FR2300090A1 - Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876) - Google Patents

Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876)

Info

Publication number
FR2300090A1
FR2300090A1 FR7503968A FR7503968A FR2300090A1 FR 2300090 A1 FR2300090 A1 FR 2300090A1 FR 7503968 A FR7503968 A FR 7503968A FR 7503968 A FR7503968 A FR 7503968A FR 2300090 A1 FR2300090 A1 FR 2300090A1
Authority
FR
France
Prior art keywords
formaldehyde
prepn
thiophenes
cyclizing
thieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7503968A
Other languages
French (fr)
Other versions
FR2300090B1 (en
Inventor
Emile Braye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parcor SARL
Original Assignee
Parcor SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parcor SARL filed Critical Parcor SARL
Priority to FR7503968A priority Critical patent/FR2300090A1/en
Priority to GR49763A priority patent/GR58595B/en
Priority to ES444644A priority patent/ES444644A1/en
Priority to AR262031A priority patent/AR211532A1/en
Priority to CH97876A priority patent/CH599217A5/xx
Priority to ZA760474A priority patent/ZA76474B/en
Priority to IL48926A priority patent/IL48926A/en
Priority to NLAANVRAGE7600998,A priority patent/NL181432C/en
Priority to SU762316003A priority patent/SU640665A3/en
Priority to HU76PA1233A priority patent/HU174050B/en
Priority to AT75976A priority patent/AT345831B/en
Priority to DE2604248A priority patent/DE2604248C2/en
Priority to DK46376AA priority patent/DK136653B/en
Priority to MX000897U priority patent/MX3207E/en
Priority to YU267/76A priority patent/YU39610B/en
Priority to CA245,134A priority patent/CA1071630A/en
Priority to DD191118A priority patent/DD122977A5/en
Priority to SE7601247A priority patent/SE421621B/en
Priority to PH18060A priority patent/PH14038A/en
Priority to AU10911/76A priority patent/AU496832B2/en
Priority to PL1976187055A priority patent/PL97671B1/en
Priority to GB477276A priority patent/GB1477990A/en
Priority to JP51012735A priority patent/JPS5931513B2/en
Priority to PT64782A priority patent/PT64782B/en
Priority to BE164136A priority patent/BE838327A/en
Priority to RO7684707A priority patent/RO68148A/en
Publication of FR2300090A1 publication Critical patent/FR2300090A1/en
Priority to US05/775,314 priority patent/US4127580A/en
Application granted granted Critical
Publication of FR2300090B1 publication Critical patent/FR2300090B1/fr
Priority to IT7949198A priority patent/IT7949198A0/en
Priority to JP8975379A priority patent/JPS5533469A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Thienopyridine derivs. of formula (I) (where R1 is opt. substd. alkyl, aryl or aralkyl; and R2 and R3 are H, lower alkyl, aryl or heterocyclyl), e.g. 5-(2-chlorobenzyl-4,5,6,7-tetrahydrothieno 3,2-c pyridine, are prepd. by (a) reacting cpds. of formula (II) (where X is H, an alkali metal or a gp. Mg-Y in which Y is halogen) with a cpd. Hal-SO2-R4 (III) (where Hal is halogen and R4 is opt. substd. alkyl, aryl or aralkyl); (b) reacting the resulting cpd. of formula (IV) with an amine R1-NH2 (V); and (c) cyclising the resulting cpd. of formula (VI) with formaldehyde. (I) are pharmaceuticals.
FR7503968A 1975-02-07 1975-02-07 Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876) Granted FR2300090A1 (en)

Priority Applications (29)

Application Number Priority Date Filing Date Title
FR7503968A FR2300090A1 (en) 1975-02-07 1975-02-07 Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876)
GR49763A GR58595B (en) 1975-02-07 1976-01-13 Preparation method of thieno-pyridines derivatives
ES444644A ES444644A1 (en) 1975-02-07 1976-01-27 Process for the preparation of thieno-pyridine derivatives
AR262031A AR211532A1 (en) 1975-02-07 1976-01-27 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THENOPYRIDINE
CH97876A CH599217A5 (en) 1975-02-07 1976-01-27
ZA760474A ZA76474B (en) 1975-02-07 1976-01-28 Process for the preparation of thienopyridine derivatives
IL48926A IL48926A (en) 1975-02-07 1976-01-28 Preparation of 4,5,6,7-tetrahydrothieno(3,2-c)pyridine derivatives
NLAANVRAGE7600998,A NL181432C (en) 1975-02-07 1976-01-30 PROCESS FOR PREPARING 4,5,6,7-TETRAHYDROTHIENO (3,2-C) PYRIDINE DERIVATIVES.
SU762316003A SU640665A3 (en) 1975-02-07 1976-02-02 Method of obtaining thieno (3,2-c) pyridine derivatives or salts thereof
AT75976A AT345831B (en) 1975-02-07 1976-02-03 PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDROTHIENO (3,2-C) PYRIDINE DERIVATIVES
HU76PA1233A HU174050B (en) 1975-02-07 1976-02-03 Process for preparing thienopyridine derivatives
YU267/76A YU39610B (en) 1975-02-07 1976-02-04 Process for obtaining thieno-pyridine derivatives
DK46376AA DK136653B (en) 1975-02-07 1976-02-04 Process for the preparation of thieno-pyridine derivatives.
MX000897U MX3207E (en) 1975-02-07 1976-02-04 PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF TIENO - PIRIDINA
DE2604248A DE2604248C2 (en) 1975-02-07 1976-02-04 Process for the preparation of thienopyridine derivatives
DD191118A DD122977A5 (en) 1975-02-07 1976-02-05 PROCESS FOR THE PREPARATION OF THIENO-PYRIDINE DERIVATIVES
SE7601247A SE421621B (en) 1975-02-07 1976-02-05 PROCEDURE FOR PREPARING TIENOPYRIDINE DERIVATIVES
PH18060A PH14038A (en) 1975-02-07 1976-02-05 Process for the preparation of thieno pyridine derivatives
CA245,134A CA1071630A (en) 1975-02-07 1976-02-05 Process for the preparation of thienopyridine derivatives
JP51012735A JPS5931513B2 (en) 1975-02-07 1976-02-06 Method for producing thieno-pyridine derivatives
GB477276A GB1477990A (en) 1975-02-07 1976-02-06 Process for the preparation of thieno-pyridine derivatives
AU10911/76A AU496832B2 (en) 1975-02-07 1976-02-06 Process for the preparation of thieno pyridine derivatives
PT64782A PT64782B (en) 1975-02-07 1976-02-06 PROCESS FOR THE PREPARATION OF THIENO-PYRIDINE DERIVATIVES
BE164136A BE838327A (en) 1975-02-07 1976-02-06 PROCESS FOR PREPARATION OF THIENOPYRIDINE DERIVATIVES
RO7684707A RO68148A (en) 1975-02-07 1976-02-06 PROCESS FOR THE PREPARATION OF 4,5,6,7-TETRAHYDRO-THIENO- (3,2-C) -PYRIDINE DERIVATIVES
PL1976187055A PL97671B1 (en) 1975-02-07 1976-02-06 METHOD OF THE PRODUCTION OF THENOPYRIDINE DERIVATIVES
US05/775,314 US4127580A (en) 1975-02-07 1977-03-07 Process for the preparation of thieno-pyridine derivatives
IT7949198A IT7949198A0 (en) 1975-02-07 1979-05-28 PROCEDURE FOR PREPARING THIENO-PYRIDINE DERIVATIVES
JP8975379A JPS5533469A (en) 1975-02-07 1979-07-14 Thiophene derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7503968A FR2300090A1 (en) 1975-02-07 1975-02-07 Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876)

