FR2342268A1 - Spiro-cyclohexane-(1,2')-indane and -tetralin cpds. - prepd. from bis-carbalkoxyethyl-indane and -tetralin cpds. by Dieckmann reaction, having steroid hormone activity - Google Patents

Spiro-cyclohexane-(1,2')-indane and -tetralin cpds. - prepd. from bis-carbalkoxyethyl-indane and -tetralin cpds. by Dieckmann reaction, having steroid hormone activity

Info

Publication number
FR2342268A1
FR2342268A1 FR7705635A FR7705635A FR2342268A1 FR 2342268 A1 FR2342268 A1 FR 2342268A1 FR 7705635 A FR7705635 A FR 7705635A FR 7705635 A FR7705635 A FR 7705635A FR 2342268 A1 FR2342268 A1 FR 2342268A1
Authority
FR
France
Prior art keywords
cpds
indane
tetralin
oestrogenic
cyclohexane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7705635A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of FR2342268A1 publication Critical patent/FR2342268A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/675—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having three rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

New spiro-cyclohexane derivs. are of formula (I). In (I), R1 is a fused-on six-membered carbocyclic ring; R2 and R3 are each H, or form part of a pi -bonding system within the ring, or together form a C-C bond within such a pi-bonding system; R4 and R5 are each H or a monovalent organic gp., or R4+R5 is a divalent organic gp.; R6 is H or a monovalent organic gp.; R7 is H or together with R9 forms a C-C bond; R8 is H or a monovalent organic gp. or together with R9 forms a divalent organic gp.; R9 is H or a monovalent organic gp.; or R7+R9 is a C-C pi-bond, or R8+R9 is a divalent organic gp.; and n is 1 or 2. They are used e.g., to activate oestrogenic cpds. (e.g. stilboestrol), permitting high oestrogenic activity to be obtd. with low doses of oestrogens (this can be useful e.g. in contraceptive or cosmetic prepns.), where redn. of the side-effects of oestrogens is desirable). (I) also have e.g. oestrogenic, anti-oestrogenic, androgenic or anti-androgenic activity. Specific cpds. (I) include spiro3-ethoxycarbonylcyclohexane-1,21-indane -11,4-dione. In an example, this cpd is produced by gradually adding 2,2-bis(2-ethoxycarbonylethyl)-indanone under N2 to a stirred suspension of Na in dry toluene at 100 degrees and refluxing 4 hrs.
FR7705635A 1976-02-26 1977-02-25 Spiro-cyclohexane-(1,2')-indane and -tetralin cpds. - prepd. from bis-carbalkoxyethyl-indane and -tetralin cpds. by Dieckmann reaction, having steroid hormone activity Withdrawn FR2342268A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4607575 1976-02-26

Publications (1)

Publication Number Publication Date
FR2342268A1 true FR2342268A1 (en) 1977-09-23

Family

ID=10439756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7705635A Withdrawn FR2342268A1 (en) 1976-02-26 1977-02-25 Spiro-cyclohexane-(1,2')-indane and -tetralin cpds. - prepd. from bis-carbalkoxyethyl-indane and -tetralin cpds. by Dieckmann reaction, having steroid hormone activity

Country Status (3)

Country Link
JP (1) JPS52128366A (en)
DE (1) DE2708279A1 (en)
FR (1) FR2342268A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046134A1 (en) * 2000-12-08 2002-06-13 Karo Bio Ab Novel estrogen receptor ligands and methods iii

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046134A1 (en) * 2000-12-08 2002-06-13 Karo Bio Ab Novel estrogen receptor ligands and methods iii

Also Published As

Publication number Publication date
JPS52128366A (en) 1977-10-27
DE2708279A1 (en) 1977-09-08

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