FR2340736A1 - Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77) - Google Patents

Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77)

Info

Publication number
FR2340736A1
FR2340736A1 FR7603603A FR7603603A FR2340736A1 FR 2340736 A1 FR2340736 A1 FR 2340736A1 FR 7603603 A FR7603603 A FR 7603603A FR 7603603 A FR7603603 A FR 7603603A FR 2340736 A1 FR2340736 A1 FR 2340736A1
Authority
FR
France
Prior art keywords
antibilharziasis
derivs
dithiol
agents
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7603603A
Other languages
French (fr)
Other versions
FR2340736B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7603603A priority Critical patent/FR2340736A1/en
Priority to EG60/77A priority patent/EG13192A/en
Priority to NLAANVRAGE7701103,A priority patent/NL175823C/en
Priority to HU77RO00000913A priority patent/HU172527B/en
Priority to IL51402A priority patent/IL51402A/en
Priority to AR266483A priority patent/AR220892A1/en
Priority to JP1347177A priority patent/JPS52105181A/en
Priority to GB5368/77A priority patent/GB1520231A/en
Priority to PH19437A priority patent/PH12622A/en
Priority to SE7701459A priority patent/SE427273B/en
Priority to MW3/77A priority patent/MW377A1/en
Priority to AU22139/77A priority patent/AU505778B2/en
Priority to ZA770744A priority patent/ZA77744B/en
Priority to PT66174A priority patent/PT66174B/en
Priority to IE269/77A priority patent/IE44462B1/en
Priority to CA271,430A priority patent/CA1075239A/en
Priority to BE174798A priority patent/BE851261A/en
Priority to US05/766,967 priority patent/US4104386A/en
Priority to ZM13/77A priority patent/ZM1377A1/en
Priority to CH158177A priority patent/CH616161A5/fr
Priority to DK55677A priority patent/DK55677A/en
Priority to LU76727A priority patent/LU76727A1/xx
Priority to SU772450452A priority patent/SU837324A3/en
Priority to ES455789A priority patent/ES455789A1/en
Priority to DE2705582A priority patent/DE2705582C3/en
Priority to OA56068A priority patent/OA05566A/en
Priority to AT90177A priority patent/AT349028B/en
Priority to ES458019A priority patent/ES458019A1/en
Publication of FR2340736A1 publication Critical patent/FR2340736A1/en
Priority to US05/852,458 priority patent/US4145423A/en
Priority to AT71978A priority patent/AT349029B/en
Application granted granted Critical
Publication of FR2340736B1 publication Critical patent/FR2340736B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New 1,2-dithiol derivs. are of formula (I) (where Het is pyridazin-3-yl, or pyrimidin-2-yl, -4-yl or -5-yl, all opt. substd. with halogen, 1-4C alkyl, 1-4C alkoxy, mercapto, 1-4C alkylthio or di(1-4C)alkylamino). (I) possess chemotherapeutic properties and are esp. useful as antibilharziasis agents, and are of low toxicity. In an example, 47.2 g. phosphorus pentasulphide and 36 g. 3-(pyridazin-3-yl)-3-oxo-propionic acid ethyl ester in 360 ml. toluene were heated for 1 hr. at 110 degrees C to give 2.7 g. 5-(pyradixin-3-yl)-1,2-dithio-3-thione, m.pt. 250 degrees C.
FR7603603A 1976-02-10 1976-02-10 Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77) Granted FR2340736A1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
FR7603603A FR2340736A1 (en) 1976-02-10 1976-02-10 Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77)
EG60/77A EG13192A (en) 1976-02-10 1977-02-01 Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent
NLAANVRAGE7701103,A NL175823C (en) 1976-02-10 1977-02-02 PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH CHEMOTHERAPEUTIC ACTION, SO THE MEDICINAL PRODUCT OBTAINED, AND METHOD FOR THE PRODUCTION OF 1,2-DITHIOL DERIVATIVES, SUITABLE FOR USE THEREOF.
IL51402A IL51402A (en) 1976-02-10 1977-02-08 5-pyridazinyl(pyrimidyl)-1,2-dithiole-3-thione derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
AR266483A AR220892A1 (en) 1976-02-10 1977-02-08 PROCEDURE FOR PREPARING (PIRIDAZINIL-3) -5-DITIOL-1,2 TIONA-3
HU77RO00000913A HU172527B (en) 1976-02-10 1977-02-08 Process for producing new 1,2-dithiol derivatives
CH158177A CH616161A5 (en) 1976-02-10 1977-02-09
PH19437A PH12622A (en) 1976-02-10 1977-02-09 Derivatives of 1,2-dithiole
SE7701459A SE427273B (en) 1976-02-10 1977-02-09 PROCEDURE FOR PREPARING DERIVATIVES OF 1,2-DITIOL-3-TION WITH EFFECT ON BLOOD PARASITES
MW3/77A MW377A1 (en) 1976-02-10 1977-02-09 New derivatives of 1,2-dithiole
AU22139/77A AU505778B2 (en) 1976-02-10 1977-02-09 1, 2-dithiole derivatives
ZA770744A ZA77744B (en) 1976-02-10 1977-02-09 New derivatives of 1,2-dithiole
PT66174A PT66174B (en) 1976-02-10 1977-02-09 PROCESS FOR THE PREPARATION OF 1,2-DIIROL DERIVATIVES AND COMPOSITIONS CONTAINED THEREOF
IE269/77A IE44462B1 (en) 1976-02-10 1977-02-09 New derivatives of 1,2 dithiole
JP1347177A JPS52105181A (en) 1976-02-10 1977-02-09 Novel 1*22dithiol derivative
BE174798A BE851261A (en) 1976-02-10 1977-02-09 NEW DITHIOLE-1,2 DERIVATIVES
US05/766,967 US4104386A (en) 1976-02-10 1977-02-09 Derivatives of 1,2-dithiole and anti-bilharzia compositions thereof
ZM13/77A ZM1377A1 (en) 1976-02-10 1977-02-09 New derivatives of 1,2-dithiole
GB5368/77A GB1520231A (en) 1976-02-10 1977-02-09 Derivatives of 1,2-dithiole
DK55677A DK55677A (en) 1976-02-10 1977-02-09 PROCEDURE FOR THE PREPARATION OF 1,2-DITHIOL DERIVATIVES
LU76727A LU76727A1 (en) 1976-02-10 1977-02-09
CA271,430A CA1075239A (en) 1976-02-10 1977-02-09 1,2-dithiol derivatives, methods of preparation, compositions thereof
SU772450452A SU837324A3 (en) 1976-02-10 1977-02-10 Method of preparing derivatives of 1,2-dithiolane
ES455789A ES455789A1 (en) 1976-02-10 1977-02-10 Procedure for the preparation of new derivatives of ditiol-1,2. (Machine-translation by Google Translate, not legally binding)
DE2705582A DE2705582C3 (en) 1976-02-10 1977-02-10 5- (Pyridazin-3-yl) -1,2-dithiol-3-thione, its preparation and the compositions containing it
OA56068A OA05566A (en) 1976-02-10 1977-02-10 New 1,2-dithiole derivatives and their preparation process.
AT90177A AT349028B (en) 1976-02-10 1977-02-10 PROCESS FOR THE PRODUCTION OF NEW 1,2-DITHIOL DERIVATIVES
ES458019A ES458019A1 (en) 1976-02-10 1977-04-21 Derivatives of 1,2-dithiole and anti-bilharzia compositions thereof
US05/852,458 US4145423A (en) 1976-02-10 1977-11-17 Pyrimidinyl-1,2-dithiole compounds and anti-bilharzia compositions thereof
AT71978A AT349029B (en) 1976-02-10 1978-02-02 PROCESS FOR THE PRODUCTION OF NEW 1,2-DITHIOL DERIVATIVES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7603603A FR2340736A1 (en) 1976-02-10 1976-02-10 Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77)

Publications (2)

Publication Number Publication Date
FR2340736A1 true FR2340736A1 (en) 1977-09-09
FR2340736B1 FR2340736B1 (en) 1979-10-05

Family

ID=9168947

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7603603A Granted FR2340736A1 (en) 1976-02-10 1976-02-10 Pyridazinyl and pyrimidinyl-(1,2)-dithiol-(3)-dithione derivs. - useful as antibilharziasis agents (BE 9.8.77)

Country Status (5)

Country Link
BE (1) BE851261A (en)
FR (1) FR2340736A1 (en)
MW (1) MW377A1 (en)
ZA (1) ZA77744B (en)
ZM (1) ZM1377A1 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE CHEMISTRY OF HETEROCYCLIC COMPOUNDS", VOL, 21 PREMIERE PARTIE, INTERSCIENCE 1966 : MULTI-SULFUR AND SULFUR AND OXYGEN FIVE AND SIX-MEMBERED HETEROCYCLES, PAGES 347-404) *

Also Published As

Publication number Publication date
ZM1377A1 (en) 1978-07-21
MW377A1 (en) 1978-05-10
BE851261A (en) 1977-08-09
FR2340736B1 (en) 1979-10-05
ZA77744B (en) 1977-12-28

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