FR2345446A1 - 2-(5-(aminocyclique)-ethyl-10, 11-dihydro-5h-dibenzo(a, d)cycloheptenyl-5)-5-alkyl-1,3,4-oxadiazoles, leur preparation et leur utilisation comme anti-diarrheiques - Google Patents

2-(5-(aminocyclique)-ethyl-10, 11-dihydro-5h-dibenzo(a, d)cycloheptenyl-5)-5-alkyl-1,3,4-oxadiazoles, leur preparation et leur utilisation comme anti-diarrheiques

Info

Publication number
FR2345446A1
FR2345446A1 FR7708547A FR7708547A FR2345446A1 FR 2345446 A1 FR2345446 A1 FR 2345446A1 FR 7708547 A FR7708547 A FR 7708547A FR 7708547 A FR7708547 A FR 7708547A FR 2345446 A1 FR2345446 A1 FR 2345446A1
Authority
FR
France
Prior art keywords
aminocyclic
oxadiazoles
cycloheptenyl
dibenzo
diarrhea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7708547A
Other languages
English (en)
French (fr)
Other versions
FR2345446B1 (OSRAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of FR2345446A1 publication Critical patent/FR2345446A1/fr
Application granted granted Critical
Publication of FR2345446B1 publication Critical patent/FR2345446B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7708547A 1976-03-22 1977-03-22 2-(5-(aminocyclique)-ethyl-10, 11-dihydro-5h-dibenzo(a, d)cycloheptenyl-5)-5-alkyl-1,3,4-oxadiazoles, leur preparation et leur utilisation comme anti-diarrheiques Granted FR2345446A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,886 US4012393A (en) 1976-03-22 1976-03-22 2-[5-(CYCLIC AMINO) ETHYL-10,11-DIHYDRO-5H-dibenzo[a,d]-cyclohepten-5- yl]-5

Publications (2)

Publication Number Publication Date
FR2345446A1 true FR2345446A1 (fr) 1977-10-21
FR2345446B1 FR2345446B1 (OSRAM) 1980-07-18

Family

ID=24684147

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7708547A Granted FR2345446A1 (fr) 1976-03-22 1977-03-22 2-(5-(aminocyclique)-ethyl-10, 11-dihydro-5h-dibenzo(a, d)cycloheptenyl-5)-5-alkyl-1,3,4-oxadiazoles, leur preparation et leur utilisation comme anti-diarrheiques

Country Status (6)

Country Link
US (1) US4012393A (OSRAM)
JP (1) JPS52113998A (OSRAM)
CA (1) CA1085825A (OSRAM)
DE (1) DE2712288A1 (OSRAM)
FR (1) FR2345446A1 (OSRAM)
GB (1) GB1520626A (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045442A (en) * 1976-01-05 1977-08-30 G. D. Searle & Co. 1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof
DK40890D0 (da) * 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US5888494A (en) * 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
EP1615646B2 (en) * 2003-04-08 2022-07-27 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
CA2682125C (en) 2007-03-29 2015-06-16 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
JP5469593B2 (ja) * 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
JP5358587B2 (ja) 2008-02-06 2013-12-04 プロジェニックス・ファーマシューティカルス・インコーポレイテッド （ｒ），（ｒ）−２，２’−ビス−メチルナルトレキソンの製造及び用途
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines

Also Published As

Publication number Publication date
CA1085825A (en) 1980-09-16
US4012393A (en) 1977-03-15
JPS52113998A (en) 1977-09-24
GB1520626A (en) 1978-08-09
FR2345446B1 (OSRAM) 1980-07-18
DE2712288A1 (de) 1977-10-06

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