FR2317919A1 - Melanges contenant des l-aminoacides et des hydroxy- et/ou ceto-acides, et leur utilisation therapeutique - Google Patents
Melanges contenant des l-aminoacides et des hydroxy- et/ou ceto-acides, et leur utilisation therapeutiqueInfo
- Publication number
- FR2317919A1 FR2317919A1 FR7620328A FR7620328A FR2317919A1 FR 2317919 A1 FR2317919 A1 FR 2317919A1 FR 7620328 A FR7620328 A FR 7620328A FR 7620328 A FR7620328 A FR 7620328A FR 2317919 A1 FR2317919 A1 FR 2317919A1
- Authority
- FR
- France
- Prior art keywords
- hydroxy
- mmoles
- keto
- mixts
- liver disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 title abstract 2
- 125000000468 ketone group Chemical group 0.000 title abstract 2
- 210000003734 kidney Anatomy 0.000 title abstract 2
- 208000017169 kidney disease Diseases 0.000 title abstract 2
- 201000006370 kidney failure Diseases 0.000 title abstract 2
- 208000019423 liver disease Diseases 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- HJEXNFCNNXWHLC-YFKPBYRVSA-N (2s)-2-(hydroxyamino)-4-methylpentanoic acid Chemical compound CC(C)C[C@H](NO)C(O)=O HJEXNFCNNXWHLC-YFKPBYRVSA-N 0.000 abstract 1
- KFSJYZYQSZKRRQ-BYPYZUCNSA-N (2s)-2-(hydroxyamino)-4-methylsulfanylbutanoic acid Chemical compound CSCC[C@H](NO)C(O)=O KFSJYZYQSZKRRQ-BYPYZUCNSA-N 0.000 abstract 1
- KEZFYWVVZILTMW-QMMMGPOBSA-N (2s)-2-nitroso-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N=O)CC1=CC=CC=C1 KEZFYWVVZILTMW-QMMMGPOBSA-N 0.000 abstract 1
- MBGQSVGJHSCMFS-BYPYZUCNSA-N (2s)-3-methyl-2-nitrosobutanoic acid Chemical compound CC(C)[C@H](N=O)C(O)=O MBGQSVGJHSCMFS-BYPYZUCNSA-N 0.000 abstract 1
- MNNSCZMJIYYESW-BYPYZUCNSA-N (2s)-4-methylsulfanyl-2-nitrosobutanoic acid Chemical compound CSCC[C@H](N=O)C(O)=O MNNSCZMJIYYESW-BYPYZUCNSA-N 0.000 abstract 1
- OSCCDBFHNMXNME-YUPRTTJUSA-N (4S)-4-hydroxy-L-isoleucine zwitterion Chemical compound C[C@H](O)[C@H](C)[C@H](N)C(O)=O OSCCDBFHNMXNME-YUPRTTJUSA-N 0.000 abstract 1
- JVQYSWDUAOAHFM-UHFFFAOYSA-N 3-methyl-2-oxovaleric acid Chemical compound CCC(C)C(=O)C(O)=O JVQYSWDUAOAHFM-UHFFFAOYSA-N 0.000 abstract 1
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 abstract 1
- 208000010444 Acidosis Diseases 0.000 abstract 1
- 208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 235000019766 L-Lysine Nutrition 0.000 abstract 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 208000033626 Renal failure acute Diseases 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 230000007950 acidosis Effects 0.000 abstract 1
- 208000026545 acidosis disease Diseases 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 230000007882 cirrhosis Effects 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
- 230000022558 protein metabolic process Effects 0.000 abstract 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 abstract 1
- 229960002898 threonine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752531299 DE2531299A1 (de) | 1975-07-12 | 1975-07-12 | L-amino- und hydroxy- und/oder ketosaeuren enthaltende gemische fuer parenterale oder orale anwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2317919A1 true FR2317919A1 (fr) | 1977-02-11 |
| FR2317919B1 FR2317919B1 (enrdf_load_stackoverflow) | 1978-11-03 |
Family
ID=5951420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7620328A Granted FR2317919A1 (fr) | 1975-07-12 | 1976-07-02 | Melanges contenant des l-aminoacides et des hydroxy- et/ou ceto-acides, et leur utilisation therapeutique |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE2531299A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2317919A1 (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2556593A1 (fr) * | 1983-12-20 | 1985-06-21 | Synthelabo | Composition nutritive contenant de l'acide alpha-cetoisocaproique, de la leucine et des acides amines essentiels et non essentiels |
