FR2353530A1 - Nouveaux derives de guanidine, leur procede de preparation et composition pharmaceutique les contenant - Google Patents

Nouveaux derives de guanidine, leur procede de preparation et composition pharmaceutique les contenant

Info

Publication number
FR2353530A1
FR2353530A1 FR7717042A FR7717042A FR2353530A1 FR 2353530 A1 FR2353530 A1 FR 2353530A1 FR 7717042 A FR7717042 A FR 7717042A FR 7717042 A FR7717042 A FR 7717042A FR 2353530 A1 FR2353530 A1 FR 2353530A1
Authority
FR
France
Prior art keywords
pharmaceutical composition
composition containing
preparation process
guanidine derivatives
new guanidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7717042A
Other languages
English (en)
French (fr)
Other versions
FR2353530B1 (OSRAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB23331/76A external-priority patent/GB1530675A/en
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Publication of FR2353530A1 publication Critical patent/FR2353530A1/fr
Application granted granted Critical
Publication of FR2353530B1 publication Critical patent/FR2353530B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C07D207/327—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
FR7717042A 1976-06-05 1977-06-03 Nouveaux derives de guanidine, leur procede de preparation et composition pharmaceutique les contenant Granted FR2353530A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB23331/76A GB1530675A (en) 1976-06-05 1976-06-05 Guanidine derivatives
GB305677 1977-01-26

Publications (2)

Publication Number Publication Date
FR2353530A1 true FR2353530A1 (fr) 1977-12-30
FR2353530B1 FR2353530B1 (OSRAM) 1981-07-17

Family

ID=26237989

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7717042A Granted FR2353530A1 (fr) 1976-06-05 1977-06-03 Nouveaux derives de guanidine, leur procede de preparation et composition pharmaceutique les contenant

Country Status (15)

Country Link
US (1) US4140793A (OSRAM)
JP (1) JPS52151161A (OSRAM)
AU (1) AU509883B2 (OSRAM)
CA (1) CA1070691A (OSRAM)
CH (1) CH641159A5 (OSRAM)
CY (1) CY1130A (OSRAM)
DE (1) DE2724989A1 (OSRAM)
DK (1) DK248177A (OSRAM)
FR (1) FR2353530A1 (OSRAM)
HK (1) HK57981A (OSRAM)
IE (1) IE45198B1 (OSRAM)
KE (1) KE3170A (OSRAM)
MY (1) MY8200180A (OSRAM)
NL (1) NL7706173A (OSRAM)
SE (1) SE424861B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048190A1 (fr) * 1980-09-09 1982-03-24 Thomson-Csf Antenne réseau non dispersive, et son application à la réalisation d'une antenne à balayage électronique

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1580559A (en) * 1977-11-24 1980-12-03 Wyeth John & Brother Ltd Amide cerivatives
GB1588096A (en) * 1978-05-20 1981-04-15 Wyeth & Bros Ltd John Pyrrole derivatives
US4332822A (en) * 1980-02-05 1982-06-01 John Wyeth & Brother Limited Guanidine derivatives
US4563475A (en) * 1984-01-13 1986-01-07 William H. Rorer, Inc. Guanidine derivatives for treating gastrointestinal motility dysfunction
JPH01106831U (OSRAM) * 1988-01-08 1989-07-19
RU2006142552A (ru) * 2004-06-16 2008-07-27 Вайет (Us) Производные амино-5,5-дифенилимидазолона как ингибиторы b-секретазы
PE20060299A1 (es) * 2004-06-16 2006-05-18 Wyeth Corp DIFENILIMIDAZOPIRIMIDINA E -IMIDAZOL AMINAS COMO INHIBIDORES DE ß-SECRETASA
CA2593515A1 (en) * 2005-01-14 2006-07-20 Wyeth Amino-imidazolones for the inhibition of beta-secretase
AU2006211159A1 (en) * 2005-02-01 2006-08-10 Wyeth Amino-pyridines as inhibitors of beta-secretase
JP2008530103A (ja) * 2005-02-14 2008-08-07 ワイス β−セクレターゼ阻害剤としてのアゾリルアシルグアニジン
TW200738683A (en) * 2005-06-30 2007-10-16 Wyeth Corp Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
WO2007005404A1 (en) * 2005-06-30 2007-01-11 Wyeth AMINO-5-(6-MEMBERED)HETEROARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR ß-SECRETASE MODULATION
TW200730523A (en) * 2005-07-29 2007-08-16 Wyeth Corp Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
CA2623245A1 (en) * 2005-09-26 2007-04-05 Wyeth Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace)
BRPI0620025A2 (pt) * 2005-12-19 2011-10-25 Wyeth Corp composto, método para o tratamento de uma doença ou transtorno associado a atividade excessiva de bace, método para modular a atividade de bace, composição farmacêutica e uso do composto
WO2007100536A1 (en) * 2006-02-24 2007-09-07 Wyeth DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) * 2006-08-17 2010-04-20 Wyeth Llc Imidazole amines as inhibitors of β-secretase
MX2009003102A (es) * 2006-09-21 2009-04-01 Wyeth Corp INDOLILALQUILPIRIDIN-2-AMINAS PARA LA INHIBICION DE ß-SECRETASA.
PE20090160A1 (es) * 2007-03-20 2009-02-11 Wyeth Corp COMPUESTOS AMINO-5-[4-(DIFLUOROMETOXI)FENIL SUSTITUIDO]-5-FENILIMIDAZOLONA COMO INHIBIDORES DE ß-SECRETASA
AR065814A1 (es) 2007-03-23 2009-07-01 Wyeth Corp Derivados de 5-fenilimidazolona,inhibidores de beta-secretasa,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar trastornos asociados a niveles beta-amiloides elevados.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3189601A (en) * 1964-01-10 1965-06-15 Ciba Geigy Corp N, n-alkylene-imino-lower alkanoamidine compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048190A1 (fr) * 1980-09-09 1982-03-24 Thomson-Csf Antenne réseau non dispersive, et son application à la réalisation d'une antenne à balayage électronique

