ES464729A1 - Benzisothiazolon process for preparing same and medical composition containing same - Google Patents

Benzisothiazolon process for preparing same and medical composition containing same

Info

Publication number
ES464729A1
ES464729A1 ES464729A ES464729A ES464729A1 ES 464729 A1 ES464729 A1 ES 464729A1 ES 464729 A ES464729 A ES 464729A ES 464729 A ES464729 A ES 464729A ES 464729 A1 ES464729 A1 ES 464729A1
Authority
ES
Spain
Prior art keywords
aryl
alkyl
opt
same
benzisothiazolon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES464729A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robapharm AG
Original Assignee
Robapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robapharm AG filed Critical Robapharm AG
Publication of ES464729A1 publication Critical patent/ES464729A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Benzisotheriazolones of formula (I) and their acid addn. salts when a basic N is present, are new. In the formula R1 and R2 are H, halo, 1-6C alkyl alkoxy, haloalkyl or alkanoylamino, NO2 or NH2 or together on adjacent C they are 3-6C alkylene or 1-3C oxyalkyleneoxy. X is 1-12C opt. branched alkylene, R3=H 1-6C alkyl, (opt. substD. by aryl or OH), 2-6C alkenyl, aryl or N-heterocyclyl, R4=1-6C alkyl (opt. substd. by aryl or OH), 2-6C alkenyl or aryl, or if R3 is not = H, also N-heterocyclyl. R3 and R4 are not both H or lower alkyl when R1 and R2 at positions 5 and 7 are H or halo, and X is lower alkylene. They are prepd. e.g. by reacting the corresp. N-H cpd. with Q.X.NR3R4(Q=easily eliminated gp. (I) are thrombocyte aggregation inhibitors so are useful for preventing or treating thrombosis in humans or animals. The pref. dose for adult humans is 10-500 mg orally 1-3 times per day. (I) can also be used to conserve blood in vitro, pref. at 0.01-50 mu g/ml.
ES464729A 1976-12-04 1977-12-03 Benzisothiazolon process for preparing same and medical composition containing same Expired ES464729A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5064676 1976-12-04

Publications (1)

Publication Number Publication Date
ES464729A1 true ES464729A1 (en) 1978-09-01

Family

ID=10456767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES464729A Expired ES464729A1 (en) 1976-12-04 1977-12-03 Benzisothiazolon process for preparing same and medical composition containing same

Country Status (12)

Country Link
JP (1) JPS5384969A (en)
AR (1) AR216841A1 (en)
BE (1) BE861326A (en)
DE (1) DE2753391A1 (en)
DK (1) DK539577A (en)
ES (1) ES464729A1 (en)
FR (1) FR2372816A1 (en)
NL (1) NL7713355A (en)
PL (1) PL202595A1 (en)
PT (1) PT67348B (en)
SE (1) SE7713711L (en)
ZA (1) ZA776857B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000254B1 (en) * 1977-06-20 1981-06-10 Beecham Group Plc Antithrombotic 2-(gamma-(1-piperidinyl)propyl)1,2-benzisothiazol 3-one, its pharmaceutically acceptable acid addition salts, their preparation and their compositions
JPS58177915A (en) * 1982-04-12 1983-10-18 Green Cross Corp:The Antithrombotic agent
GB9626570D0 (en) * 1996-12-20 1997-02-05 Zeneca Ltd Process for making benzisothiazolin-3-ones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1147947B (en) * 1961-07-25 1963-05-02 Knoll Ag Process for the preparation of new 1,2-benzisothiazolones

Also Published As

Publication number Publication date
PT67348B (en) 1979-04-26
SE7713711L (en) 1978-06-05
JPS5384969A (en) 1978-07-26
ZA776857B (en) 1978-09-27
PL202595A1 (en) 1978-10-09
AR216841A1 (en) 1980-01-31
BE861326A (en) 1978-05-29
FR2372816A1 (en) 1978-06-30
DK539577A (en) 1978-06-05
PT67348A (en) 1977-12-01
DE2753391A1 (en) 1978-06-08
NL7713355A (en) 1978-06-06

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