FR2333518A1 - Antithrombotic pyrazolone derivs. - with naphthyloxy-ethyl or diphenylyloxy-ethyl substit. in (2)-position - Google Patents

Antithrombotic pyrazolone derivs. - with naphthyloxy-ethyl or diphenylyloxy-ethyl substit. in (2)-position

Info

Publication number
FR2333518A1
FR2333518A1 FR7636544A FR7636544A FR2333518A1 FR 2333518 A1 FR2333518 A1 FR 2333518A1 FR 7636544 A FR7636544 A FR 7636544A FR 7636544 A FR7636544 A FR 7636544A FR 2333518 A1 FR2333518 A1 FR 2333518A1
Authority
FR
France
Prior art keywords
beta
ethyl
alkyl
substd
opt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7636544A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2333518A1 publication Critical patent/FR2333518A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pyrazolones of formula (I), including the tautomers are novel cpds. (where R1 = H, CF3 or an opt. substd. alkyl, aryl, aralkyl or heteroaryl group and R2 = unsubstd. naphthyl where R1 = H, CF3, >4C alkyl, heteroaryl or substd. aryl or aralkyl otherwise R2 = naphthyl substd. by 1-3 substituents independently chosen from halo, CF3, alkyl, alkenyl, alkoxy, alkylamino, cyano, CF3O, nitro, hydroxy, -SOn- alkyl or SOnCF3 ( n = 0-2), two of the substituents may be joined to form a 5-7 membered, opt. unsaturated, opt. branched isocyclic or heterocyclic ring which may contain 1 or 2 atoms of O or S or R2 = biphenylyl. Cpds. may be administered orally or parenterally for therapeutic or prophylactic treatment of thrombo-embolic disorders, blood clots, etc. Pred. daily doses are 0.1-10 mg/kg parenterally or 0.5-100 mg/kg orally. A typical product is (I) where R2 = beta-naphthyl and R1 = 2-methoxy-isobutyl prepd. from 2-(beta-napthyloxylethyl hydrazine and ethyl (beta, beta-dimethyl-beta-methoxy-propionyl) acetate.
FR7636544A 1975-12-05 1976-12-03 Antithrombotic pyrazolone derivs. - with naphthyloxy-ethyl or diphenylyloxy-ethyl substit. in (2)-position Withdrawn FR2333518A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752554703 DE2554703A1 (en) 1975-12-05 1975-12-05 SUBSTITUTED 2- (BETA-NAPHTHYLOXY) - AETHYLPYRAZOLONE

Publications (1)

Publication Number Publication Date
FR2333518A1 true FR2333518A1 (en) 1977-07-01

Family

ID=5963528

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7636544A Withdrawn FR2333518A1 (en) 1975-12-05 1976-12-03 Antithrombotic pyrazolone derivs. - with naphthyloxy-ethyl or diphenylyloxy-ethyl substit. in (2)-position

Country Status (8)

Country Link
JP (1) JPS5271466A (en)
BE (1) BE849048A (en)
DE (1) DE2554703A1 (en)
DK (1) DK546276A (en)
FR (1) FR2333518A1 (en)
LU (1) LU76329A1 (en)
NL (1) NL7613511A (en)
SE (1) SE7613537L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4521613A (en) * 1984-03-14 1985-06-04 International Flavors & Fragrances Inc. 4(Hydrocarbylthio)acetoacetic esters

Also Published As

Publication number Publication date
BE849048A (en) 1977-06-03
LU76329A1 (en) 1977-11-21
JPS5271466A (en) 1977-06-14
SE7613537L (en) 1977-06-06
NL7613511A (en) 1977-06-07
DE2554703A1 (en) 1977-06-08
DK546276A (en) 1977-06-06

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Legal Events

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