FR2294179A1 - Antibiotic cephalosporin derivs - prepd by treatment of cephalosporin with 5-mercapto-1,2,3-triazole - Google Patents
Antibiotic cephalosporin derivs - prepd by treatment of cephalosporin with 5-mercapto-1,2,3-triazoleInfo
- Publication number
- FR2294179A1 FR2294179A1 FR7538216A FR7538216A FR2294179A1 FR 2294179 A1 FR2294179 A1 FR 2294179A1 FR 7538216 A FR7538216 A FR 7538216A FR 7538216 A FR7538216 A FR 7538216A FR 2294179 A1 FR2294179 A1 FR 2294179A1
- Authority
- FR
- France
- Prior art keywords
- cephalosporin
- formula
- prepd
- triazole
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Cephalosporin derivs. of formula (I) (where X is H, HOOC-CH(NHZ)-(CH2)3-CO-, or D-(-) Z is H or a protecting gp. -OCOR, -CONHR or -COR; R is 1-20C (halo)alkyl or aryl, pref. n is 0-6; R2 and R3 are each H, Cl, Br, F, NO2, lower alkyl or alkoxy are prepd. by (a) treating a cpd. of formula (II) (where M is H or a cation; Y is (III) with a 5-mercapto-1,2,3-triazole of formula (IV) or its salt, to produce a cpd. of formula (V), (b) cleaving the 7-amido gp. on (V) to give 7-amino-3-(5-(1,2,3-triazol-5-yl)thiomethyl)-3-cephem-4-carboxyli- c acid (VI) and (c) opt. acylating (VI) with a deriv. of D-(-) acid (VII) (where B is protecting gp) and eliminating the protecting gp. B. (I) are antibiotics and inters. for antibiotics, active against both Gram positive and negative bacteria.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53266374A | 1974-12-13 | 1974-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2294179A1 true FR2294179A1 (en) | 1976-07-09 |
Family
ID=24122664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7538216A Withdrawn FR2294179A1 (en) | 1974-12-13 | 1975-12-12 | Antibiotic cephalosporin derivs - prepd by treatment of cephalosporin with 5-mercapto-1,2,3-triazole |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JPS6117837B2 (en) |
| AT (1) | AT343803B (en) |
| AU (1) | AU8688075A (en) |
| BE (1) | BE836428A (en) |
| DD (1) | DD123191A5 (en) |
| DE (1) | DE2556105A1 (en) |
| DK (1) | DK564175A (en) |
| ES (1) | ES443372A1 (en) |
| FI (1) | FI753518A (en) |
| FR (1) | FR2294179A1 (en) |
| GR (1) | GR58533B (en) |
| IL (1) | IL48644A0 (en) |
| IN (1) | IN143474B (en) |
| LU (1) | LU74003A1 (en) |
| NL (1) | NL7514391A (en) |
| NO (1) | NO754196L (en) |
| NZ (1) | NZ179268A (en) |
| OA (1) | OA05182A (en) |
| RO (1) | RO68147A (en) |
| SE (1) | SE7514034L (en) |
| ZA (1) | ZA757744B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3819621A (en) * | 1970-12-30 | 1974-06-25 | Fujisawa Pharmaceutical Co | 3-substituted-thiomethyl-3-cephem-4-carboxylic acid derivatives |
| JPS4945879A (en) * | 1972-09-09 | 1974-05-01 | ||
| KR780000197B1 (en) * | 1972-12-26 | 1978-05-26 | Bristol Myers Co | Method for preparing antibacterial agent |
-
1975
- 1975-11-18 NZ NZ179268A patent/NZ179268A/en unknown
- 1975-11-19 IN IN2201/CAL/1975A patent/IN143474B/en unknown
- 1975-11-24 GR GR49447A patent/GR58533B/en unknown
- 1975-11-24 AU AU86880/75A patent/AU8688075A/en not_active Expired
- 1975-12-09 RO RO7584141A patent/RO68147A/en unknown
- 1975-12-09 BE BE162568A patent/BE836428A/en unknown
- 1975-12-10 ES ES443372A patent/ES443372A1/en not_active Expired
- 1975-12-10 IL IL48644A patent/IL48644A0/en unknown
- 1975-12-10 NL NL7514391A patent/NL7514391A/en not_active Application Discontinuation
- 1975-12-10 AT AT938875A patent/AT343803B/en not_active IP Right Cessation
- 1975-12-10 ZA ZA757744A patent/ZA757744B/en unknown
- 1975-12-11 SE SE7514034A patent/SE7514034L/en unknown
- 1975-12-11 NO NO754196A patent/NO754196L/no unknown
- 1975-12-11 DK DK564175A patent/DK564175A/en unknown
- 1975-12-12 OA OA55690A patent/OA05182A/en unknown
- 1975-12-12 DE DE19752556105 patent/DE2556105A1/en active Pending
- 1975-12-12 JP JP50147480A patent/JPS6117837B2/ja not_active Expired
- 1975-12-12 LU LU74003A patent/LU74003A1/xx unknown
- 1975-12-12 FR FR7538216A patent/FR2294179A1/en not_active Withdrawn
- 1975-12-12 FI FI753518A patent/FI753518A/fi not_active Application Discontinuation
- 1975-12-15 DD DD190154A patent/DD123191A5/xx unknown
-
1985
- 1985-04-25 JP JP60087656A patent/JPS615083A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI753518A (en) | 1976-06-14 |
| NZ179268A (en) | 1978-04-28 |
| IL48644A0 (en) | 1976-02-29 |
| SE7514034L (en) | 1976-06-14 |
| NO754196L (en) | 1976-06-15 |
| AU8688075A (en) | 1977-06-02 |
| NL7514391A (en) | 1976-06-15 |
| DD123191A5 (en) | 1976-12-05 |
| IN143474B (en) | 1977-12-03 |
| JPS5182294A (en) | 1976-07-19 |
| LU74003A1 (en) | 1976-11-11 |
| GR58533B (en) | 1977-10-31 |
| AT343803B (en) | 1978-06-26 |
| ATA938875A (en) | 1977-10-15 |
| JPS6117837B2 (en) | 1986-05-09 |
| BE836428A (en) | 1976-06-09 |
| JPS615083A (en) | 1986-01-10 |
| DE2556105A1 (en) | 1976-06-24 |
| RO68147A (en) | 1980-01-15 |
| ES443372A1 (en) | 1977-12-01 |
| ZA757744B (en) | 1976-11-24 |
| DK564175A (en) | 1976-06-14 |
| OA05182A (en) | 1981-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |