FR2318632A1 - SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries - Google Patents
SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental cariesInfo
- Publication number
- FR2318632A1 FR2318632A1 FR7523715A FR7523715A FR2318632A1 FR 2318632 A1 FR2318632 A1 FR 2318632A1 FR 7523715 A FR7523715 A FR 7523715A FR 7523715 A FR7523715 A FR 7523715A FR 2318632 A1 FR2318632 A1 FR 2318632A1
- Authority
- FR
- France
- Prior art keywords
- substd
- esp
- treating
- useful
- dental caries
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Pyridinium salts of formula (I) are new: (R1 = H or alkyl; R2, at the 2 or 3 posn., is CH2OH, CONH.CH2CH2OH, morpholinocarbonyl or COOR3; R3 = alkyl). They are prepd. by conventional salt formation between R1F and R2-substd. pyridines. (I) are used for treatment or prophylaxis of parodontopathia, dental disease and esp. caries. They are stable in aq. soln., have high ionisation constants, are non-toxic and have good F transport properties. They also strengthen the gums and inhibit formation of plaque and tartar. A specifically claimed cpd., pyrid-3-ylmethanol hydro-fluoride, was prepd. by reacting pyrid-3-ylmethanol with an equiv. of aq. HF.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7523715A FR2318632A1 (en) | 1975-07-25 | 1975-07-25 | SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries |
DE19762633028 DE2633028A1 (en) | 1975-07-25 | 1976-07-22 | PYRIDINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM |
GB3083976A GB1575915A (en) | 1975-07-25 | 1976-07-23 | Pyridine derived fluorides and pharmaceutical compositions containing them |
CH949076A CH598220A5 (en) | 1975-07-25 | 1976-07-23 | |
ES450129A ES450129A1 (en) | 1975-07-25 | 1976-07-24 | Procedure for the preparation of 3-pyridil-methanol fluorhydrate. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7523715A FR2318632A1 (en) | 1975-07-25 | 1975-07-25 | SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2318632A1 true FR2318632A1 (en) | 1977-02-18 |
FR2318632B1 FR2318632B1 (en) | 1978-10-06 |
Family
ID=9158497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7523715A Granted FR2318632A1 (en) | 1975-07-25 | 1975-07-25 | SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries |
Country Status (2)
Country | Link |
---|---|
ES (1) | ES450129A1 (en) |
FR (1) | FR2318632A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534474A1 (en) * | 1982-10-15 | 1984-04-20 | Fabre Sa Pierre | Dentifrice composition |
WO1988008697A1 (en) * | 1987-05-04 | 1988-11-17 | Blendax-Werke R. Schneider Gmbh & Co. | Toothpaste |
FR2915386A1 (en) * | 2007-04-24 | 2008-10-31 | Pierre Fabre Medicament Sa | USE OF AQUEOUS EXTRACT OF GRAPE PEPINS IN ASSOCIATION WITH AT LEAST ONE FLUOR SALT AGAINST THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND THE COMPOSITIONS COMPRISING SAID ASSOCIATION |
WO2019025622A1 (en) | 2017-08-04 | 2019-02-07 | Pierre Fabre Medicament | Composition comprising a myrtle extract and a fluorine salt for oral application |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2660582A (en) * | 1950-06-30 | 1953-11-24 | Cilag Ltd | Quaternary nicotinic acid amide derivatives and production thereof |
FR1297708A (en) * | 1958-05-29 | 1962-07-06 | Gaba Ag | Quaternary ammonium fluorides and their manufacturing processes |
FR2172906A1 (en) * | 1972-02-25 | 1973-10-05 | Fabre Sa Pierre | Salts of 3-pyridyl methanol derivs - vasodilators |
-
1975
- 1975-07-25 FR FR7523715A patent/FR2318632A1/en active Granted
-
1976
- 1976-07-24 ES ES450129A patent/ES450129A1/en not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2660582A (en) * | 1950-06-30 | 1953-11-24 | Cilag Ltd | Quaternary nicotinic acid amide derivatives and production thereof |
FR1297708A (en) * | 1958-05-29 | 1962-07-06 | Gaba Ag | Quaternary ammonium fluorides and their manufacturing processes |
FR2172906A1 (en) * | 1972-02-25 | 1973-10-05 | Fabre Sa Pierre | Salts of 3-pyridyl methanol derivs - vasodilators |
Non-Patent Citations (1)
Title |
---|
ARZNEIMITTELFORSCHUNG, 15, 1965 NO. 12, PAGES 1421-28) * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534474A1 (en) * | 1982-10-15 | 1984-04-20 | Fabre Sa Pierre | Dentifrice composition |
WO1988008697A1 (en) * | 1987-05-04 | 1988-11-17 | Blendax-Werke R. Schneider Gmbh & Co. | Toothpaste |
EP0291747A1 (en) * | 1987-05-04 | 1988-11-23 | Blendax GmbH | Toothpaste |
FR2915386A1 (en) * | 2007-04-24 | 2008-10-31 | Pierre Fabre Medicament Sa | USE OF AQUEOUS EXTRACT OF GRAPE PEPINS IN ASSOCIATION WITH AT LEAST ONE FLUOR SALT AGAINST THE FORMATION OR ACCUMULATION OF DENTAL BIOFILM AND THE COMPOSITIONS COMPRISING SAID ASSOCIATION |
WO2008132149A1 (en) * | 2007-04-24 | 2008-11-06 | Pierre Fabre Medicament | Use of an aqueous grape seed extract combined with at least one fluorine salt to combat the formation or accumulation of dental biofilm and compositions comprising said combination |
WO2019025622A1 (en) | 2017-08-04 | 2019-02-07 | Pierre Fabre Medicament | Composition comprising a myrtle extract and a fluorine salt for oral application |
FR3069778A1 (en) * | 2017-08-04 | 2019-02-08 | Pierre Fabre Medicament | COMPOSITION COMPRISING MYRT EXTRACT AND FLUORINE SALT FOR ORAL TOXIC APPLICATION |
Also Published As
Publication number | Publication date |
---|---|
ES450129A1 (en) | 1977-11-16 |
FR2318632B1 (en) | 1978-10-06 |
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