FR2261754A1 - 4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents - Google Patents

4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents

Info

Publication number
FR2261754A1
FR2261754A1 FR7406084A FR7406084A FR2261754A1 FR 2261754 A1 FR2261754 A1 FR 2261754A1 FR 7406084 A FR7406084 A FR 7406084A FR 7406084 A FR7406084 A FR 7406084A FR 2261754 A1 FR2261754 A1 FR 2261754A1
Authority
FR
France
Prior art keywords
disubstd
diuretic
antiinflammatory
salidiuretic
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7406084A
Other languages
French (fr)
Other versions
FR2261754B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to FR7406084A priority Critical patent/FR2261754A1/en
Publication of FR2261754A1 publication Critical patent/FR2261754A1/en
Application granted granted Critical
Publication of FR2261754B1 publication Critical patent/FR2261754B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
    • C07C37/16—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester group derived therefrom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain

Abstract

Title cpds. of formula (I) (where X1 is 1-7C alkyl or 5-6C cycloalkyl and X2 is Hal3C) are prepd. either by hydrolysis of the N-acyl deriv. or redn. of the hydroxy benzaldehyde oxime. Pref. (I; X' = t-Bu X2 = CF3) is prepd. by hydrolysis of the N-chloroacetyl deriv.
FR7406084A 1974-02-22 1974-02-22 4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents Granted FR2261754A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7406084A FR2261754A1 (en) 1974-02-22 1974-02-22 4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7406084A FR2261754A1 (en) 1974-02-22 1974-02-22 4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents

Publications (2)

Publication Number Publication Date
FR2261754A1 true FR2261754A1 (en) 1975-09-19
FR2261754B1 FR2261754B1 (en) 1978-01-13

Family

ID=9135321

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7406084A Granted FR2261754A1 (en) 1974-02-22 1974-02-22 4,6-Disubstd-2-aminomethyl phenols - as antiinflammatory, diuretic and salidiuretic agents

Country Status (1)

Country Link
FR (1) FR2261754A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413358A1 (en) * 1977-12-29 1979-07-27 Ono Pharmaceutical Co NEW 2-AMINOMETHYLPHENOL DERIVATIVES, USEFUL IN PARTICULAR AS ANTI-INFLAMMATORY AGENTS, AND THEIR PREPARATION PROCESS
US4588844A (en) * 1983-02-08 1986-05-13 Bayer Aktiengesellschaft Process for preparing aromatic aldehydes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413358A1 (en) * 1977-12-29 1979-07-27 Ono Pharmaceutical Co NEW 2-AMINOMETHYLPHENOL DERIVATIVES, USEFUL IN PARTICULAR AS ANTI-INFLAMMATORY AGENTS, AND THEIR PREPARATION PROCESS
US4588844A (en) * 1983-02-08 1986-05-13 Bayer Aktiengesellschaft Process for preparing aromatic aldehydes

Also Published As

Publication number Publication date
FR2261754B1 (en) 1978-01-13

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Legal Events

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ST Notification of lapse