FR2352811A1 - (2,3)-Epoxy-propoxy-phenyl-acrylic acid and acrylonitrile derivs. - intermediates for cardiac-active aryloxy-propanolamines - Google Patents

(2,3)-Epoxy-propoxy-phenyl-acrylic acid and acrylonitrile derivs. - intermediates for cardiac-active aryloxy-propanolamines

Info

Publication number
FR2352811A1
FR2352811A1 FR7715887A FR7715887A FR2352811A1 FR 2352811 A1 FR2352811 A1 FR 2352811A1 FR 7715887 A FR7715887 A FR 7715887A FR 7715887 A FR7715887 A FR 7715887A FR 2352811 A1 FR2352811 A1 FR 2352811A1
Authority
FR
France
Prior art keywords
derivs
intermediates
epoxy
phenyl
cardiac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7715887A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2352811A1 publication Critical patent/FR2352811A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New 1-phenoxy-2,3-epoxy-propane derivs. are of formula (I) (where R1, R1' are each H, 1-4c alkyl, 1-4C alkoxy, allyl, halo or nitro, and R2 is -CR3= CR4-COOR5 or -CR3=CR4-CN; R3 is H, 1-5C alkyl, aryl or aralkyl opt. substd. by lower alkyl or alkoxy gps.; R4 is H or 1-8C alkyl and R5 is H alkyl or aryl-lower alkyl). (I) are intermediates for 1-aryloxy-2-hydroxy-3-aminopropanes used for the treatment of cardiac disorders. Typical (I) is dl-3-(2-(2,3-oxidopropoxy)-phenyl)-crotononitrile.
FR7715887A 1976-05-25 1977-05-25 (2,3)-Epoxy-propoxy-phenyl-acrylic acid and acrylonitrile derivs. - intermediates for cardiac-active aryloxy-propanolamines Withdrawn FR2352811A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762623313 DE2623313A1 (en) 1976-05-25 1976-05-25 NEW 1-ARYLOXY-2,3-EPOXY-PROPANE AND THE METHOD OF MANUFACTURING IT

Publications (1)

Publication Number Publication Date
FR2352811A1 true FR2352811A1 (en) 1977-12-23

Family

ID=5978906

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7715887A Withdrawn FR2352811A1 (en) 1976-05-25 1977-05-25 (2,3)-Epoxy-propoxy-phenyl-acrylic acid and acrylonitrile derivs. - intermediates for cardiac-active aryloxy-propanolamines

Country Status (17)

Country Link
JP (1) JPS5312838A (en)
AT (1) AT356125B (en)
AU (1) AU2543577A (en)
BE (1) BE855040A (en)
CA (1) CA1105041A (en)
DE (1) DE2623313A1 (en)
DK (1) DK227077A (en)
ES (1) ES458958A1 (en)
FI (1) FI771631A (en)
FR (1) FR2352811A1 (en)
HU (1) HU177844B (en)
IL (1) IL52149A0 (en)
IT (1) IT1077192B (en)
LU (1) LU77390A1 (en)
NL (1) NL7705581A (en)
SE (1) SE7706060L (en)
ZA (1) ZA773119B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146130A2 (en) * 1983-12-15 1985-06-26 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Glycidyl compound and process for preparing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146130A2 (en) * 1983-12-15 1985-06-26 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Glycidyl compound and process for preparing the same
EP0146130A3 (en) * 1983-12-15 1985-11-13 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Glycidyl compound and process for preparing the same

Also Published As

Publication number Publication date
IT1077192B (en) 1985-05-04
ZA773119B (en) 1978-04-26
HU177844B (en) 1981-12-28
FI771631A (en) 1977-11-26
AT356125B (en) 1980-04-10
BE855040A (en) 1977-11-25
IL52149A0 (en) 1977-07-31
ES458958A1 (en) 1978-02-16
ATA369877A (en) 1979-09-15
LU77390A1 (en) 1977-12-22
DK227077A (en) 1977-11-26
SE7706060L (en) 1977-11-26
JPS5312838A (en) 1978-02-04
NL7705581A (en) 1977-11-29
DE2623313A1 (en) 1977-12-15
CA1105041A (en) 1981-07-14
AU2543577A (en) 1978-11-30

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