FR2302994A1 - Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique - Google Patents
Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutiqueInfo
- Publication number
- FR2302994A1 FR2302994A1 FR7507120A FR7507120A FR2302994A1 FR 2302994 A1 FR2302994 A1 FR 2302994A1 FR 7507120 A FR7507120 A FR 7507120A FR 7507120 A FR7507120 A FR 7507120A FR 2302994 A1 FR2302994 A1 FR 2302994A1
- Authority
- FR
- France
- Prior art keywords
- useful
- lactons
- aryl
- preparation
- pharmaceutical industry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 CYCLOPROPANE CARBOXYL ACIDS Chemical class 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- PSMORJXEGALFGQ-UHFFFAOYSA-N 2-(hydroxymethyl)-1-phenylcyclopropane-1-carboxylic acid Chemical compound OCC1CC1(C(O)=O)C1=CC=CC=C1 PSMORJXEGALFGQ-UHFFFAOYSA-N 0.000 abstract 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 abstract 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910018954 NaNH2 Inorganic materials 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000005055 alkyl alkoxy group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000012450 pharmaceutical intermediate Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7507120A FR2302994A1 (fr) | 1975-03-06 | 1975-03-06 | Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7507120A FR2302994A1 (fr) | 1975-03-06 | 1975-03-06 | Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2302994A1 true FR2302994A1 (fr) | 1976-10-01 |
| FR2302994B1 FR2302994B1 (enExample) | 1978-02-03 |
Family
ID=9152239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7507120A Granted FR2302994A1 (fr) | 1975-03-06 | 1975-03-06 | Procede de preparation d'acides aryl-1, hydroxy methyl-2 cyclopropanes carboxyliques et de leurs lactones utiles comme intermediaires de synthese dans l'industrie pharmaceutique |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2302994A1 (enExample) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421875A1 (fr) * | 1978-01-31 | 1979-11-02 | Roussel Uclaf | Alcool benzylique substitue optiquement actif et son procede de preparation |
| US4507318A (en) * | 1981-06-23 | 1985-03-26 | Pierre Fabre S.A. | 1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain |
| FR2740452A1 (fr) * | 1995-10-25 | 1997-04-30 | Pf Medicament | Procede de fabrication de 1-phenyl-2-oxo-3-oxa-bicyclo (3:1:0) hexane |
| FR2743559A1 (fr) * | 1996-01-16 | 1997-07-18 | Pf Medicament | Nouveau procede de preparation de lactones bicycliques |
| WO2005123709A1 (ja) * | 2004-06-16 | 2005-12-29 | Sumitomo Chemical Company, Limited | ２－オキソ－１－フェニル－３－オキサビシクロ[３．１．０］ヘキサンの製造方法 |
| WO2012145234A3 (en) * | 2011-04-21 | 2012-12-13 | Emory University | Cyclopropyl derivatives and methods of use |
| JP2015509939A (ja) * | 2012-02-17 | 2015-04-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | オレキシン−２受容体アンタゴニストの合成において有用な方法および化合物 |
| CN108205043A (zh) * | 2016-12-19 | 2018-06-26 | 成都弘达药业有限公司 | 一种左旋米那普仑中间体有关物质的检测方法 |
-
1975
- 1975-03-06 FR FR7507120A patent/FR2302994A1/fr active Granted
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2421875A1 (fr) * | 1978-01-31 | 1979-11-02 | Roussel Uclaf | Alcool benzylique substitue optiquement actif et son procede de preparation |
| US4507318A (en) * | 1981-06-23 | 1985-03-26 | Pierre Fabre S.A. | 1-Aryl 2-aminomethyl cyclopropane carboxylates (Z) as drugs in the treatment of pain |
| FR2740452A1 (fr) * | 1995-10-25 | 1997-04-30 | Pf Medicament | Procede de fabrication de 1-phenyl-2-oxo-3-oxa-bicyclo (3:1:0) hexane |
| WO1997015563A1 (fr) * | 1995-10-25 | 1997-05-01 | Pierre Fabre Medicament | Procede de fabrication de 1-phenyl-2-oxo-3-oxa-bicyclo (3:1:0) hexane |
| FR2743559A1 (fr) * | 1996-01-16 | 1997-07-18 | Pf Medicament | Nouveau procede de preparation de lactones bicycliques |
| WO1997026256A1 (fr) * | 1996-01-16 | 1997-07-24 | Pierre Fabre Medicament | Nouveau procede de preparation de lactones bicycliques |
| WO2005123709A1 (ja) * | 2004-06-16 | 2005-12-29 | Sumitomo Chemical Company, Limited | ２－オキソ－１－フェニル－３－オキサビシクロ[３．１．０］ヘキサンの製造方法 |
| CN100513402C (zh) * | 2004-06-16 | 2009-07-15 | 住友化学株式会社 | 2-氧代-1-苯基-3-氧杂双环[3.1.0]己烷的制造方法 |
| AU2005254872B2 (en) * | 2004-06-16 | 2011-04-07 | Sumitomo Chemical Company, Limited | Method for producing 2-oxo-1-phenyl-3-oxabicyclo(3.1.0)hexane |
| KR101185278B1 (ko) | 2004-06-16 | 2012-09-21 | 스미또모 가가꾸 가부시키가이샤 | 2-옥소-1-페닐-3-옥사비시클로［3.1.0］헥산의 제조 방법 |
| WO2012145234A3 (en) * | 2011-04-21 | 2012-12-13 | Emory University | Cyclopropyl derivatives and methods of use |
| US10207984B2 (en) | 2011-04-21 | 2019-02-19 | Emory University | Cyclopropyl derivatives and methods of use |
| JP2015509939A (ja) * | 2012-02-17 | 2015-04-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | オレキシン−２受容体アンタゴニストの合成において有用な方法および化合物 |
| US9828336B2 (en) | 2012-02-17 | 2017-11-28 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
| CN108205043A (zh) * | 2016-12-19 | 2018-06-26 | 成都弘达药业有限公司 | 一种左旋米那普仑中间体有关物质的检测方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2302994B1 (enExample) | 1978-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |