FR2322867A1 - Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides - Google Patents

Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides

Info

Publication number
FR2322867A1
FR2322867A1 FR7527449A FR7527449A FR2322867A1 FR 2322867 A1 FR2322867 A1 FR 2322867A1 FR 7527449 A FR7527449 A FR 7527449A FR 7527449 A FR7527449 A FR 7527449A FR 2322867 A1 FR2322867 A1 FR 2322867A1
Authority
FR
France
Prior art keywords
quinuclidinol
opt
converted
hydrohalides
esterified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7527449A
Other languages
French (fr)
Other versions
FR2322867B1 (en
Inventor
Louis-Marc Bezou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Compagnie Chimique Merck Sharp and Dohme SA
Original Assignee
Compagnie Chimique Merck Sharp and Dohme SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compagnie Chimique Merck Sharp and Dohme SA filed Critical Compagnie Chimique Merck Sharp and Dohme SA
Priority to FR7527449A priority Critical patent/FR2322867A1/en
Priority to DE19762640209 priority patent/DE2640209A1/en
Publication of FR2322867A1 publication Critical patent/FR2322867A1/en
Application granted granted Critical
Publication of FR2322867B1 publication Critical patent/FR2322867B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

3-Quinuclidinol is reacted directly with a carboxylic acid anhydride, esp. acetic-, propionic- or butyric anhydride. Ester obtd. is opt. converted to a hydrohalide, by reaction with a hydrogen halide source (pref. HCl (gas), carboxylic acid halide, esp. corresp. to the anhydride used). Prods., e.g. 3-acetoxy-quinuclidine hydrochloride, have pharmacological properties, and can be prepd. on a large scale, in high yields.
FR7527449A 1975-09-08 1975-09-08 Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides Granted FR2322867A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7527449A FR2322867A1 (en) 1975-09-08 1975-09-08 Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides
DE19762640209 DE2640209A1 (en) 1975-09-08 1976-09-07 PROCESS FOR THE PREPARATION OF 3-QUINUCLIDINOLESTERS AND THEIR HYDROHALOGENIDES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7527449A FR2322867A1 (en) 1975-09-08 1975-09-08 Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides

Publications (2)

Publication Number Publication Date
FR2322867A1 true FR2322867A1 (en) 1977-04-01
FR2322867B1 FR2322867B1 (en) 1979-09-14

Family

ID=9159711

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7527449A Granted FR2322867A1 (en) 1975-09-08 1975-09-08 Ester prepn. from quinuclidinol - esterified with carboxylic anhydrides and opt. converted to hydrohalides

Country Status (2)

Country Link
DE (1) DE2640209A1 (en)
FR (1) FR2322867A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036218A2 (en) * 1980-03-19 1981-09-23 D and D S.r.l. Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052645B1 (en) * 1980-06-03 1987-05-13 Research Corporation Gamma-emitting receptor-binding quinuclidinyl benzilates methods of preparation thereof and imaging and assay methods utilizing same
US4431627A (en) * 1980-06-03 1984-02-14 Research Corporation Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0036218A2 (en) * 1980-03-19 1981-09-23 D and D S.r.l. Salts of the 3-hydroxy quinuclidine esters of a phenoxycarboxylic acid, a process for the preparation thereof, and related pharmaceutical compositions
EP0036218A3 (en) * 1980-03-19 1981-12-30 D And D S.R.L. Quinuclidinic esters and derivatives of phenoxycarboxylic acids, a process for the preparation thereof, and related pharmaceutical compositions

Also Published As

Publication number Publication date
FR2322867B1 (en) 1979-09-14
DE2640209A1 (en) 1977-03-17

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