FR2318632A1 - SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries - Google Patents

SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Info

Publication number
FR2318632A1
FR2318632A1 FR7523715A FR7523715A FR2318632A1 FR 2318632 A1 FR2318632 A1 FR 2318632A1 FR 7523715 A FR7523715 A FR 7523715A FR 7523715 A FR7523715 A FR 7523715A FR 2318632 A1 FR2318632 A1 FR 2318632A1
Authority
FR
France
Prior art keywords
substd
esp
treating
useful
dental caries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7523715A
Other languages
French (fr)
Other versions
FR2318632B1 (en
Inventor
Henri Cousse
Gilbert Mouzin
Jean-Claude Vezin
Lucien Dussourd D Hinterland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7523715A priority Critical patent/FR2318632A1/en
Priority to DE19762633028 priority patent/DE2633028A1/en
Priority to GB3083976A priority patent/GB1575915A/en
Priority to CH949076A priority patent/CH598220A5/xx
Priority to ES450129A priority patent/ES450129A1/en
Publication of FR2318632A1 publication Critical patent/FR2318632A1/en
Application granted granted Critical
Publication of FR2318632B1 publication Critical patent/FR2318632B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Pyridinium salts of formula (I) are new: (R1 = H or alkyl; R2, at the 2 or 3 posn., is CH2OH, CONH.CH2CH2OH, morpholinocarbonyl or COOR3; R3 = alkyl). They are prepd. by conventional salt formation between R1F and R2-substd. pyridines. (I) are used for treatment or prophylaxis of parodontopathia, dental disease and esp. caries. They are stable in aq. soln., have high ionisation constants, are non-toxic and have good F transport properties. They also strengthen the gums and inhibit formation of plaque and tartar. A specifically claimed cpd., pyrid-3-ylmethanol hydro-fluoride, was prepd. by reacting pyrid-3-ylmethanol with an equiv. of aq. HF.
FR7523715A 1975-07-25 1975-07-25 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries Granted FR2318632A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR7523715A FR2318632A1 (en) 1975-07-25 1975-07-25 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries
DE19762633028 DE2633028A1 (en) 1975-07-25 1976-07-22 PYRIDINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
GB3083976A GB1575915A (en) 1975-07-25 1976-07-23 Pyridine derived fluorides and pharmaceutical compositions containing them
CH949076A CH598220A5 (en) 1975-07-25 1976-07-23
ES450129A ES450129A1 (en) 1975-07-25 1976-07-24 Procedure for the preparation of 3-pyridil-methanol fluorhydrate. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7523715A FR2318632A1 (en) 1975-07-25 1975-07-25 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Publications (2)

Publication Number Publication Date
FR2318632A1 true FR2318632A1 (en) 1977-02-18
FR2318632B1 FR2318632B1 (en) 1978-10-06

Family

ID=9158497

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7523715A Granted FR2318632A1 (en) 1975-07-25 1975-07-25 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Country Status (2)

Country Link
ES (1) ES450129A1 (en)
FR (1) FR2318632A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534474A1 (en) * 1982-10-15 1984-04-20 Fabre Sa Pierre Dentifrice composition
WO1988008697A1 (en) * 1987-05-04 1988-11-17 Blendax-Werke R. Schneider Gmbh & Co. Toothpaste
FR2915386A1 (en) * 2007-04-24 2008-10-31 Pierre Fabre Medicament Sa USE OF AQUEOUS EXTRACT OF GRAPE PEPINS IN ASSOCIATION WITH AT LEAST ONE FLUOR SALT AGAINST THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND THE COMPOSITIONS COMPRISING SAID ASSOCIATION
WO2019025622A1 (en) 2017-08-04 2019-02-07 Pierre Fabre Medicament Composition comprising a myrtle extract and a fluorine salt for oral application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2660582A (en) * 1950-06-30 1953-11-24 Cilag Ltd Quaternary nicotinic acid amide derivatives and production thereof
FR1297708A (en) * 1958-05-29 1962-07-06 Gaba Ag Quaternary ammonium fluorides and their manufacturing processes
FR2172906A1 (en) * 1972-02-25 1973-10-05 Fabre Sa Pierre Salts of 3-pyridyl methanol derivs - vasodilators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2660582A (en) * 1950-06-30 1953-11-24 Cilag Ltd Quaternary nicotinic acid amide derivatives and production thereof
FR1297708A (en) * 1958-05-29 1962-07-06 Gaba Ag Quaternary ammonium fluorides and their manufacturing processes
FR2172906A1 (en) * 1972-02-25 1973-10-05 Fabre Sa Pierre Salts of 3-pyridyl methanol derivs - vasodilators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ARZNEIMITTELFORSCHUNG, 15, 1965 NO. 12, PAGES 1421-28) *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534474A1 (en) * 1982-10-15 1984-04-20 Fabre Sa Pierre Dentifrice composition
WO1988008697A1 (en) * 1987-05-04 1988-11-17 Blendax-Werke R. Schneider Gmbh & Co. Toothpaste
EP0291747A1 (en) * 1987-05-04 1988-11-23 Blendax GmbH Toothpaste
FR2915386A1 (en) * 2007-04-24 2008-10-31 Pierre Fabre Medicament Sa USE OF AQUEOUS EXTRACT OF GRAPE PEPINS IN ASSOCIATION WITH AT LEAST ONE FLUOR SALT AGAINST THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND THE COMPOSITIONS COMPRISING SAID ASSOCIATION
WO2008132149A1 (en) * 2007-04-24 2008-11-06 Pierre Fabre Medicament Use of an aqueous grape seed extract combined with at least one fluorine salt to combat the formation or accumulation of dental biofilm and compositions comprising said combination
WO2019025622A1 (en) 2017-08-04 2019-02-07 Pierre Fabre Medicament Composition comprising a myrtle extract and a fluorine salt for oral application
FR3069778A1 (en) * 2017-08-04 2019-02-08 Pierre Fabre Medicament COMPOSITION COMPRISING MYRT EXTRACT AND FLUORINE SALT FOR ORAL TOXIC APPLICATION

Also Published As

Publication number Publication date
ES450129A1 (en) 1977-11-16
FR2318632B1 (en) 1978-10-06

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