FR2344562A1 - (2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents - Google Patents

(2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents

Info

Publication number
FR2344562A1
FR2344562A1 FR7707998A FR7707998A FR2344562A1 FR 2344562 A1 FR2344562 A1 FR 2344562A1 FR 7707998 A FR7707998 A FR 7707998A FR 7707998 A FR7707998 A FR 7707998A FR 2344562 A1 FR2344562 A1 FR 2344562A1
Authority
FR
France
Prior art keywords
acetamido
amino
alkoxy
acyloxyphenyl
antibacterial agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7707998A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19762611645 external-priority patent/DE2611645A1/en
Priority claimed from DE19772701791 external-priority patent/DE2701791A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of FR2344562A1 publication Critical patent/FR2344562A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New cephalosporins of formula (I) and their esters and salts: In the formula R is H, 1-9C alkyl opt. substd. by F, Cl, Br, COOH, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl, or 1-10C alkoxy opt. substd. by F, Cl, Br, 1-5C alkoxy, 1-4C alkanoyloxy or 2-5C alkoxycarbonyl; R1 is H, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiazdiazol-5-yl. Cpds. (I) are broad-spectrum antibacterials, e.g. orally effective against Staph. aureus infections at a daily dose of 10-60 mg/kg. A typical cpd. is 7- D-2-amino-2-(3-propionyloxyphenyl) acetamido -3-methyl-3-cephem-4-carboxylic acid, which may be prepd. from 7- D-2-t-butyloxycarbonylamino-2-(3-hydroxyphenyl)acetamido -3-me- thyl-3-cephem-4-carboxylic acid.
FR7707998A 1976-03-19 1977-03-17 (2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents Withdrawn FR2344562A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19762611645 DE2611645A1 (en) 1976-03-19 1976-03-19 (2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents
DE19772701791 DE2701791A1 (en) 1977-01-18 1977-01-18 (2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents

Publications (1)

Publication Number Publication Date
FR2344562A1 true FR2344562A1 (en) 1977-10-14

Family

ID=25770226

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7707998A Withdrawn FR2344562A1 (en) 1976-03-19 1977-03-17 (2)-Amino-(2)-acyloxyphenyl-acetamido cephalosporins - for use as antibacterial agents

Country Status (7)

Country Link
JP (1) JPS52113997A (en)
AU (1) AU2334377A (en)
ES (1) ES456930A1 (en)
FR (1) FR2344562A1 (en)
IL (1) IL51651A0 (en)
NL (1) NL7703004A (en)
SE (1) SE7703115L (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2273546A1 (en) * 1974-06-05 1976-01-02 Bristol Myers Co NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2273546A1 (en) * 1974-06-05 1976-01-02 Bristol Myers Co NEW CEPHALOSPORIN DERIVATIVES, THEIR PREPARATION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM

Also Published As

Publication number Publication date
NL7703004A (en) 1977-09-21
IL51651A0 (en) 1977-05-31
JPS52113997A (en) 1977-09-24
SE7703115L (en) 1977-09-20
AU2334377A (en) 1978-09-21
ES456930A1 (en) 1978-05-16

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Legal Events

Date Code Title Description
ST Notification of lapse