FR2299037A2 - Synthetic vincamines and benzoic acid deriv. compsns. - opt. contg. ascorbic acid for treating thrombosis esp. of the brain - Google Patents
Synthetic vincamines and benzoic acid deriv. compsns. - opt. contg. ascorbic acid for treating thrombosis esp. of the brainInfo
- Publication number
- FR2299037A2 FR2299037A2 FR7502485A FR7502485A FR2299037A2 FR 2299037 A2 FR2299037 A2 FR 2299037A2 FR 7502485 A FR7502485 A FR 7502485A FR 7502485 A FR7502485 A FR 7502485A FR 2299037 A2 FR2299037 A2 FR 2299037A2
- Authority
- FR
- France
- Prior art keywords
- compsns
- contg
- alkyl
- esp
- brain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Therapeutic vincamine-type compsns. contg. (i) >=1 cpd. of formulae (I) or (II): (where Z is (a) an ether gp. R.A.O.CH2- where A is 1-5C alkylene; R is the gp. where R1 and R2 are H or 1-5C alkyl; a 5-7 membered N-heterocycle opt. contg. a second heteroatom (O, N or S); a phenyl gp. where R3, R4 and R5 are H, halo, NO2, 1-3C alkyl, 1-3C haloalkyl or 1-3C alkoxy; (b) an ester gp. R6.O2C- where R6 is a 2-10C alkyl R7, or a gp. of formula: where R8 and R9 are H or Me; R10 is 1-4C alkyl or the gp. where m is is 1-5; n is 2-7; or the gp. Z is a gp. of formula: where R11, R12 and R13 are H or Me); (ii) >=1 benzoic acid derivs., namely, salicylamide, 2-acetoxybenzoic acid and its salt esters and amides, and the isomeric diacetoxybenzoic aceds, their salts, esters and amides), are new. The compsns. of cerebral vasodilator (i) and inhibitors of blood platelet aggregation (ii) are partic. for treating thrombotic episodes, esp. in the brain, in man and animals. Addn. of ascorbic acid to the compns. potentiates the activity by increasing the absorption of (I) and (II).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7502485A FR2299037A2 (en) | 1975-01-28 | 1975-01-28 | Synthetic vincamines and benzoic acid deriv. compsns. - opt. contg. ascorbic acid for treating thrombosis esp. of the brain |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7502485A FR2299037A2 (en) | 1975-01-28 | 1975-01-28 | Synthetic vincamines and benzoic acid deriv. compsns. - opt. contg. ascorbic acid for treating thrombosis esp. of the brain |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2299037A2 true FR2299037A2 (en) | 1976-08-27 |
FR2299037B2 FR2299037B2 (en) | 1978-08-25 |
Family
ID=9150362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7502485A Granted FR2299037A2 (en) | 1975-01-28 | 1975-01-28 | Synthetic vincamines and benzoic acid deriv. compsns. - opt. contg. ascorbic acid for treating thrombosis esp. of the brain |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2299037A2 (en) |
-
1975
- 1975-01-28 FR FR7502485A patent/FR2299037A2/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2299037B2 (en) | 1978-08-25 |
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