FR2328468A2 - Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole - Google Patents

Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole

Info

Publication number
FR2328468A2
FR2328468A2 FR7532483A FR7532483A FR2328468A2 FR 2328468 A2 FR2328468 A2 FR 2328468A2 FR 7532483 A FR7532483 A FR 7532483A FR 7532483 A FR7532483 A FR 7532483A FR 2328468 A2 FR2328468 A2 FR 2328468A2
Authority
FR
France
Prior art keywords
piperidyl
indole
antidepressant
methoxy
antiemetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7532483A
Other languages
French (fr)
Other versions
FR2328468B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7532483A priority Critical patent/FR2328468A2/en
Priority to IL48508A priority patent/IL48508A/en
Priority to ES442910A priority patent/ES442910A1/en
Priority to DE2552869A priority patent/DE2552869C2/en
Priority to SE7513391A priority patent/SE408422B/en
Priority to US05/636,098 priority patent/US3993764A/en
Priority to GB2344/78A priority patent/GB1529330A/en
Priority to GB49210/75A priority patent/GB1529329A/en
Priority to CA240,857A priority patent/CA1089766A/en
Priority to MX004196U priority patent/MX3046E/en
Priority to AU87173/75A priority patent/AU498955B2/en
Priority to JP50145182A priority patent/JPS5186475A/ja
Priority to CH1594675A priority patent/CH605915A5/xx
Priority to NL7514255A priority patent/NL7514255A/en
Priority to LU73947A priority patent/LU73947A1/xx
Priority to DK553175AA priority patent/DK139580B/en
Priority to IE2675/75A priority patent/IE42618B1/en
Publication of FR2328468A2 publication Critical patent/FR2328468A2/en
Application granted granted Critical
Publication of FR2328468B2 publication Critical patent/FR2328468B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Pharmaceutical compositions contain as active substance >=1 cpd. of formula (I): (where R is H or 1-5C alkoxy; and R1 and R2 are H or 1-5C alkyl), e.g. 3-(4-piperidyl)-indole or 5-methoxy-3-(4-piperidyl)-indole, and/or >=1 acid addition salt. (I) have antidepressant and antiemetic properties as well as anti-Parkinson activity. They can be used for the treatment of psychic, behavioral and character disorders and in the treatment of akinetic states. Daily dosage for humans is e.g. 5-500 mg per day. p.o.
FR7532483A 1974-12-09 1975-10-23 Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole Granted FR2328468A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
FR7532483A FR2328468A2 (en) 1975-10-23 1975-10-23 Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole
IL48508A IL48508A (en) 1974-12-09 1975-11-20 Pharmaceutical compositions comprising piperidylindole derivatives
ES442910A ES442910A1 (en) 1974-12-09 1975-11-24 Treatment of depressive states and Parkinson{3 s disease
DE2552869A DE2552869C2 (en) 1974-12-09 1975-11-25 Pharmaceutical compositions containing piperidylindole derivatives
SE7513391A SE408422B (en) 1974-12-09 1975-11-27 ANALOGICAL PROCEDURE FOR PREPARING SALTS OF PIPERIDYL CONTENT DERIVATIVES
US05/636,098 US3993764A (en) 1974-12-09 1975-11-28 Treatment of depressive states and Parkinson's disease
CA240,857A CA1089766A (en) 1974-12-09 1975-12-01 Pharmaceutic applications of piperidyl-indole derivatives
GB49210/75A GB1529329A (en) 1974-12-09 1975-12-01 Pharmaceutical compositions containing piperidylindole derivatives
GB2344/78A GB1529330A (en) 1974-12-09 1975-12-01 Acid addition salts of 3-(4'-piperidyl)-indole derivative
AU87173/75A AU498955B2 (en) 1974-12-09 1975-12-02 3-(4'-piperidyl) indoles
MX004196U MX3046E (en) 1974-12-09 1975-12-02 PROCEDURE FOR THE PREPARATION OF ADDITION SALTS OF PIPERIDIL - INDOL DERIVATIVES
CH1594675A CH605915A5 (en) 1974-12-09 1975-12-08
JP50145182A JPS5186475A (en) 1974-12-09 1975-12-08
NL7514255A NL7514255A (en) 1974-12-09 1975-12-08 PROCESS FOR THE PREPARATION OF PIPERIDYLINDOLS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEY.
LU73947A LU73947A1 (en) 1974-12-09 1975-12-08
DK553175AA DK139580B (en) 1974-12-09 1975-12-08 Analogous process for the preparation of addition salts of piperidylindole derivatives.
IE2675/75A IE42618B1 (en) 1974-12-09 1975-12-09 New pharmaceutical compositions containing piperidyl-indole derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7532483A FR2328468A2 (en) 1975-10-23 1975-10-23 Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole

Publications (2)

Publication Number Publication Date
FR2328468A2 true FR2328468A2 (en) 1977-05-20
FR2328468B2 FR2328468B2 (en) 1978-08-25

Family

ID=9161570

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7532483A Granted FR2328468A2 (en) 1974-12-09 1975-10-23 Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole

Country Status (1)

Country Link
FR (1) FR2328468A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003200A2 (en) * 1978-01-16 1979-07-25 Roussel-Uclaf Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0003200A2 (en) * 1978-01-16 1979-07-25 Roussel-Uclaf Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them
EP0003200A3 (en) * 1978-01-16 1979-08-08 Roussel-Uclaf Use of tetrahydropyridinyl indole derivatives as medicines, and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2328468B2 (en) 1978-08-25

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