FR2284321A1 - Nouveaux derives cycloalkyles de 1-aryloxy-3-amino-2-propanols, leurs procedes de preparation, et leurs utilisations therapeutiques - Google Patents
Nouveaux derives cycloalkyles de 1-aryloxy-3-amino-2-propanols, leurs procedes de preparation, et leurs utilisations therapeutiquesInfo
- Publication number
- FR2284321A1 FR2284321A1 FR7528137A FR7528137A FR2284321A1 FR 2284321 A1 FR2284321 A1 FR 2284321A1 FR 7528137 A FR7528137 A FR 7528137A FR 7528137 A FR7528137 A FR 7528137A FR 2284321 A1 FR2284321 A1 FR 2284321A1
- Authority
- FR
- France
- Prior art keywords
- activity
- aminopropan
- ols
- phenoxy
- arrhythmic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JZEHWMUIAKALDN-UHFFFAOYSA-N 1-amino-3-phenoxypropan-2-ol Chemical class NCC(O)COC1=CC=CC=C1 JZEHWMUIAKALDN-UHFFFAOYSA-N 0.000 title abstract 2
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 230000000747 cardiac effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- -1 1-adamantyl Chemical group 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000004340 exo-2-norbornyl group Chemical group [H]C1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@]1([H])C([H])([H])[C@]2([H])* 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50540874A | 1974-09-12 | 1974-09-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2284321A1 true FR2284321A1 (fr) | 1976-04-09 |
| FR2284321B1 FR2284321B1 (enrdf_load_html_response) | 1978-07-28 |
Family
ID=24010183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7528137A Granted FR2284321A1 (fr) | 1974-09-12 | 1975-09-12 | Nouveaux derives cycloalkyles de 1-aryloxy-3-amino-2-propanols, leurs procedes de preparation, et leurs utilisations therapeutiques |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS51125038A (enrdf_load_html_response) |
| BE (1) | BE833291A (enrdf_load_html_response) |
| DD (1) | DD122519A5 (enrdf_load_html_response) |
| DE (1) | DE2540552A1 (enrdf_load_html_response) |
| DK (1) | DK405775A (enrdf_load_html_response) |
| ES (1) | ES440890A1 (enrdf_load_html_response) |
| FR (1) | FR2284321A1 (enrdf_load_html_response) |
| NL (1) | NL7510781A (enrdf_load_html_response) |
| SE (1) | SE7510153L (enrdf_load_html_response) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2522325A1 (fr) * | 1982-02-26 | 1983-09-02 | Delalande Sa | Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique |
| WO2008130464A1 (en) * | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665094A (en) * | 1985-08-29 | 1987-05-12 | Merck & Co., Inc. | Oculoselective beta-blockers for treatment of elevated intraocular pressure |
| US4945182A (en) * | 1985-12-24 | 1990-07-31 | Merck & Co., Inc. | Oculoselective beta-blockers |
| JP3441665B2 (ja) * | 1999-02-04 | 2003-09-02 | 株式会社資生堂 | （２−置換オキシフェニル）アルカンアミド誘導体及び養毛剤、皮膚外用剤 |
| PL209602B1 (pl) | 2005-10-20 | 2011-09-30 | Inst Chemii Bioorg Pan | Sposób otrzymywania amidu kwasu 3-(4-hydroksyfenylo)propanowego |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1937477A1 (de) * | 1969-07-23 | 1971-02-04 | Boehringer Sohn Ingelheim | Neue 1-Phenoxy-2-hydroxy-3-cycloalkylaminopropane und Verfahren zu ihrer Herstellung |
| GB1391444A (en) * | 1971-07-13 | 1975-04-23 | Ici Ltd | Chemical process for the manufacture of alkanolamine derivatives |
-
1975
- 1975-09-11 BE BE159930A patent/BE833291A/xx unknown
- 1975-09-11 DE DE19752540552 patent/DE2540552A1/de active Pending
- 1975-09-11 SE SE7510153A patent/SE7510153L/xx unknown
- 1975-09-11 DK DK405775A patent/DK405775A/da unknown
- 1975-09-12 DD DD188308A patent/DD122519A5/xx unknown
- 1975-09-12 NL NL7510781A patent/NL7510781A/xx unknown
- 1975-09-12 JP JP50110138A patent/JPS51125038A/ja active Pending
- 1975-09-12 ES ES440890A patent/ES440890A1/es not_active Expired
- 1975-09-12 FR FR7528137A patent/FR2284321A1/fr active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1937477A1 (de) * | 1969-07-23 | 1971-02-04 | Boehringer Sohn Ingelheim | Neue 1-Phenoxy-2-hydroxy-3-cycloalkylaminopropane und Verfahren zu ihrer Herstellung |
| GB1391444A (en) * | 1971-07-13 | 1975-04-23 | Ici Ltd | Chemical process for the manufacture of alkanolamine derivatives |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2522325A1 (fr) * | 1982-02-26 | 1983-09-02 | Delalande Sa | Nouveaux derives aryliques de la piperazine, de l'homopiperazine et de n,n'-dialkyl diamino-1,2 ethane, leur procede de preparation et leur application en therapeutique |
| WO2008130464A1 (en) * | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
| US9371297B2 (en) | 2007-02-09 | 2016-06-21 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
| US9949949B2 (en) | 2007-02-09 | 2018-04-24 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
| US10258602B2 (en) | 2007-02-09 | 2019-04-16 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| DK405775A (da) | 1976-03-13 |
| DD122519A5 (enrdf_load_html_response) | 1976-10-12 |
| NL7510781A (nl) | 1976-03-16 |
| SE7510153L (sv) | 1976-05-07 |
| FR2284321B1 (enrdf_load_html_response) | 1978-07-28 |
| JPS51125038A (en) | 1976-11-01 |
| ES440890A1 (es) | 1977-04-01 |
| BE833291A (fr) | 1976-03-11 |
| DE2540552A1 (de) | 1976-03-25 |
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| Fromm | Excerpt of Mumford, L., 1961: The City in History. Its Origins, Its Transformations, and Its Prospects, New York (Harcourt, Brace & World) 1961. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |