WO2008122473A3 - Food supplement containing alpha-keto acids - Google Patents

Food supplement containing alpha-keto acids Download PDF

Info

Publication number
WO2008122473A3
WO2008122473A3 PCT/EP2008/052724 EP2008052724W WO2008122473A3 WO 2008122473 A3 WO2008122473 A3 WO 2008122473A3 EP 2008052724 W EP2008052724 W EP 2008052724W WO 2008122473 A3 WO2008122473 A3 WO 2008122473A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
food supplement
nitrogen
keto
keto acids
Prior art date
Application number
PCT/EP2008/052724
Other languages
French (fr)
Other versions
WO2008122473A2 (en
Inventor
Andreas Karau
Matthias Kottenhahn
Karlheinz Drauz
Norbert Windhab
Adolf Gruenert
Original Assignee
Evonik Degussa Gmbh
Andreas Karau
Matthias Kottenhahn
Karlheinz Drauz
Norbert Windhab
Adolf Gruenert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Degussa Gmbh, Andreas Karau, Matthias Kottenhahn, Karlheinz Drauz, Norbert Windhab, Adolf Gruenert filed Critical Evonik Degussa Gmbh
Priority to EP08717471A priority Critical patent/EP2175747A2/en
Publication of WO2008122473A2 publication Critical patent/WO2008122473A2/en
Publication of WO2008122473A3 publication Critical patent/WO2008122473A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The invention relates to a food supplement which can contain at least one amino acid, wherein the food supplement is otherwise essentially nitrogen-free and contains at least one alpha-keto acid selected from the group alpha-ketoisocaproate, alpha-ketoisovalerate and alpha-keto-beta-methylvalerate and/or a salt of these alpha-keto acids. The food supplements described support muscle build-up and simultaneously relieve metabolism in nitrogen detoxification by reduced nitrogen supply and improve nitrogen retention in the body.
PCT/EP2008/052724 2007-04-04 2008-03-06 Food supplement containing alpha-keto acids WO2008122473A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08717471A EP2175747A2 (en) 2007-04-04 2008-03-06 Food supplement containing alpha-keto acids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007016715.8 2007-04-04
DE102007016715A DE102007016715A1 (en) 2007-04-04 2007-04-04 Nutritional supplement containing alpha-keto acids

Publications (2)

Publication Number Publication Date
WO2008122473A2 WO2008122473A2 (en) 2008-10-16
WO2008122473A3 true WO2008122473A3 (en) 2009-04-23

Family

ID=39735379

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP2008/052724 WO2008122473A2 (en) 2007-04-04 2008-03-06 Food supplement containing alpha-keto acids
PCT/EP2008/054103 WO2008122613A2 (en) 2007-04-04 2008-04-04 Food supplement containing alpha-keto acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/054103 WO2008122613A2 (en) 2007-04-04 2008-04-04 Food supplement containing alpha-keto acids

Country Status (6)

Country Link
EP (2) EP2175747A2 (en)
CN (1) CN101646358B (en)
BR (1) BRPI0810099A2 (en)
DE (1) DE102007016715A1 (en)
RU (1) RU2492705C2 (en)
WO (2) WO2008122473A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009016119A1 (en) * 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nutritional supplement containing alpha-keto acids to support diabetes therapy
CN102459621B (en) 2009-06-05 2015-01-28 赢创德固赛有限公司 A method for the preparation of 2-keto carboxylic acid
CN102018704B (en) * 2009-09-23 2012-02-22 北京万生药业有限责任公司 Compound preparation used for treating chronic kidney diseases and preparation method thereof
CN101975827A (en) * 2010-09-06 2011-02-16 江南大学 Detection method of alpha-ketoisocaproate content
CN106963749A (en) * 2017-03-23 2017-07-21 华南农业大学 Alpha Ketoglutarate（Salt）Application in terms of antifatigue and improve muscular movement strength
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients
EP3716966A4 (en) 2017-11-29 2021-08-18 Hull, Edgar, L., Jr. Alpha keto acid compositions for treating hypo-albuminemia
ES2882278T3 (en) 2018-07-31 2021-12-01 Evonik Operations Gmbh Branched Chain Keto Acid Mixtures (BCKA) and Procedure for the Production of Such Mixtures
CN109011464B (en) * 2018-08-08 2020-06-05 南通市多乾新材料科技有限公司 A trainer that is used for basketball attack to confront with a kick
EP3797766A1 (en) 2019-09-24 2021-03-31 Evonik Operations GmbH Compositions for use in reducing inflammation

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2315916A2 (en) * 1976-03-23 1977-01-28 Univ Johns Hopkins THERAPEUTIC MIXTURES INCLUDING ANALOGUES ALPHA HYDROXY ACIDS OF ESSENTIAL AMINO ACIDS AND THEIR ADMINISTRATION TO HUMANS FOR THE IMPROVEMENT OF PROTEIN SYNTHESIS AND THE SUPPRESSION OF UREA FORMATION
FR2317919A1 (en) * 1975-07-12 1977-02-11 Fresenius Chem Pharm Ind Amino acid mixts. contg. hydroxy or keto analogues - for treating kidney and liver disorders
US4100161A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
DE2759133A1 (en) * 1976-12-31 1978-07-13 Carmelo Prof Giordano Aminoacid and keto acid mixtures - used as diet additives and for treating e.g. uraemia and hyperazotaemia
EP0146474A2 (en) * 1983-12-20 1985-06-26 Synthelabo Nutritional composition containing alpha-cetoisocaproic acid or one of its salts
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US6100287A (en) * 1997-11-13 2000-08-08 University Of Florida Materials and methods for enhancing muscle performance and recovery from fatigue
WO2003084351A1 (en) * 2002-04-05 2003-10-16 Bioghurt Biogarde Gmbh & Co. Kg Use of creatine pyruvate for increasing stamina during highly intensive intermittent physical exertion
WO2006062424A2 (en) * 2004-11-08 2006-06-15 Sgp & Sons Ab Use of 3-hydroxy-3-methylbutyrate alone or in combination with alpha-ketoglutarate in the growth and mineralisation of the osteo-skeletal system
EP1754415A1 (en) * 2005-08-18 2007-02-21 Gakic Formulations Ltd. Supplemental dietary composition for enhancing muscle performance and/or recovery from fatigue
WO2007064618A1 (en) * 2005-11-30 2007-06-07 Nestec S.A. Methods for the treatment of muscle loss
WO2008049984A2 (en) * 2006-10-17 2008-05-02 Universite Rene Descartes-Paris 5 Use of citrulline for treating undernutrition conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462463B (en) * 1988-12-02 1990-07-02 Decken Alexandra V D FOOD AND FEED CONTAINING KETOS ACIDS

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100161A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Promotion of protein synthesis and suppression of urea formation in the body by keto analogs of essential amino acids
FR2317919A1 (en) * 1975-07-12 1977-02-11 Fresenius Chem Pharm Ind Amino acid mixts. contg. hydroxy or keto analogues - for treating kidney and liver disorders
FR2315916A2 (en) * 1976-03-23 1977-01-28 Univ Johns Hopkins THERAPEUTIC MIXTURES INCLUDING ANALOGUES ALPHA HYDROXY ACIDS OF ESSENTIAL AMINO ACIDS AND THEIR ADMINISTRATION TO HUMANS FOR THE IMPROVEMENT OF PROTEIN SYNTHESIS AND THE SUPPRESSION OF UREA FORMATION
DE2759133A1 (en) * 1976-12-31 1978-07-13 Carmelo Prof Giordano Aminoacid and keto acid mixtures - used as diet additives and for treating e.g. uraemia and hyperazotaemia
EP0146474A2 (en) * 1983-12-20 1985-06-26 Synthelabo Nutritional composition containing alpha-cetoisocaproic acid or one of its salts
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US6100287A (en) * 1997-11-13 2000-08-08 University Of Florida Materials and methods for enhancing muscle performance and recovery from fatigue
WO2003084351A1 (en) * 2002-04-05 2003-10-16 Bioghurt Biogarde Gmbh & Co. Kg Use of creatine pyruvate for increasing stamina during highly intensive intermittent physical exertion
WO2006062424A2 (en) * 2004-11-08 2006-06-15 Sgp & Sons Ab Use of 3-hydroxy-3-methylbutyrate alone or in combination with alpha-ketoglutarate in the growth and mineralisation of the osteo-skeletal system
EP1754415A1 (en) * 2005-08-18 2007-02-21 Gakic Formulations Ltd. Supplemental dietary composition for enhancing muscle performance and/or recovery from fatigue
WO2007064618A1 (en) * 2005-11-30 2007-06-07 Nestec S.A. Methods for the treatment of muscle loss
WO2008049984A2 (en) * 2006-10-17 2008-05-02 Universite Rene Descartes-Paris 5 Use of citrulline for treating undernutrition conditions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
VAN SOMEREN AT AL.: "Supplementation with HMB and alpha-ketoisocaproic acid reduces signs and symptoms of exercise-induced muscle damage in man", INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, vol. 15, no. 4, August 2005 (2005-08-01), US, pages 413 - 424, XP008102825 *

Also Published As

Publication number Publication date
DE102007016715A1 (en) 2008-10-09
CN101646358B (en) 2013-05-29
WO2008122473A2 (en) 2008-10-16
BRPI0810099A2 (en) 2014-09-23
RU2492705C2 (en) 2013-09-20
WO2008122613A3 (en) 2009-06-04
WO2008122613A2 (en) 2008-10-16
EP2175747A2 (en) 2010-04-21
EP2129241A2 (en) 2009-12-09
RU2009140373A (en) 2011-06-20
CN101646358A (en) 2010-02-10

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