GB1025439A - Nitrofuryl substituted oxadiazoles - Google Patents

Nitrofuryl substituted oxadiazoles

Info

Publication number
GB1025439A
GB1025439A GB40925/64A GB4092564A GB1025439A GB 1025439 A GB1025439 A GB 1025439A GB 40925/64 A GB40925/64 A GB 40925/64A GB 4092564 A GB4092564 A GB 4092564A GB 1025439 A GB1025439 A GB 1025439A
Authority
GB
United Kingdom
Prior art keywords
alkyl
furyl
thienyl
halo
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40925/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB1025439A publication Critical patent/GB1025439A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/70—Nitro radicals
    • C07D307/71—Nitro radicals attached in position 5
    • C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
    • C07D307/73—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by amino or imino, or substituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of formula <FORM:1025439/C2/1> in which R is hydrogen, alkyl, halo-alkyl, phenyl, halophenyl, aralkyl, pyridyl, furyl, thienyl, pyrimidyl, oxazolyl, isoxazolyl, alkoxyphenyl, quinolyl, pyrazolyl, isoquinolyl, pyrazinyl, thiazolyl, imidazolyl, aryloxy-alkyl, hydroxyphenyl, aminophenyl, nitrophenyl, halo-sulphonamidophenyl, alkylthiophenyl, sulphonamidophenyl, carboalkoxy, carboalkoxyalkyl, carboalkoxyvinyl, alkenyl, halo-furyl, halo-thienyl, furyl-alkyl or thienyl-alkyl, wherein the alkyl and alkoxy radicals have 1-5 carbon atoms, and the preparation thereof by heating to its melting point a compound of formula <FORM:1025439/C2/2> to liberate water and effect ring closure.ALSO:Therapeutic compositions which are useful as althelminthics and in the treatment of trichomonas vaginalis infection, and which may be administered orally or topically, contain as active ingredient compounds of formula <FORM:1025439/A5-A6/1> in which R is hydrogen, alkyl, haloalkyl, phenyl, halophenyl, aralkyl, pyridyl, furyl, thienyl, pyrimidyl, oxazolyl, isoxazolyl, alkoxyphenyl, quinolyl, pyrazolyl, isoquinolyl, pyrazinyl, thiazolyl, imidazolyl, aryloxyalkyl, hydroxyphenyl, aminophenyl, nitrophenyl, halosulphonamidophenyl, alkylthiophenyl, sulphonamidophenyl, carboalkoxy carboalkoxyalkyl, carboalkoxyvinyl, alkenyl, halofuryl, halothienyl, furylalkyl and thienylalkyl, wherein "alkyl" and "alkoxy" are straight or branched chain radicals containing 1-5 carbon atoms. The compounds of formula A are also useful as anti-bacterial or antifungal agents and can be employed as the active, toxic constituents of disinfectant compositions. They may be dispersed on an inert solid or dissolved in a liquid and applied as a dust or spray.
GB40925/64A 1963-10-09 1964-10-07 Nitrofuryl substituted oxadiazoles Expired GB1025439A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31486363A 1963-10-09 1963-10-09
US53770766A 1966-03-28 1966-03-28

Publications (1)

Publication Number Publication Date
GB1025439A true GB1025439A (en) 1966-04-06

Family

ID=26979599

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40925/64A Expired GB1025439A (en) 1963-10-09 1964-10-07 Nitrofuryl substituted oxadiazoles

Country Status (4)

Country Link
US (1) US3478049A (en)
BR (1) BR6463315D0 (en)
FR (1) FR4273M (en)
GB (1) GB1025439A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493565A (en) * 1966-03-14 1970-02-03 Squibb & Sons Inc 3-amino-5-(nitrofuryl)-1,2,4-oxadiazole derivatives
EP1047425A1 (en) * 1997-12-17 2000-11-02 Merck & Co., Inc. Integrin receptor antagonists

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4007185A (en) * 1967-01-31 1977-02-08 Abbott Laboratories 3,5-Substituted-1,2,4-oxadiazole inner quaternary ammonium salts
US3651054A (en) * 1967-01-31 1972-03-21 Abbott Lab 3 5-disubstituted 1 2 4-oxadiazoles
US3991067A (en) * 1971-05-19 1976-11-09 Glaxo Laboratories Limited Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group
US3857843A (en) * 1972-09-11 1974-12-31 American Cyanamid Co Cyclopropyl 1,2,4-oxadiazolyldiazines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337541A (en) * 1964-12-28 1967-08-22 Fujisawa Pharmacentical Co Ltd 5-[2-(5-nitro-2-furyl) vinyl]-1, 3, 4-oxadiazole derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3493565A (en) * 1966-03-14 1970-02-03 Squibb & Sons Inc 3-amino-5-(nitrofuryl)-1,2,4-oxadiazole derivatives
EP1047425A1 (en) * 1997-12-17 2000-11-02 Merck & Co., Inc. Integrin receptor antagonists
EP1047425A4 (en) * 1997-12-17 2009-04-22 Merck & Co Inc Integrin receptor antagonists

Also Published As

Publication number Publication date
BR6463315D0 (en) 1973-07-17
FR4273M (en) 1966-07-11
US3478049A (en) 1969-11-11

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