FR2354770A1 - Nouveaux derives de la nitro-10 oxo-7 7h-indolizino(7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent - Google Patents
Nouveaux derives de la nitro-10 oxo-7 7h-indolizino(7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennentInfo
- Publication number
- FR2354770A1 FR2354770A1 FR7618232A FR7618232A FR2354770A1 FR 2354770 A1 FR2354770 A1 FR 2354770A1 FR 7618232 A FR7618232 A FR 7618232A FR 7618232 A FR7618232 A FR 7618232A FR 2354770 A1 FR2354770 A1 FR 2354770A1
- Authority
- FR
- France
- Prior art keywords
- indolizino
- opt
- substd
- isoquinoline
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002421 anti-septic effect Effects 0.000 title abstract 2
- 229940121375 antifungal agent Drugs 0.000 title abstract 2
- 229940064004 antiseptic throat preparations Drugs 0.000 title abstract 2
- QAPSDKBLOGERDH-UHFFFAOYSA-N indolizino[1,2-h]isoquinoline Chemical compound C1=NC=CC=2C=CC=3C(C1=2)=CN1C=CC=CC1=3 QAPSDKBLOGERDH-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 230000000845 anti-microbial effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- YKYIFUROKBDHCY-ONEGZZNKSA-N (e)-4-ethoxy-1,1,1-trifluorobut-3-en-2-one Chemical group CCO\C=C\C(=O)C(F)(F)F YKYIFUROKBDHCY-ONEGZZNKSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 231100000460 acute oral toxicity Toxicity 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7618232A FR2354770A1 (fr) | 1976-06-16 | 1976-06-16 | Nouveaux derives de la nitro-10 oxo-7 7h-indolizino(7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent |
| FR7710763A FR2386543A2 (fr) | 1976-06-16 | 1977-04-08 | Nouveaux derives de la nitro-10 oxo-7 7h-indolizino (7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent |
| NL7706309A NL7706309A (nl) | 1976-06-16 | 1977-06-08 | Werkwijze voor het bereiden van 10-nitro-7- -oxo-7h-indolizino-(7,6,5-de) isochinoline, werkwijze voor het bereiden van een farmaceu- tisch preparaat met toepassing daarvan alsmede zo gevormd preparaat. |
| ZA00773568A ZA773568B (en) | 1976-06-16 | 1977-06-14 | New derivatives of 10-nitro-7-oxo-7h-indolizino(7,6,5-de)isoquinoline |
| GB24850/77A GB1521949A (en) | 1976-06-16 | 1977-06-14 | Derivatives of 10-nitro-7-oxo-7h-indolizino(7,6,5-de)isoquinoline |
| US05/806,344 US4137315A (en) | 1976-06-16 | 1977-06-14 | Derivatives of 10-nitro-7-oxo-7H-indolizino[7,6,5-de]isoquinoline |
| IE1208/77A IE45091B1 (en) | 1976-06-16 | 1977-06-14 | New derivatives of 10-nitro-7-oxo-7h-indolizino (7,6,5-de) isoquinoline |
| AU26072/77A AU2607277A (en) | 1976-06-16 | 1977-06-14 | New derivatives of 10-nitro-7-oxo-7-h-indolizino(7,6,5-de) isoquinoline |
| IL52317A IL52317A0 (en) | 1976-06-16 | 1977-06-14 | New derivatives of 10-nitro-7-oxo-7h-indolizino(7,6,5-de)isoquinoline processes for the preparation thereof and medicinal compositions containing the same |
| JP7041777A JPS537700A (en) | 1976-06-16 | 1977-06-14 | Novel 100nitroo77oxoo7 hh indolino *7*6*55d e* isoquinoline derivative |
| PT66674A PT66674B (fr) | 1976-06-16 | 1977-06-15 | Nouveaux derives de la nitro-10 oxo-7 7h-indolizino /7,6,5-de/ isoquinoleine leur preparation et les compositions qui les contiennent |
| DK265077A DK265077A (da) | 1976-06-16 | 1977-06-15 | Fremgangsmade til fremstilling af hidtil ukendte derivater af af 10-nitro-7-oxo-7h-indolizino (7,6,5-de)isoquinolin |
| LU77541A LU77541A1 (enExample) | 1976-06-16 | 1977-06-15 | |
| SE7706946A SE7706946L (sv) | 1976-06-16 | 1977-06-15 | Forfarande for framstellning av ny derivat av 10-nitro-7-oxo-7h-indolizino (7,6,5- de) isokinolin |
| BE178462A BE855710A (fr) | 1976-06-16 | 1977-06-15 | Nouveaux derives de la nitro-10 oxo-7h-indolizino (7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent |
| DE19772727133 DE2727133A1 (de) | 1976-06-16 | 1977-06-16 | Neue derivate des 10-nitro-7-oxo- 7h-indolizino- eckige klammer auf 7,6,5- de eckige klammer zu -isochinolins, deren herstellung und diese enthaltende zusammensetzungen |
| ES459834A ES459834A1 (es) | 1976-06-16 | 1977-06-16 | Procedimiento para la preparacion de derivados de la nitro- 10 oxo-7 7h-indolizino (7,6,5-de)isoquinoleina. |
| ES462933A ES462933A1 (es) | 1976-06-16 | 1977-10-05 | Procedimiento para la preparacion de derivados de la nitro- 10-oxo-7 7h-indolizino (7,6,5-de)isoquinoleina. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7618232A FR2354770A1 (fr) | 1976-06-16 | 1976-06-16 | Nouveaux derives de la nitro-10 oxo-7 7h-indolizino(7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2354770A1 true FR2354770A1 (fr) | 1978-01-13 |
| FR2354770B1 FR2354770B1 (enExample) | 1979-03-23 |
Family
ID=9174456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7618232A Granted FR2354770A1 (fr) | 1976-06-16 | 1976-06-16 | Nouveaux derives de la nitro-10 oxo-7 7h-indolizino(7,6,5-de) isoquinoleine, leur preparation et les compositions qui les contiennent |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS537700A (enExample) |
| ES (1) | ES462933A1 (enExample) |
| FR (1) | FR2354770A1 (enExample) |
| ZA (1) | ZA773568B (enExample) |
-
1976
- 1976-06-16 FR FR7618232A patent/FR2354770A1/fr active Granted
-
1977
- 1977-06-14 JP JP7041777A patent/JPS537700A/ja active Pending
- 1977-06-14 ZA ZA00773568A patent/ZA773568B/xx unknown
- 1977-10-05 ES ES462933A patent/ES462933A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2354770B1 (enExample) | 1979-03-23 |
| ES462933A1 (es) | 1978-06-01 |
| ZA773568B (en) | 1978-05-30 |
| JPS537700A (en) | 1978-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |