FR2271822A2 - Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria - Google Patents

Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria

Info

Publication number
FR2271822A2
FR2271822A2 FR7417728A FR7417728A FR2271822A2 FR 2271822 A2 FR2271822 A2 FR 2271822A2 FR 7417728 A FR7417728 A FR 7417728A FR 7417728 A FR7417728 A FR 7417728A FR 2271822 A2 FR2271822 A2 FR 2271822A2
Authority
FR
France
Prior art keywords
acyl
oral administration
antibiotic
gps
negative bacteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7417728A
Other languages
French (fr)
Other versions
FR2271822B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to FR7417728A priority Critical patent/FR2271822A2/en
Publication of FR2271822A2 publication Critical patent/FR2271822A2/en
Application granted granted Critical
Publication of FR2271822B2 publication Critical patent/FR2271822B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

(A) Acyl derivs. of antibiotic WS-4545 of formula (I) are new. (in which R1 is acyl and R2 and R3 are H or acyl, the acyl gps. being selected from 2-10C alkanoyl interrupted by an S atom, 2-10C alkenoyl, 3-methoxycarbonyl-propionyl, 3,4,5-trimethoxybenzoyl, 2-(3,4,5-trimethoxy)phenylacetyl, phenylacetyl, p-nitrobenzoyl, phenoxyacetyl, thienylacetyl or tetrahydro-2-thenoyl). (B) (Not claimed). Cpds. of formula (I) in which the acyl gp (S). are derived from aliphatic, aromatic or heterocyclic carboxylic acids. This is an Addition to 773719. (I) are antibiotics partic. effective against Gram negative bacteria, e.g. Escherichia and Salmonella spp. They give higher concns. after oral administration than WS-4545. Urinary excretion of (I) after oral administration to rats is 40.6-73.1% over 24 hrs., whereas for WS-4545 it is 24.1%. The daily dose of (I) is 0.5-5 (pref. 1-2)g. The acyl gps. are 3-vinylpropionyl, 3-methylcrotonyl, methylthioacetyl, ethylthioacetyl, isopropylthioacetyl, 2-methylthiopropionyl; t-butylthioacetyl, 2-t-butylthiopropionyl and the gps. mentioned specifically.
FR7417728A 1974-05-21 1974-05-21 Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria Granted FR2271822A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7417728A FR2271822A2 (en) 1974-05-21 1974-05-21 Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7417728A FR2271822A2 (en) 1974-05-21 1974-05-21 Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria

Publications (2)

Publication Number Publication Date
FR2271822A2 true FR2271822A2 (en) 1975-12-19
FR2271822B2 FR2271822B2 (en) 1978-05-26

Family

ID=9139133

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7417728A Granted FR2271822A2 (en) 1974-05-21 1974-05-21 Acyl derivs of antibiotic WS-4545 - active on oral administration against gram negative bacteria

Country Status (1)

Country Link
FR (1) FR2271822A2 (en)

Also Published As

Publication number Publication date
FR2271822B2 (en) 1978-05-26

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