FR2293931A1 - Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole - Google Patents
Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indoleInfo
- Publication number
- FR2293931A1 FR2293931A1 FR7440233A FR7440233A FR2293931A1 FR 2293931 A1 FR2293931 A1 FR 2293931A1 FR 7440233 A FR7440233 A FR 7440233A FR 7440233 A FR7440233 A FR 7440233A FR 2293931 A1 FR2293931 A1 FR 2293931A1
- Authority
- FR
- France
- Prior art keywords
- piperidyl
- indole
- antidepressant
- methoxy
- antiemetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Pharmaceutical compositions contain as active substance >=1 cpd. of formula (I): (where R is H or 1-5C alkoxy; and R1 and R2 are H or 1-5C alkyl), e.g. 3-(4-piperidyl)-indole or 5-methoxy-3-(4-piperidyl)-indole, and/or >=1 acid addition salt. (I) have antidepressant and antiemetic properties as well as anti-Parkinson activity. They can be used for the treatment of psychic, behavioral and character disorders and in the treatment of akinetic states. Daily dosage for humans is e.g. 5-500 mg per day. p.o.
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7440233A FR2293931A1 (en) | 1974-12-09 | 1974-12-09 | Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole |
IL48508A IL48508A (en) | 1974-12-09 | 1975-11-20 | Pharmaceutical compositions comprising piperidylindole derivatives |
ES442910A ES442910A1 (en) | 1974-12-09 | 1975-11-24 | Treatment of depressive states and Parkinson{3 s disease |
DE2552869A DE2552869C2 (en) | 1974-12-09 | 1975-11-25 | Pharmaceutical compositions containing piperidylindole derivatives |
ZA7444A ZA757444B (en) | 1974-12-09 | 1975-11-26 | A pharmaceutical composition containing at least one piperidyl-indole |
SE7513391A SE408422B (en) | 1974-12-09 | 1975-11-27 | ANALOGICAL PROCEDURE FOR PREPARING SALTS OF PIPERIDYL CONTENT DERIVATIVES |
US05/636,098 US3993764A (en) | 1974-12-09 | 1975-11-28 | Treatment of depressive states and Parkinson's disease |
GB2344/78A GB1529330A (en) | 1974-12-09 | 1975-12-01 | Acid addition salts of 3-(4'-piperidyl)-indole derivative |
CA240,857A CA1089766A (en) | 1974-12-09 | 1975-12-01 | Pharmaceutic applications of piperidyl-indole derivatives |
GB49210/75A GB1529329A (en) | 1974-12-09 | 1975-12-01 | Pharmaceutical compositions containing piperidylindole derivatives |
AU87173/75A AU498955B2 (en) | 1974-12-09 | 1975-12-02 | 3-(4'-piperidyl) indoles |
MX004196U MX3046E (en) | 1974-12-09 | 1975-12-02 | PROCEDURE FOR THE PREPARATION OF ADDITION SALTS OF PIPERIDIL - INDOL DERIVATIVES |
LU73947A LU73947A1 (en) | 1974-12-09 | 1975-12-08 | |
BE162540A BE836391A (en) | 1974-12-09 | 1975-12-08 | NEW PHARMACEUTICAL COMPOSITIONS CONTAINING A DERIVATIVE OF PIPERIDYL INDOLE OR ONE OF ITS SALTS |
JP50145182A JPS5186475A (en) | 1974-12-09 | 1975-12-08 | |
NL7514255A NL7514255A (en) | 1974-12-09 | 1975-12-08 | PROCESS FOR THE PREPARATION OF PIPERIDYLINDOLS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEY. |
DK553175AA DK139580B (en) | 1974-12-09 | 1975-12-08 | Analogous process for the preparation of addition salts of piperidylindole derivatives. |
CH1594675A CH605915A5 (en) | 1974-12-09 | 1975-12-08 | |
IE2675/75A IE42618B1 (en) | 1974-12-09 | 1975-12-09 | New pharmaceutical compositions containing piperidyl-indole derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7440233A FR2293931A1 (en) | 1974-12-09 | 1974-12-09 | Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2293931A1 true FR2293931A1 (en) | 1976-07-09 |
FR2293931B1 FR2293931B1 (en) | 1978-07-21 |
Family
ID=9145754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7440233A Granted FR2293931A1 (en) | 1974-12-09 | 1974-12-09 | Antidepressant, antiemetic and anti Parkinson 3-(4-piperidyl) indoles - e.g. 5-methoxy-3-(4-piperidyl)indole |
Country Status (3)
Country | Link |
---|---|
BE (1) | BE836391A (en) |
FR (1) | FR2293931A1 (en) |
ZA (1) | ZA757444B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003200A2 (en) * | 1978-01-16 | 1979-07-25 | Roussel-Uclaf | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them |
-
1974
- 1974-12-09 FR FR7440233A patent/FR2293931A1/en active Granted
-
1975
- 1975-11-26 ZA ZA7444A patent/ZA757444B/en unknown
- 1975-12-08 BE BE162540A patent/BE836391A/en not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0003200A2 (en) * | 1978-01-16 | 1979-07-25 | Roussel-Uclaf | Tetrahydropyridinyl indole derivatives and their salts for use in a method for therapeutic treatment of the human or animal body and pharmaceutical compositions containing them |
EP0003200A3 (en) * | 1978-01-16 | 1979-08-08 | Roussel-Uclaf | Use of tetrahydropyridinyl indole derivatives as medicines, and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
FR2293931B1 (en) | 1978-07-21 |
BE836391A (en) | 1976-06-08 |
ZA757444B (en) | 1977-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |