GB1025439A - Nitrofuryl substituted oxadiazoles - Google Patents
Nitrofuryl substituted oxadiazolesInfo
- Publication number
- GB1025439A GB1025439A GB40925/64A GB4092564A GB1025439A GB 1025439 A GB1025439 A GB 1025439A GB 40925/64 A GB40925/64 A GB 40925/64A GB 4092564 A GB4092564 A GB 4092564A GB 1025439 A GB1025439 A GB 1025439A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- furyl
- thienyl
- halo
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/70—Nitro radicals
- C07D307/71—Nitro radicals attached in position 5
- C07D307/72—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2
- C07D307/73—Nitro radicals attached in position 5 with hydrocarbon radicals, substituted by nitrogen-containing radicals, attached in position 2 by amino or imino, or substituted amino or imino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1025439/C2/1> in which R is hydrogen, alkyl, halo-alkyl, phenyl, halophenyl, aralkyl, pyridyl, furyl, thienyl, pyrimidyl, oxazolyl, isoxazolyl, alkoxyphenyl, quinolyl, pyrazolyl, isoquinolyl, pyrazinyl, thiazolyl, imidazolyl, aryloxy-alkyl, hydroxyphenyl, aminophenyl, nitrophenyl, halo-sulphonamidophenyl, alkylthiophenyl, sulphonamidophenyl, carboalkoxy, carboalkoxyalkyl, carboalkoxyvinyl, alkenyl, halo-furyl, halo-thienyl, furyl-alkyl or thienyl-alkyl, wherein the alkyl and alkoxy radicals have 1-5 carbon atoms, and the preparation thereof by heating to its melting point a compound of formula <FORM:1025439/C2/2> to liberate water and effect ring closure.ALSO:Therapeutic compositions which are useful as althelminthics and in the treatment of trichomonas vaginalis infection, and which may be administered orally or topically, contain as active ingredient compounds of formula <FORM:1025439/A5-A6/1> in which R is hydrogen, alkyl, haloalkyl, phenyl, halophenyl, aralkyl, pyridyl, furyl, thienyl, pyrimidyl, oxazolyl, isoxazolyl, alkoxyphenyl, quinolyl, pyrazolyl, isoquinolyl, pyrazinyl, thiazolyl, imidazolyl, aryloxyalkyl, hydroxyphenyl, aminophenyl, nitrophenyl, halosulphonamidophenyl, alkylthiophenyl, sulphonamidophenyl, carboalkoxy carboalkoxyalkyl, carboalkoxyvinyl, alkenyl, halofuryl, halothienyl, furylalkyl and thienylalkyl, wherein "alkyl" and "alkoxy" are straight or branched chain radicals containing 1-5 carbon atoms. The compounds of formula A are also useful as anti-bacterial or antifungal agents and can be employed as the active, toxic constituents of disinfectant compositions. They may be dispersed on an inert solid or dissolved in a liquid and applied as a dust or spray.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31486363A | 1963-10-09 | 1963-10-09 | |
US53770766A | 1966-03-28 | 1966-03-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1025439A true GB1025439A (en) | 1966-04-06 |
Family
ID=26979599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB40925/64A Expired GB1025439A (en) | 1963-10-09 | 1964-10-07 | Nitrofuryl substituted oxadiazoles |
Country Status (4)
Country | Link |
---|---|
US (1) | US3478049A (en) |
BR (1) | BR6463315D0 (en) |
FR (1) | FR4273M (en) |
GB (1) | GB1025439A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3493565A (en) * | 1966-03-14 | 1970-02-03 | Squibb & Sons Inc | 3-amino-5-(nitrofuryl)-1,2,4-oxadiazole derivatives |
EP1047425A1 (en) * | 1997-12-17 | 2000-11-02 | Merck & Co., Inc. | Integrin receptor antagonists |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4007185A (en) * | 1967-01-31 | 1977-02-08 | Abbott Laboratories | 3,5-Substituted-1,2,4-oxadiazole inner quaternary ammonium salts |
US3651054A (en) * | 1967-01-31 | 1972-03-21 | Abbott Lab | 3 5-disubstituted 1 2 4-oxadiazoles |
US3991067A (en) * | 1971-05-19 | 1976-11-09 | Glaxo Laboratories Limited | Mono- or disubstituted 1,2,4,oxadiazoles which are substituted by at least 1-N-substituted carbamoyl group |
US3857843A (en) * | 1972-09-11 | 1974-12-31 | American Cyanamid Co | Cyclopropyl 1,2,4-oxadiazolyldiazines |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3337541A (en) * | 1964-12-28 | 1967-08-22 | Fujisawa Pharmacentical Co Ltd | 5-[2-(5-nitro-2-furyl) vinyl]-1, 3, 4-oxadiazole derivatives |
-
1964
- 1964-10-07 GB GB40925/64A patent/GB1025439A/en not_active Expired
- 1964-10-09 BR BR163315/64A patent/BR6463315D0/en unknown
-
1965
- 1965-01-05 FR FR808A patent/FR4273M/fr not_active Expired
-
1966
- 1966-03-28 US US537707A patent/US3478049A/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3493565A (en) * | 1966-03-14 | 1970-02-03 | Squibb & Sons Inc | 3-amino-5-(nitrofuryl)-1,2,4-oxadiazole derivatives |
EP1047425A1 (en) * | 1997-12-17 | 2000-11-02 | Merck & Co., Inc. | Integrin receptor antagonists |
EP1047425A4 (en) * | 1997-12-17 | 2009-04-22 | Merck & Co Inc | Integrin receptor antagonists |
Also Published As
Publication number | Publication date |
---|---|
BR6463315D0 (en) | 1973-07-17 |
FR4273M (en) | 1966-07-11 |
US3478049A (en) | 1969-11-11 |
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