| FR2880345A1 (fr) * | 2004-12-30 | 2006-07-07 | Adisseo Ireland Ltd | Synthese et applications de l'acide 2-oxo-4-methylthiobutyrique, ses tels et ses derives |
| WO2008122473A3 (en) * | 2007-04-04 | 2009-04-23 | Evonik Degussa Gmbh | Food supplement containing alpha-keto acids |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3936319C3 (de) * | 1989-11-01 | 1997-05-07 | Bartz Volker | Phosphatbinder zur oralen Verabreichung |
| DE3940052A1 (de) * | 1989-12-04 | 1991-06-06 | Nephro Medica Pharma | Dialysier- und spuelloesung zur intraperitonealen verabreichung |
| DE3943424A1 (de) * | 1989-12-30 | 1991-07-04 | Nephro Medica Pharma | Infusions- und injektionsloesung zur intravenoesen verabreichung |
| DE19528524C2 (de) * | 1995-08-03 | 1999-11-11 | Hans Dietl | Calciumhaltiges Mittel zur intestinalen Phosphatbindung und Verfahren zu seiner Herstellung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2335215B2 (de) * | 1972-07-13 | 1979-04-05 | The Johns Hopkins University, Baltimore, Md. (V.St.A.) | Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen |
| GB1442154A (en) * | 1973-04-30 | 1976-07-07 | Walser M | Composition for promotion of protein synthesis and suppression of urea formation in the body |
| DE2516027A1 (de) * | 1973-04-30 | 1975-10-16 | Univ Johns Hopkins | Arzneimittel zur foerderung der proteinsynthese und zur konservierung des stickstoffs im koerper |
-
1975
- 1975-07-12 DE DE19752531299 patent/DE2531299A1/de active Granted
-
1976
- 1976-07-02 FR FR7620328A patent/FR2317919A1/fr active Granted
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2556593A1 (fr) * | 1983-12-20 | 1985-06-21 | Synthelabo | Composition nutritive contenant de l'acide alpha-cetoisocaproique, de la leucine et des acides amines essentiels et non essentiels |
| EP0146474A3 (fr) * | 1983-12-20 | 1985-07-31 | Synthelabo | Composition nutritive contenant de l'acide alpha-cétoisocaproique ou un de ses sels |
| FR2880345A1 (fr) * | 2004-12-30 | 2006-07-07 | Adisseo Ireland Ltd | Synthese et applications de l'acide 2-oxo-4-methylthiobutyrique, ses tels et ses derives |
| WO2006072711A1 (fr) * | 2004-12-30 | 2006-07-13 | Adisseo Ireland Limited | Synthese et applications de l'acide 2-oxo-4-methylthiobutyrique, ses sels et ses derives |
| US7662997B2 (en) | 2004-12-30 | 2010-02-16 | Adisseo Ireland Limited | Synthesis and applications of 2-oxo-4-methylthiobutyric acid, its salts and its derivatives |
| RU2385862C2 (ru) * | 2004-12-30 | 2010-04-10 | АДИССЕО Иэлэнд Лимитэд | Синтез и применение 2-оксо-4-метилтиобутановой кислоты, ее солей и производных |
| EP2229821A3 (fr) * | 2004-12-30 | 2010-11-03 | Adisseo Ireland Limited | L'acide 2-oxo-4-méthylthiobutyrique et ses dérivés comme complément alimentaire |
| WO2008122473A3 (en) * | 2007-04-04 | 2009-04-23 | Evonik Degussa Gmbh | Food supplement containing alpha-keto acids |
| WO2008122613A3 (de) * | 2007-04-04 | 2009-06-04 | Evonik Degussa Gmbh | Nahrungsergänzungsmittel enthaltend alpha-ketosäuren |
| RU2492705C2 (ru) * | 2007-04-04 | 2013-09-20 | Эвоник Дегусса Гмбх | ПИЩЕВАЯ ДОБАВКА, СОДЕРЖАЩАЯ α-КЕТОКИСЛОТЫ |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2531299C2 (enrdf_load_stackoverflow) | 1988-01-14 |
| FR2317919B1 (enrdf_load_stackoverflow) | 1978-11-03 |
| DE2531299A1 (de) | 1977-01-13 |
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