FR2331351A1 - Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent - Google Patents
Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennentInfo
- Publication number
- FR2331351A1 FR2331351A1 FR7534450A FR7534450A FR2331351A1 FR 2331351 A1 FR2331351 A1 FR 2331351A1 FR 7534450 A FR7534450 A FR 7534450A FR 7534450 A FR7534450 A FR 7534450A FR 2331351 A1 FR2331351 A1 FR 2331351A1
- Authority
- FR
- France
- Prior art keywords
- daunorubicin
- derivs
- mouse
- acyloxy
- doses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229960000975 daunorubicin Drugs 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- KQRWYZDETCDVGB-TZSSRYMLSA-N (7s,9s)-7-[(2r,4s,5s,6s)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-9-(2-bromoacetyl)-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CBr)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 KQRWYZDETCDVGB-TZSSRYMLSA-N 0.000 abstract 1
- WFVKIANRKSZMGB-UHFFFAOYSA-N 2,2-diethoxyacetic acid Chemical compound CCOC(C(O)=O)OCC WFVKIANRKSZMGB-UHFFFAOYSA-N 0.000 abstract 1
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 201000008275 breast carcinoma Diseases 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 229960003109 daunorubicin hydrochloride Drugs 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (27)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7534450A FR2331351A1 (fr) | 1975-11-12 | 1975-11-12 | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
NLAANVRAGE7612239,A NL170737C (nl) | 1975-11-12 | 1976-11-04 | Werkwijze voor het bereiden van tegen tumoren werkzame esters van adriamycine, alsmede voor het bereiden van geneesmiddelen met anti-tumoractiviteit. |
CA265,119A CA1072954A (en) | 1975-11-12 | 1976-11-08 | Derivatives of daunorubicin; their preparation and compositions thereof |
CS767234A CS209876B2 (en) | 1975-11-12 | 1976-11-09 | Method of preparation of the new daunorubicine derivatives |
SU762418213A SU659095A3 (ru) | 1975-11-12 | 1976-11-09 | Способ получени производных даунорубицина или их солей |
GB46807/76A GB1525180A (en) | 1975-11-12 | 1976-11-10 | Daunorubicin derivatives |
AU19506/76A AU504388B2 (en) | 1975-11-12 | 1976-11-10 | Daunorubicin derivatives |
IE248476A IE44076B1 (en) | 1975-11-12 | 1976-11-10 | Daunorubicin derivatives |
ZA766740A ZA766740B (en) | 1975-11-12 | 1976-11-10 | Daunorubicin derivatives |
NZ182591A NZ182591A (en) | 1975-11-12 | 1976-11-10 | 14-substituted-daunorubicins and pharmaceutical compositions |
PH19114A PH13709A (en) | 1975-11-12 | 1976-11-10 | Daunorubicin derivatives and pharmaceutical compositions containing same |
JP13510676A JPS5285161A (en) | 1975-11-12 | 1976-11-10 | Daunorbicine derivatives |
BE172264A BE848219A (fr) | 1975-11-12 | 1976-11-10 | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
LU76176A LU76176A1 (enrdf_load_stackoverflow) | 1975-11-12 | 1976-11-11 | |
SE7612613A SE421212B (sv) | 1975-11-12 | 1976-11-11 | Forfarande for framstellning av nya derivat av daunorubicin |
HU76RO00000903A HU172526B (hu) | 1975-11-12 | 1976-11-11 | Sposob poluchenija novykh proizvodnykh davnorubicina |
DK508776A DK508776A (da) | 1975-11-12 | 1976-11-11 | Fremgangsmade til fremstilling af derivater af daunorubicin eller syreadditionssalte deraf |
IL50897A IL50897A (en) | 1975-11-12 | 1976-11-11 | Daunorubicin derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
AR265428A AR213419A1 (es) | 1975-11-12 | 1976-11-11 | Procedimiento para preparar nuevos derivados de daunorubicina |
NO763857A NO143349C (no) | 1975-11-12 | 1976-11-11 | Analogifremgangsmaate for fremstilling av nye derivater av daunorubicin. |
CH1423376A CH606081A5 (enrdf_load_stackoverflow) | 1975-11-12 | 1976-11-11 | |
AT842876A AT347583B (de) | 1975-11-12 | 1976-11-12 | Verfahren zur herstellung von neuen daunoru- bicinderivaten und von deren saeureadditions- salzen |
ES453264A ES453264A1 (es) | 1975-11-12 | 1976-11-12 | Procedimiento de preparacion de derivados de daunorublicina. |
FI763251A FI62316C (fi) | 1975-11-12 | 1976-11-12 | Foerfarande foer framstaellning av di- eller trisubstituerade estrar av daunorubicinderivat vilka aer anvaendbara vid behandling av tumoerer |
YU02778/76A YU277876A (en) | 1975-11-12 | 1976-11-12 | Process for obtaining new derivatives of daunorubicin |
DE2651773A DE2651773C3 (de) | 1975-11-12 | 1976-11-12 | 14-Acyloxy-daunorubicine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
US05/849,761 US4225589A (en) | 1975-11-12 | 1977-11-09 | Daunorubicin derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7534450A FR2331351A1 (fr) | 1975-11-12 | 1975-11-12 | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2331351A1 true FR2331351A1 (fr) | 1977-06-10 |
FR2331351B1 FR2331351B1 (enrdf_load_stackoverflow) | 1979-09-21 |
Family
ID=9162284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7534450A Granted FR2331351A1 (fr) | 1975-11-12 | 1975-11-12 | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE848219A (enrdf_load_stackoverflow) |
FR (1) | FR2331351A1 (enrdf_load_stackoverflow) |
ZA (1) | ZA766740B (enrdf_load_stackoverflow) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2429795A2 (fr) * | 1978-06-27 | 1980-01-25 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6027714Y2 (ja) | 1979-11-10 | 1985-08-21 | 日産自動車株式会社 | シ−トベルトリトラクタ− |
-
1975
- 1975-11-12 FR FR7534450A patent/FR2331351A1/fr active Granted
-
1976
- 1976-11-10 BE BE172264A patent/BE848219A/xx not_active IP Right Cessation
- 1976-11-10 ZA ZA766740A patent/ZA766740B/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2429795A2 (fr) * | 1978-06-27 | 1980-01-25 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent |
Also Published As
Publication number | Publication date |
---|---|
ZA766740B (en) | 1977-10-26 |
FR2331351B1 (enrdf_load_stackoverflow) | 1979-09-21 |
BE848219A (fr) | 1977-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |