FR2306683A1 - Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine - Google Patents

Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine

Info

Publication number
FR2306683A1
FR2306683A1 FR7610309A FR7610309A FR2306683A1 FR 2306683 A1 FR2306683 A1 FR 2306683A1 FR 7610309 A FR7610309 A FR 7610309A FR 7610309 A FR7610309 A FR 7610309A FR 2306683 A1 FR2306683 A1 FR 2306683A1
Authority
FR
France
Prior art keywords
substd
aryl
opt
alkylmercapto
alkylsulphonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7610309A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19752515146 external-priority patent/DE2515146A1/en
Priority claimed from DE19752551483 external-priority patent/DE2551483A1/en
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2306683A1 publication Critical patent/FR2306683A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/38—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/25—Aminoacetonitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
    • C07C317/40—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New carboxamides of formula (I): (where R1-3=same or different, saturated or unsaturated, straight branched or cyclic hydrocarbyl the carbon chain of which may be interrupted by heteroatoms or divalent groups e.g. O,S, -SO-, -SO2-, -CO- or phenylene and may be substituted by substituents such as halo, alkoxy, acyloxy, aryl, aryloxy, arylmercapto, aroyl, alkylmercapto, alkylsulphenyl, alkylsulphonyl, acylamino, aroylamino, cyano, alkoxycarbonyl, aryloxycarbonyl or carbamoyl (opt. substd. by alkyl); R4,R5=same or different H, opt. substd. aryl or saturated or unsaturated, straight, branched or cyclic hydrocarbyl the carbon chain of which is opt. interrupted by heteroatoms or groups such as O,S,SO2,SO,CO and phenylene and may be substd. by hydroxy, alkoxy, halo, acyloxy, acylamino, aryl, aryloxy, aroyl, alkylmercapto, alkylsulphonyl, alkylsulphinyl, cyano, alkoxycarbonyl, aryloxycarbonyl or carbamoul (opt. substd. by alkyl or aryl) radicals or R4 and R5 together may form an alkylene chain; when n=0, R4 and R5 together = alkylene thus form a heterocyclic containing the two N atoms; X=saturated or unsaturated, straight, branched or cyclic hydrocarbon chain which may be interrupted by heteroatoms or groups such as O,S,SO,SO2, arylaza, alkylaza, carbonyl or phenylene and may be substd. by halo, alkoxy, aryloxy, hydroxy, cyano, carboxy, carbalkoxy, acylamino, carbaryloxy, alkylmercapto, alkylsulphinyl, alkylsulphonyl, arylmercapto, aryl or carbamoyl (opt. substd. by alkyl or aryl), radicals and n=0-4. All aryl radicals defined in R1-5 and X have 6-10C atoms and are opt. substd. (I) are hypolipemics which reduce hyperlipemia and the absorption of cholesterol and is administered orally, parenthelly or rectally in the treatment of lipid metabolism troubles e.g. adiposity and hyperlipoproteinemia. The cpds. have low toxicity oral LD50 in mice >2000mg/kg.
FR7610309A 1975-04-08 1976-04-08 Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine Withdrawn FR2306683A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19752515146 DE2515146A1 (en) 1975-04-08 1975-04-08 Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine
DE19752551483 DE2551483A1 (en) 1975-11-17 1975-11-17 Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine

Publications (1)

Publication Number Publication Date
FR2306683A1 true FR2306683A1 (en) 1976-11-05

Family

ID=25768727

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7610309A Withdrawn FR2306683A1 (en) 1975-04-08 1976-04-08 Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine

Country Status (11)

Country Link
JP (1) JPS51127002A (en)
AU (1) AU1271476A (en)
DK (1) DK164176A (en)
FI (1) FI760919A (en)
FR (1) FR2306683A1 (en)
IL (1) IL49352A0 (en)
LU (1) LU74709A1 (en)
NL (1) NL7603594A (en)
NO (1) NO761050L (en)
PT (1) PT64980B (en)
SE (1) SE7602707L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376819A1 (en) * 1988-12-22 1990-07-04 Roussel-Uclaf Acrylated polyamines, process for their preparation and their use as fungicides
EP0385452A1 (en) * 1989-03-03 1990-09-05 Willi Möller AG Carboxylic acid amides which form lipophilic complexes with magnesium ions, method for preparation of the lipophilic magnesium complexes and ion selective components

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU708115B2 (en) * 1991-10-04 1999-07-29 Sloan-Kettering Institute For Cancer Research Novel potent inducers of terminal differentiation and methods of use thereof
TWI238068B (en) 2001-03-06 2005-08-21 Kao Corp Composition for external application
GB0425556D0 (en) * 2004-11-19 2004-12-22 Glaxo Group Ltd Novel compounds
JP5406870B2 (en) * 2010-03-11 2014-02-05 株式会社クラレ Cross-linking agent, cross-linkable composition, cross-linked product, compound and method for producing the same
KR101187064B1 (en) * 2010-07-18 2012-09-28 주식회사 바이오폴리메드 Cationic lipid, method for manufacturing the same and delivery system comprising the same
DE102011080131A1 (en) 2011-07-29 2013-01-31 Evonik Degussa Gmbh Low molecular weight products, and their use as reversible or permanent low temperature crosslinkers in Diels-Alder reactions
WO2014148136A1 (en) * 2013-03-19 2014-09-25 岐阜市 Compound having anti-allergic activity and use of same
WO2018198523A1 (en) * 2017-04-28 2018-11-01 味の素株式会社 N-acylamino acid derivative

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0376819A1 (en) * 1988-12-22 1990-07-04 Roussel-Uclaf Acrylated polyamines, process for their preparation and their use as fungicides
FR2642422A1 (en) * 1988-12-22 1990-08-03 Roussel Uclaf NOVEL ACYLATED POLYAMINES, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS FUNGICIDES
EP0385452A1 (en) * 1989-03-03 1990-09-05 Willi Möller AG Carboxylic acid amides which form lipophilic complexes with magnesium ions, method for preparation of the lipophilic magnesium complexes and ion selective components

Also Published As

Publication number Publication date
NO761050L (en) 1976-10-11
SE7602707L (en) 1976-10-09
DK164176A (en) 1976-10-09
AU1271476A (en) 1977-10-13
IL49352A0 (en) 1976-06-30
LU74709A1 (en) 1977-02-02
FI760919A (en) 1976-10-09
JPS51127002A (en) 1976-11-05
PT64980A (en) 1976-05-01
NL7603594A (en) 1976-10-12
PT64980B (en) 1977-09-07

Similar Documents

Publication Publication Date Title
DK0483772T3 (en) Aminocumaran derivatives, and their preparation and use
FR2306683A1 (en) Hypolipemic carboxylic-amides - such as N-isovaleryl N,N'-bis-(10-undecenoyl) ethylene-diamine
ES464360A1 (en) Process for the production of polybutadiene
FR2362839A1 (en) HYDANTOIN DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING SUCH SUBSTANCES
FR2363329A1 (en) 4-Carbamoyl-5-hydroxy-imidazole - used to treat cancer, nephritis and rheumatism
ES407203A1 (en) Cyclic urea derivatives and salts thereof
ATE99942T1 (en) DEHYDROCHOLECALCIFEROL DERIVATIVES.
SE7709913L (en) WAY TO PRODUCE PENTA PEPTIDER
GB1410516A (en) Phenoxy-carboxylic acid amides
FR2361361A1 (en) NEW DERIVATIVES OF CYCLOPENTANE AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
GB1436226A (en) Heterocyclic fused-ring derivatives of tetrahydronaphthalene and related compounds
ATE12768T1 (en) MEDICATIONS CONTAINING N-ACYL-L-ASPACTYL-TAURINE.
ES482591A1 (en) N-Arylsulfonyl pyrroles, their preparation and medicaments containing them.
ES372209A1 (en) Alpha-{8 (phenyl sulfinyl)methyl{9 -alpha-phenyl derivatives of pyridinemethanols
GB1534242A (en) Derivatives of 2-imino-4-thiazolines and thiazolidines
WO1987001114A3 (en) New amines, process for their manufacture, their use and medicines containing them
JPS5327700A (en) Stickablity of evaporated polymer to substrate having been improved by treatment of gaseous coupling agent
DE3673129D1 (en) ALKYLCARBONIC ACID AMIDES OF PYRIDINE ALKYLAMINES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS.
ES377679A1 (en) Fungicidal and fungistatic thiocarbonates
ATE30014T1 (en) DERIVATIVES OF 2,2-DIAETHOXYPROPIONIC ACID.
JPS51125389A (en) A process for preparing heterocyclic compovnds
FR2276035A1 (en) Substd-indane-5-carboxylic acids - with antiinflammatory, analgesic and antipyretic activity
GB1461806A (en) Pyridine derivatives
JPS53139450A (en) Elastic surface wave element
SE7607128L (en) METHOD AND COMPOSITION FOR THE OPPRESSION OF CARBON FORMATION IN A DIELECTRIC FLUID

Legal Events

Date Code Title Description
ST Notification of lapse