FR2329289A1 - Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column - Google Patents

Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column

Info

Publication number
FR2329289A1
FR2329289A1 FR7533467A FR7533467A FR2329289A1 FR 2329289 A1 FR2329289 A1 FR 2329289A1 FR 7533467 A FR7533467 A FR 7533467A FR 7533467 A FR7533467 A FR 7533467A FR 2329289 A1 FR2329289 A1 FR 2329289A1
Authority
FR
France
Prior art keywords
arginine
dna
resin
pref
soln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7533467A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7533467A priority Critical patent/FR2329289A1/en
Priority to BE161605A priority patent/BE835273A/en
Publication of FR2329289A1 publication Critical patent/FR2329289A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

Arginine deoxyribonucleate (I) is prepd. by (a) passing an aq. soln. of the Na salt of DNA through a column filled with an aq. suspension of a resin on which L-arginine (II) is adsorbed, (b) adjusting the pH of the effluent to a value close to neutrality with H2O, (c) stirring the effluent with acetone and ageing it at low temp. (d) washing the resulting ppte. with acetone and ether, and (e) drying the product in a warm air stream. The product is a powder with a water-solubility of ca. 10% and an ash content of 0.2% which can be administered orally or by intramuscular injection for the treatment of asthenia, it has a synergistic effect, combining the endocellular stimulating action of DNA and the hepatic detoxicating action of (II). The Na-DNA soln. is pref. centrifuged before contact with the (II)-resin column. The resin is pref. 'Amberlite CG 120' (RTM), pretreated with HCl and washed neutral with H2O. The arginine is adsorbed on the pretreated resin by contacting the latter with an 8% soln. of (II) and washing to neutrality. The whole process is pref. carried out at low temp. (esp. at ca 5 degrees C).
FR7533467A 1975-10-31 1975-10-31 Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column Withdrawn FR2329289A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7533467A FR2329289A1 (en) 1975-10-31 1975-10-31 Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column
BE161605A BE835273A (en) 1975-10-31 1975-11-05 PROCESS FOR PREPARING AN ARGININE SALT, IN PARTICULAR ARGININE DESOXYRIBONUCLEATE, SO OBTAINED SALT AND APPLICATION OF SALT FOR THE TREATMENT OF ASTHENIA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7533467A FR2329289A1 (en) 1975-10-31 1975-10-31 Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column

Publications (1)

Publication Number Publication Date
FR2329289A1 true FR2329289A1 (en) 1977-05-27

Family

ID=9161917

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7533467A Withdrawn FR2329289A1 (en) 1975-10-31 1975-10-31 Arginine deoxyribonucleate for asthenia treatment - prepd. by contact of sodium-DNA with L-arginine in a resin column

Country Status (2)

Country Link
BE (1) BE835273A (en)
FR (1) FR2329289A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2634374A1 (en) * 1988-07-19 1990-01-26 Serobiologiques Lab Sa AGENTS Photoprotective, CYTOPHOTOPROTECTEURS SKIN WITH photoprotective activity CONSTITUENT CELLS FUNCTIONAL SKIN, ESPECIALLY CELLS Langerhans, BASED COMPOUNDS NUCLEIC: NUCLEOPROTIDES, ribonucleotides and deoxyribonucleotides, ribonucleosides and deoxyribonucleosides, COSMETIC OR DERMO-PHARMACEUTICAL CONTAINING SUCH AGENT AND NEW COMPOUNDS IN ITSELF

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2634374A1 (en) * 1988-07-19 1990-01-26 Serobiologiques Lab Sa AGENTS Photoprotective, CYTOPHOTOPROTECTEURS SKIN WITH photoprotective activity CONSTITUENT CELLS FUNCTIONAL SKIN, ESPECIALLY CELLS Langerhans, BASED COMPOUNDS NUCLEIC: NUCLEOPROTIDES, ribonucleotides and deoxyribonucleotides, ribonucleosides and deoxyribonucleosides, COSMETIC OR DERMO-PHARMACEUTICAL CONTAINING SUCH AGENT AND NEW COMPOUNDS IN ITSELF

Also Published As

Publication number Publication date
BE835273A (en) 1976-03-01

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