Publications (2)

Publication Number Publication Date
FR2300090A1 true FR2300090A1 (en) 1976-09-03
FR2300090B1 FR2300090B1 (en) 1979-03-16

Family

ID=9150954

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7503968A Granted FR2300090A1 (en) 1975-02-07 1975-02-07 Tetrahydro-thieno-pyridine derivs. prepn. - by cyclizing 2-(2-aminoethyl)thiophenes with formaldehyde (BE060876)

Country Status (4)

Country Link
JP (1) JPS5533469A (en)
BE (1) BE838327A (en)
FR (1) FR2300090A1 (en)
ZA (1) ZA76474B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508453A1 (en) * 1981-06-30 1982-12-31 Sanofi Sa PROCESS FOR THE PREPARATION OF (THIENYL-2) AND THIENYL-3) -2-ETHYLAMINE DERIVATIVES AND PRODUCTS THUS OBTAINED
EP0068979A1 (en) * 1981-06-30 1983-01-05 Elf Sanofi Process for the preparation of (thienyl-2) and (thienyl-3)-2 ethyl amine derivatives, and products so obtained
EP0321349A1 (en) 1987-12-18 1989-06-21 Elf Sanofi Process for the preparation of N-(2-chloro-benzyl)(2-thienyl)-2-ethyl amine
EP0439404A2 (en) * 1990-01-25 1991-07-31 Sanofi Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
EP0522956A2 (en) * 1991-07-08 1993-01-13 Sanofi Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508453A1 (en) * 1981-06-30 1982-12-31 Sanofi Sa PROCESS FOR THE PREPARATION OF (THIENYL-2) AND THIENYL-3) -2-ETHYLAMINE DERIVATIVES AND PRODUCTS THUS OBTAINED
EP0068979A1 (en) * 1981-06-30 1983-01-05 Elf Sanofi Process for the preparation of (thienyl-2) and (thienyl-3)-2 ethyl amine derivatives, and products so obtained
EP0068978A1 (en) * 1981-06-30 1983-01-05 Elf Sanofi Process for the preparation of (thienyl-2)- and (thienyl-3)-2 ethylamine derivatives, and products so obtained
EP0321349A1 (en) 1987-12-18 1989-06-21 Elf Sanofi Process for the preparation of N-(2-chloro-benzyl)(2-thienyl)-2-ethyl amine
FR2624860A1 (en) * 1987-12-18 1989-06-23 Sanofi Sa PROCESS FOR THE PREPARATION OF N- (2-CHLORO-BENZYL) (THIENYL-2) -2 ETHYLAMINE
US4873343A (en) * 1987-12-18 1989-10-10 Sanofi Process for the preparation of N-(2-chlorobenzyl)-2-(2-thienyl) ethylamine
EP0321349B1 (en) * 1987-12-18 1992-04-15 Elf Sanofi Process for the preparation of n-(2-chloro-benzyl)(2-thienyl)-2-ethyl amine
EP0439404A2 (en) * 1990-01-25 1991-07-31 Sanofi Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
EP0439404A3 (en) * 1990-01-25 1992-04-08 Sanofi Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno (3,2-c) pyridine derivatives therefrom
EP0522956A2 (en) * 1991-07-08 1993-01-13 Sanofi Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
EP0522956A3 (en) * 1991-07-08 1993-04-07 Elf Sanofi Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno (3,2-c) pyridine derivatives therefrom

Also Published As

Publication number Publication date
ZA76474B (en) 1977-03-30
FR2300090B1 (en) 1979-03-16
JPS5533469A (en) 1980-03-08
JPS562068B2 (en) 1981-01-17
BE838327A (en) 1976-08-06

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Legal Events

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TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0248, 920521

CA Change of address
CD Change of name or company name
CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0248, 750207

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