JPS52113998A - 22*55*cyclicamino*ethyll10*111dihydroo 5hhbenzo*a*d*cycloheptenee55yl** 55alkyll1*3*44oxadiazole and homolog thereof - Google Patents

22*55*cyclicamino*ethyll10*111dihydroo 5hhbenzo*a*d*cycloheptenee55yl** 55alkyll1*3*44oxadiazole and homolog thereof

Info

Publication number
JPS52113998A
JPS52113998A JP3145677A JP3145677A JPS52113998A JP S52113998 A JPS52113998 A JP S52113998A JP 3145677 A JP3145677 A JP 3145677A JP 3145677 A JP3145677 A JP 3145677A JP S52113998 A JPS52113998 A JP S52113998A
Authority
JP
Japan
Prior art keywords
ethyll10
5hhbenzo
55alkyll1
cyclicamino
homolog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3145677A
Other languages
English (en)
Inventor
Shiyaheen Marukosu Chiyaaruzu
Fuwai Ien Chiyun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of JPS52113998A publication Critical patent/JPS52113998A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP3145677A 1976-03-22 1977-03-22 22*55*cyclicamino*ethyll10*111dihydroo 5hhbenzo*a*d*cycloheptenee55yl** 55alkyll1*3*44oxadiazole and homolog thereof Pending JPS52113998A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,886 US4012393A (en) 1976-03-22 1976-03-22 2-[5-(CYCLIC AMINO) ETHYL-10,11-DIHYDRO-5H-dibenzo[a,d]-cyclohepten-5- yl]-5

Publications (1)

Publication Number Publication Date
JPS52113998A true JPS52113998A (en) 1977-09-24

Family

ID=24684147

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3145677A Pending JPS52113998A (en) 1976-03-22 1977-03-22 22*55*cyclicamino*ethyll10*111dihydroo 5hhbenzo*a*d*cycloheptenee55yl** 55alkyll1*3*44oxadiazole and homolog thereof

Country Status (6)

Country Link
US (1) US4012393A (ja)
JP (1) JPS52113998A (ja)
CA (1) CA1085825A (ja)
DE (1) DE2712288A1 (ja)
FR (1) FR2345446A1 (ja)
GB (1) GB1520626A (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4045442A (en) * 1976-01-05 1977-08-30 G. D. Searle & Co. 1-(Substituted amino)alkanoyl-2-(dibenzoxazepine-10-carbonyl)hydrazines and derivatives thereof
DK40890D0 (da) * 1990-02-16 1990-02-16 Ferrosan As Substituerede urinstofforbindelser, deres fremstilling og anvendelse
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US5888494A (en) * 1996-03-12 1999-03-30 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
PT1615646E (pt) * 2003-04-08 2015-02-12 Progenics Pharm Inc Formulações farmacêuticas com metilnaltrexona
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) * 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
JP5469593B2 (ja) 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
TWI553009B (zh) 2007-03-29 2016-10-11 普吉尼製藥公司 末梢性類鴉片受體拮抗劑及其用途
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines

Also Published As

Publication number Publication date
GB1520626A (en) 1978-08-09
FR2345446B1 (ja) 1980-07-18
FR2345446A1 (fr) 1977-10-21
US4012393A (en) 1977-03-15
CA1085825A (en) 1980-09-16
DE2712288A1 (de) 1977-10-06

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