FR2296420A1 - N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics - Google Patents

N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics

Info

Publication number
FR2296420A1
FR2296420A1 FR7500034A FR7500034A FR2296420A1 FR 2296420 A1 FR2296420 A1 FR 2296420A1 FR 7500034 A FR7500034 A FR 7500034A FR 7500034 A FR7500034 A FR 7500034A FR 2296420 A1 FR2296420 A1 FR 2296420A1
Authority
FR
France
Prior art keywords
antitussives
analgesics
morphinum
sulphoalkyl
addictive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7500034A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to FR7500034A priority Critical patent/FR2296420A1/en
Publication of FR2296420A1 publication Critical patent/FR2296420A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

New morphine derivs. of formula (I): (n=3 or 4), are prepd. from morphine base by reaction in aq. medium with appropriate sultone. (I) are antitussives and analgesics useful for treating respiratory disorders (e.g. rhino-pharyngitis, laryngitis, etc) and pain (e.g. dental, articular or muscular). The i, p. LD50 (animal not specified) is 2,150 mg/kg. c.f. 370 mg/kg for morphine hydrochloride and in mice a dose of 1 g/kg does not cause addiction (as determined by response to a subsequent injection of nalorphine). Proposed human dose is 10-30 mg/day.
FR7500034A 1975-01-02 1975-01-02 N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics Withdrawn FR2296420A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7500034A FR2296420A1 (en) 1975-01-02 1975-01-02 N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7500034A FR2296420A1 (en) 1975-01-02 1975-01-02 N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics

Publications (1)

Publication Number Publication Date
FR2296420A1 true FR2296420A1 (en) 1976-07-30

Family

ID=9149366

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7500034A Withdrawn FR2296420A1 (en) 1975-01-02 1975-01-02 N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics

Country Status (1)

Country Link
FR (1) FR2296420A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1053238A1 (en) * 1998-01-29 2000-11-22 Monash University Therapeutic compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1053238A1 (en) * 1998-01-29 2000-11-22 Monash University Therapeutic compounds
EP1053238A4 (en) * 1998-01-29 2003-09-03 Univ Monash Therapeutic compounds
US6784186B1 (en) 1998-01-29 2004-08-31 Roy W. Jackson Therapeutic compounds

Similar Documents

Publication Publication Date Title
HUT62798A (en) Process for producing pharmaceutical composition with slimming activity
GR3026563T3 (en) Method for the treatment of withdrawal symptoms associated with smoking cessation and preparations for use in said method
MY108261A (en) Water soluble camptothecin derivatives
HU910369D0 (en) Medical preparation
KR920703043A (en) Use of GABA-B selective agonists as antitussives
ES2010561A6 (en) Somatostatin analogue composition and use in treating breast cancer
FR2363329A1 (en) 4-Carbamoyl-5-hydroxy-imidazole - used to treat cancer, nephritis and rheumatism
FR2296420A1 (en) N-sulphoalkyl morphinum inner salts - as non-addictive antitussives and analgesics
US3862946A (en) N-benzyl-N-{8 2-phenyl-2-(4-phenyl-1-piperidyl)ethyl{9 {0 propionamide para-chlorobenzene sulfonate
DE3063339D1 (en) Peptides with pharmacological activity and medicines containing them
NZ233704A (en) Dehydrocholecalciferol derivatives, pharmaceutical compositions thereof
Wright et al. Clinical trial of fluvoxamine: A new serotonergic antidepressant.
Thornhill et al. Tolerance and evidence of physical dependence to daily codeine injections in the rat
DE69525841D1 (en) METHOD AND MEDICINE TO REDUCE THE JET LAG
GB2014141A (en) 8???-ethyl- and 8???-methyl-4,5??? epoxymorphinan-6-one compounds
Schmidt et al. Effect of a calcium chelator on morphine tolerance development
BR9708922A (en) Pyridyl-and pyrimidyl-piperazines in the treatment of diseases caused by substances used in excess
Eddy The history of the development of narcotics
FR2428439A1 (en) Treatment of sexual frigidity or impotence - with opiate antagonists
DE68910010D1 (en) Use of dapiprazole in the manufacture of a medicament for preventing tolerance development in analgesic treatment with morphine.
Harris Narcotic antagonists in the benzomorphan series: Respiratory, cardiovascular and behavioral effects in dogs
Gibson The centenary of Shoma Morita.
FR2117796A6 (en) Vincine derivs - used as antitussives, sedatives local anaesthetics and analgesics
Pozuels Suppression of craving and withdrawal in humans addicted to narcotics or amphetamines by administration of alpha-methyl-para-tyrosine (AMPT) and 5-butylpicolinic acid (fusaric acid) treatment of narcotic and amphetamine addiction in humans: preliminary report
Nurimoto et al. Homobenzomorphan compounds with a potent narcotic antagonist property

Legal Events

Date Code Title Description
ST Notification of lapse