANDINS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM |
FR2401920A1 (en) * | 1977-07-28 | 1979-03-30 | Upjohn Co | PROSTAGLANDINE DERIVATIVES |
EP0001270A1 (en) * | 1977-09-27 | 1979-04-04 | Hoechst Aktiengesellschaft | Analogues of prostacycline, methods for their preparation and their use in the treatment of circulatory diseases |
EP0005768A1 (en) * | 1978-05-17 | 1979-12-12 | The Wellcome Foundation Limited | Pharmaceutical formulations containing prostaglandin compounds and method for their preparation |
EP0013955A1 (en) * | 1979-01-25 | 1980-08-06 | Hoechst Aktiengesellschaft | Analogues of prostacyclin, their intermediates, a process for their preparation and medicaments containing them |
EP0052204A1 (en) * | 1980-11-13 | 1982-05-26 | American Cyanamid Company | Prostacyclin analogs of the 1 series and related analogs |
FR2513639A1 (en) * | 1981-09-25 | 1983-04-01 | Squibb & Sons Inc | NOVEL DIOXATRICYCLIC PROSTACYCLINS USEFUL AS CARDIOVASCULAR MEDICAMENTS AND NEW PRODUCTS USEFUL AS INTERMEDIATES FOR THEIR SYNTHESIS |
EP0084775A1 (en) * | 1982-01-21 | 1983-08-03 | MERCK PATENT GmbH | 13-Thia-prostacyclines |
WO2013024051A1 (en) * | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
-
1977
- 1977-05-10 FR FR7714201A patent/FR2351112A1/en active Granted
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2359125A1 (en) * | 1976-02-04 | 1978-02-17 | Upjohn Co | NEW PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
FR2362833A1 (en) * | 1976-02-04 | 1978-03-24 | Upjohn Co | NEW PROSTAGLANDIN 5 DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM |
FR2378777A1 (en) * | 1977-01-31 | 1978-08-25 | Ono Pharmaceutical Co | NEW ANALOGUES OF PROSTAGLANDINS |
FR2401139A2 (en) * | 1977-03-07 | 1979-03-23 | Upjohn Co | NEW D5 DERIVATIVES OF PROSTAGLANDINS, THEIR PREPARATION PROCESS AND MEDICINAL PRODUCTS CONTAINING THEM |
FR2401141A1 (en) * | 1977-03-07 | 1979-03-23 | Upjohn Co | NEW HALOGEN DERIVATIVES OF PROSTAGLANDINS AND MEDICINES CONTAINING THEM |
FR2401920A1 (en) * | 1977-07-28 | 1979-03-30 | Upjohn Co | PROSTAGLANDINE DERIVATIVES |
FR2401921A1 (en) * | 1977-07-28 | 1979-03-30 | Upjohn Co | PROSTAGLANDINE DERIVATIVES |
EP0001270A1 (en) * | 1977-09-27 | 1979-04-04 | Hoechst Aktiengesellschaft | Analogues of prostacycline, methods for their preparation and their use in the treatment of circulatory diseases |
EP0005768A1 (en) * | 1978-05-17 | 1979-12-12 | The Wellcome Foundation Limited | Pharmaceutical formulations containing prostaglandin compounds and method for their preparation |
FR2425856A1 (en) * | 1978-05-17 | 1979-12-14 | Wellcome Found | PROSTAGLANDIN MEDICINAL PRODUCT |
EP0013955A1 (en) * | 1979-01-25 | 1980-08-06 | Hoechst Aktiengesellschaft | Analogues of prostacyclin, their intermediates, a process for their preparation and medicaments containing them |
EP0052204A1 (en) * | 1980-11-13 | 1982-05-26 | American Cyanamid Company | Prostacyclin analogs of the 1 series and related analogs |
FR2513639A1 (en) * | 1981-09-25 | 1983-04-01 | Squibb & Sons Inc | NOVEL DIOXATRICYCLIC PROSTACYCLINS USEFUL AS CARDIOVASCULAR MEDICAMENTS AND NEW PRODUCTS USEFUL AS INTERMEDIATES FOR THEIR SYNTHESIS |
EP0084775A1 (en) * | 1982-01-21 | 1983-08-03 | MERCK PATENT GmbH | 13-Thia-prostacyclines |
WO2013024051A1 (en) * | 2011-08-12 | 2013-02-21 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
US9872864B2 (en) | 2011-08-12 | 2018-01-23 | Ascendis Pharma A/S | Sustained release composition of prostacyclin |
Also Published As
Publication number | Publication date |
---|---|
FR2351112B1 (en) | 1981-05-29 |
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