Also Published As

Publication number Publication date
CY1130A (en) 1982-02-19
IE45198B1 (en) 1982-07-14
AU509883B2 (en) 1980-05-29
KE3170A (en) 1981-12-18
NL7706173A (nl) 1977-12-07
SE7706520L (sv) 1978-01-20
JPS613332B2 (OSRAM) 1986-01-31
FR2353530B1 (OSRAM) 1981-07-17
DK248177A (da) 1977-12-06
IE45198L (en) 1977-12-05
CH641159A5 (de) 1984-02-15
CA1070691A (en) 1980-01-29
AU2535677A (en) 1978-11-23
DE2724989A1 (de) 1977-12-15
US4140793A (en) 1979-02-20
HK57981A (en) 1981-12-04
SE424861B (sv) 1982-08-16
JPS52151161A (en) 1977-12-15
MY8200180A (en) 1982-12-31

Similar Documents

Publication Publication Date Title
FR2353530A1 (fr) Nouveaux derives de guanidine, leur procede de preparation et composition pharmaceutique les contenant
BE860726A (fr) Nouveaux aryl-acylamides n-(2-aminocy-cloaliphatiques), leur procede de preparation et medicament les contenant
FR2359125B1 (fr) Nouveaux derives de prostaglandine, leur procede de preparation et medicament les contenant
BE842310A (fr) Derives de la thieno-pyridine, leur procede de preparation et composition therapeutique les contenant
BE868173A (fr) Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant
FR2346350A1 (fr) Nouveaux derives de piperazine et de piperidine, leur procede de preparation et les compositions pharmaceutiques les contenant
BE871769A (fr) Derives de quinazoline, leur procede de production et composition pharmaceutique les contenant
BE861964A (fr) Derives de la 1,4-dihydropyridine, leur procede d'obtention et composition pharmaceutique les contenant
FR2333506A1 (fr) Nouveaux derives imidazoliques, leur procede de preparation et composition pharmaceutique les contenant
BE871770A (fr) Nouveaux derives de phtalazine, leur procede de production et composition pharmaceutique les contenant
FR2338938A1 (fr) Nouveaux derives de la piperazine et de ses homologues, leur procede de preparation et medicament les contenant
FR2333496A2 (fr) Nouveaux derives d'ethanolamine, leur procede de preparation et composition pharmaceutique les contenant
FR2286643A1 (fr) Nouveaux triiodocarbanilates, leur procede de preparation et composition pharmaceutique les contenant
FR2303559A1 (fr) Nouveaux derives d'histidine, leur procede de preparation et composition pharmaceutique les contenant
BE837698A (fr) Nouveaux derives de 4-aminoquinoleine, leur procede de preparation et composition pharmaceutique les contenant
BE884620A (fr) Nouveaux derives d'halovincamone, leur procede de preparation et medicaments les contenant
BE884083A (fr) Nouveaux oxime-ethers, leur procede de preparation et compositions pharmaceutiques les contenant
FR2317930A1 (fr) Nouveaux derives d'apovincaminol, leur procede de preparation et leur application
BE858781A (fr) Nouveaux derives 1,4-dihydropyridiques de sucres, leur procede de preparation et medicament les contenant
BE835295A (fr) Nouveaux derives de cephalosporine, leur procede de preparation et composition pharmaceutique les contenant
FR2313927A1 (fr) Nouveaux derives pyrazoliques substitues en position 4, leur procede de preparation et composition pharmaceutique les contenant
BE875091A (fr) Derives de substitution de spirooxazolidinone steroidienne, leur procede de preparation et compositions pharmaceutiques les contenant
BE882535A (fr) Nouveaux derives de la phenothiazine et leur procede de preparation, et medicaments contenant lesdits derives
LU79600A1 (fr) Nouveaux derives de phenylglycine,leur procede de preparation et composition pharmaceutique les contenant
BE882675A (fr) Nouveaux derives de la benzo-as-triazine, leur procede de preparation et medicaments les contenant

Legal Events

Date Code Title Description
ST Notification of lapse