FR2323699A1 - Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173 - Google Patents

Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173

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Publication number
FR2323699A1
FR2323699A1 FR7528217A FR7528217A FR2323699A1 FR 2323699 A1 FR2323699 A1 FR 2323699A1 FR 7528217 A FR7528217 A FR 7528217A FR 7528217 A FR7528217 A FR 7528217A FR 2323699 A1 FR2323699 A1 FR 2323699A1
Authority
FR
France
Prior art keywords
acetate
antibiotic
degrees
rivalis
chloquinomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7528217A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Priority to FR7528217A priority Critical patent/FR2323699A1/en
Publication of FR2323699A1 publication Critical patent/FR2323699A1/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

New antibiotic A-3459A ("chloquinomycin") has characteristics which include C 56.25%, H 3.64%, O 32.07%, Cl 6.63%, N 0%; molecular weight 614 (vapour phase osmometry; m.pt. 228-238 degrees C (dec.); alpha 20D=+15 degrees (c=0.01, CHCl3) readily soluble in dimethylformamide, dimethyl sulphoxide, pyridine and aqueous NaOH; soluble in acetone, ethyl acetate, CHCl3, benzene, Et2O, acetic acid, MeOH, EtOH and BuOH; insoluble in n-hexane, petroleum ether and water. The acetate of antibiotic A-3459A (C 59.5%, H 4.25%, N 0%; m.pt. 188-200 degrees C) is also claimed. A-3459A and its acetate have antibiotic activity against gram-positive organisms, including antibiotic-resistant strains. MIC's of A-3459A and its acetate are given e.g. A3459A against Staph. aureus 209P, B. subtilis PCI 219 and E. coli they are 0.8, 0.4 and >50 mcg/ml, respectively. A-3459A is produced by cultivation of Streptomyces californicus var. rivalis ATCC 31173 and is converted into its acetate by reacting with acetic anhydride in pyridine. Cultivation conditions comprise aerobic conditions, ca 20-38 degrees C and pH ca 5.5-8.5 in a nutrient medium contg. usual carbon and nitrogen sources and inorganic salts.
FR7528217A 1975-09-15 1975-09-15 Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173 Withdrawn FR2323699A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7528217A FR2323699A1 (en) 1975-09-15 1975-09-15 Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7528217A FR2323699A1 (en) 1975-09-15 1975-09-15 Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173

Publications (1)

Publication Number Publication Date
FR2323699A1 true FR2323699A1 (en) 1977-04-08

Family

ID=9159983

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7528217A Withdrawn FR2323699A1 (en) 1975-09-15 1975-09-15 Antibiotic A-3459A, or chloquinomycin, and its acetate - produced by cultivating Streptomyces californicus var rivalis ATCC 31173

Country Status (1)

Country Link
FR (1) FR2323699A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178902A2 (en) * 1984-10-15 1986-04-23 Kyowa Hakko Kogyo Co., Ltd. Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0178902A2 (en) * 1984-10-15 1986-04-23 Kyowa Hakko Kogyo Co., Ltd. Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same
EP0178902A3 (en) * 1984-10-15 1987-10-14 Kyowa Hakko Kogyo Co., Ltd. Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same

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