FR2330394A2 - SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries - Google Patents

SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Info

Publication number
FR2330394A2
FR2330394A2 FR7533893A FR7533893A FR2330394A2 FR 2330394 A2 FR2330394 A2 FR 2330394A2 FR 7533893 A FR7533893 A FR 7533893A FR 7533893 A FR7533893 A FR 7533893A FR 2330394 A2 FR2330394 A2 FR 2330394A2
Authority
FR
France
Prior art keywords
substd
esp
treating
useful
dental caries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7533893A
Other languages
French (fr)
Other versions
FR2330394B2 (en
Inventor
Jacques Dubois
Henri Cousse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Priority to FR7533893A priority Critical patent/FR2330394A2/en
Priority to DE19762633028 priority patent/DE2633028A1/en
Priority to GB3083976A priority patent/GB1575915A/en
Priority to CH949076A priority patent/CH598220A5/xx
Publication of FR2330394A2 publication Critical patent/FR2330394A2/en
Application granted granted Critical
Publication of FR2330394B2 publication Critical patent/FR2330394B2/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Pyridinium salts of formula (I) are new: (R1 = H or alkyl; R2, at the 2 or 3 posn., is CH2OH, CONH.CH2CH2OH, morpholinocarbonyl or COOR3; R3 = alkyl). They are prepd. by conventional salt formation between R1F and R2-substd. pyridines. (I) are used for treatment or prophylaxis of parodontopathia, dental disease and esp. caries. They are stable in aq. soln., have high ionisation constants, are non-toxic and have good F transport properties. They also strengthen the gums and inhibit formation of plaque and tartar. A specifically claimed cpd., pyrid-3-ylmethanol hydro-fluoride, was prepd. by reacting pyrid-3-ylmethanol with an equiv. of aq. HF.
FR7533893A 1975-07-25 1975-11-04 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries Granted FR2330394A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7533893A FR2330394A2 (en) 1975-11-04 1975-11-04 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries
DE19762633028 DE2633028A1 (en) 1975-07-25 1976-07-22 PYRIDINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM
GB3083976A GB1575915A (en) 1975-07-25 1976-07-23 Pyridine derived fluorides and pharmaceutical compositions containing them
CH949076A CH598220A5 (en) 1975-07-25 1976-07-23

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7533893A FR2330394A2 (en) 1975-11-04 1975-11-04 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Publications (2)

Publication Number Publication Date
FR2330394A2 true FR2330394A2 (en) 1977-06-03
FR2330394B2 FR2330394B2 (en) 1983-02-18

Family

ID=9162093

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7533893A Granted FR2330394A2 (en) 1975-07-25 1975-11-04 SUBSTD. PYRIDINIUM FLUORIDE SALTS - esp. useful for treating and preventing dental caries

Country Status (1)

Country Link
FR (1) FR2330394A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534474A1 (en) * 1982-10-15 1984-04-20 Fabre Sa Pierre Dentifrice composition
EP0271455A1 (en) * 1986-11-18 1988-06-15 S. APOLLONIA CORPORATION S.r.L. Fluoride containing collutory for caries prevention

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534474A1 (en) * 1982-10-15 1984-04-20 Fabre Sa Pierre Dentifrice composition
EP0271455A1 (en) * 1986-11-18 1988-06-15 S. APOLLONIA CORPORATION S.r.L. Fluoride containing collutory for caries prevention

Also Published As

Publication number Publication date
FR2330394B2 (en) 1983-02-18

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